Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05811091 |
| Other study ID # |
Chronic diarrhea |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 5, 2024 |
| Est. completion date |
May 5, 2024 |
Study information
| Verified date |
March 2023 |
| Source |
Assiut University |
| Contact |
Esraa Mansour Omar |
| Phone |
01140285103 |
| Email |
asramnswr82[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
To asses prevalence of pathological findings in patients with chronic diarrhea and normal
colonoscopy
Description:
diarrhea is defined as the of 3 or more loose or liquid stools per day, or more frequently
than is normal for the individual. 3. (World Health ion. Diarrhoeal disease .Available 2017)
Diarrhea can be separated into acute, persistent and chronic types based on duration. Acute
diarrhea lasts less than 14 days whereas persistent diarrhea is longer than 14 days, but no
longer than 28 days( Zilla GC, Israel EJ. et al ..2012) Chronic diarrhea than 28 days.
(Schiller LR, Parda DS, et al..2017) In addition to duration of symptoms, chronic diarrhea
also tends to occur without a clear onset whereas persistent diarrhea can be thought of as an
acute process that has persisted for a longer period.( zilla GC, Israel EJ. et al ..2012) it
can be secondary to such heterogeneous causes as drug side effects, structural abnormalities
of the small bowel and/or colon, the result of previous gastrointestinal surgery,
inflammatory or neo-plastic pancreato biliary disease, or as part of an intestinal functional
disorder, such as functional diarrhea, or irritable bowel syndrome (IBS) that is diarrhea
predominant (IBS-D)or post infectious (PI-IBS) ( Burgers K, Lindberg B, 2020) or Primary
eosinophilic colitis (PEC) is defined as an inflam-matory disease of unknown etiology that
mainly manifests as abdominal pain and diarrhea, segmental or diffuse infil-tration of
eosinophils in the mucosa of the colon,( Villanueva MS, Alimi Y.et al ..2015)( Impellizzeri
G, Marasco G ,et al ..2019) or Enteropathies( are diseases that affect small bowel (SB)
function and clinically manifest as chronic diarrhea).( Jansson-Knodell CL, Hujoel IA, et al
2017) as Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL) is a rare aggressive
disease that mainly affects the SuB mucosa. Its symptoms can be nonspecific, but often
presents chronic diarrhea (Ramírez-Quintero JD, Carvajal JJ,et al..2021) Evaluation of the
colonic mucosa is very helpful in detecting inflam-matory bowel disease, ischemic colitis,
microscopic colitis, neoplasis, and intraepithelial infections. The endoscopic appearance of
the colon is normal, or almost normal, in some of those diseases, and thus they can go by un
detected .Different studies have shown that systematic endoscopic biopsies of the colon
provide good diagnostic yield in patients with chronic non inflammatory diarrhea and normal
colonoscopy (López-Valenzuela LA, Murcio-Pérez E, et al..2019) chronic inflammatory disorder
of the large intestine that mainly affects the elderly. Microscopic colitis differs from
classical inflammatory bowel disease (IBD) in its almost normal-appearing colonic mucosa and
histological findings consistent with increased lymphocytic infiltrates with or without
collagen fiber expansion (Khalili et al., 2020). Microscopic colitis has two major subtypes,
lymphocytic colitis (LC) and collagenous colitis (CC) (Shor et al., 2019) chronic watery
diarrhea and often have no weight loss These forms of colitis also have an entirely of normal
endoscopic appearance (Macaigne et al., 2014). If colonoscopy is done in patients suspected
of having IBS-D, random colon biopsies should be done to rule out , structural abnormalities
of the small bowel and/or colon, the result of previous gastrointestinal surgery,
inflammatory or neo-plastic pancreato biliary disease, or as part of an intestinal functional
disorder, such as functional diarrhea, or irritable bowel syndrome (IBS) that is diarrhea
predominant (IBS-D)or post infectious (PI-IBS) ( Burgers K, Lindberg B, 2020) or Primary
eosinophilic colitis and microscopic colitis (Münch et al., 2020).
