Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Chronic Arsenic Poisoning Clinical Trial

Official title: Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Status Completed

Clinical Trial Summary

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. Similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.

Clinical Trial Description

Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment.

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Arsenic Poisoning
• Chronic Arsenic Poisoning
• Keratosis

• NCT number: NCT01748669
• Study type: Interventional
• Source: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
• Status: Completed
• Phase: Phase 2
• Start date: October 2011
• Completion date: July 2012