Efficacy of Cuminum Cyminum Herbal =Preparation in Inhibition of Plaque and Gingivitis.

Chronic Gingivitis Clinical Trial

Official title:

Efficacy of Cuminum Cyminum Herbal Preparation in Inhibition of Plaque and Gingivitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04767269
• Other study ID #: MaharishiMu2012
• Status: Completed
• Phase: Phase 2/Phase 3
• Start date: January 1, 2019
• Est. completion date: January 31, 2021

Study information

• Verified date: February 2021
• Source: Maharishi Markendeswar University (Deemed to be University)
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Present work was to investigate the possible efficacy of 0.2% cuminum cyminum herbal preparation as an antiplaque and antigingivitis agent when compared with chlorhexidine.

Description:

To evaluate and compare the efficacy of 0.2% cuminum cyminum herbal preparation against 0.2% chlorhexidine by various clinical parameters i.e. plaque index, gingival index and sulcus bleeding index.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 31, 2021
• Est. primary completion date: January 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 23 Years to 30 Years

Eligibility

Inclusion Criteria:

• volunteers with minimum 20 natural teeth without restoration.
• cooperative
• motivated and committed to participate in the trial period.

Exclusion Criteria:

• Antibiotic or anti-inflammatory therapy in previous month.
• Any known allergy/ hypersensitivity to any product used in trial.

Related Conditions & MeSH terms

• Chronic Gingivitis
• Gingivitis

Intervention

Drug:
• Cuminum Cyminum
Cuminum Cyminum mouthwash in chronic gingivitis patients
• herbal Mouthwash
herbal mouthwash in chronic gingivitis patients

Locations

Country	Name	City	State
India	Department of Periodontology, M.M. College of Dental Sciences and Research.	Ambala	Haryana

Sponsors (1)

Lead Sponsor	Collaborator
Maharishi Markendeswar University (Deemed to be University)

Country where clinical trial is conducted

India, 

References & Publications (3)

Bettaieb I, Bourgou S, Wannes WA, Hamrouni I, Limam F, Marzouk B. Essential oils, phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.). J Agric Food Chem. 2010 Oct 13;58(19):10410-8. doi: 10.1021/jf102248j. — View Citation

Salgado AD, Maia JL, Pereira SL, de Lemos TL, Mota OM. Antiplaque and antigingivitis effects of a gel containing Punica granatum Linn extract: a double-blind clinical study in humans. J Appl Oral Sci. 2006 Jun;14(3):162-6. — View Citation

Southern EN, McCombs GB, Tolle SL, Marinak K. The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. J Dent Hyg. 2006 Winter;80(1):12. Epub 2006 Jan 1. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PLAQUE INDEX	PLAQUE INDEX: Turesky-Gilmore-Glickman Modification of Quigley Hein 1962	changes from baseline to 8 days
Primary	Gingival Index	Gingival Index: Loe H ans Silness 1963	changes from baseline to 8 days
Primary	Bleeding on probing	Bleeding on probing: Muhlemann HR and Son 1971	changes from baseline to 8 days