Chronic Disease Clinical Trial
Official title:
A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases
Effectiveness of fasting or fasting-mimicking diet has been proved an effective approach to treat metabolic and autoimmune diseases in mice. However, clinical trials performing prolonged fasting with more than 7 days have not been reported. Investigators conduct an open label, phase I/II clinical trial to evaluate the safety and effectiveness of the 21-day fasting-like diet in the treatment of metabolic and autoimmune diseases.
Although fasting has been proved an effective approach to treat metabolic and autoimmune
diseases in mice, prolonged fasting is difficult to implement in human-beings for the safety
and feasibility reasons.
In this clinical trial, we will recruit metabolic and autoimmune diseases and then follow a
traditional Chinese 21-day fasting-like diet process with extremely low calorie intake (about
5% of normal diet) and prolonged fasting-like period. Blood, urine, stool samples will be
collected on day 0 (baseline), day 4, day 7, day 14, day 21 and day 51 after it started up.
Therefore we can examine the changes of disease-associated physical indexes and metabolic
biomarkers pre and post the 21-day fasting-like diet.
The purpose of the study is to ascertain the impact of the fasting-like diet during the 21
days. The investigators hypothesize that the 21-day fasting-like diet can reduce the
biomarkers associated with aging and age-related diseases and benefit for the treatment of
metabolic and autoimmune diseases.
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