Clinical Trials Logo

Clinical Trial Summary

Cholesteatoma is a destructive and expanding pathologic condition consisting of keratin pearl arising from a squamous epithelium in the middle ear and/or mastoid process. Evolution consists in a destruction of the ossicles as well as their possible spread through the base of the skull into the brain. Surgical treatment is required to prevent infectious or functional complications. A recurrence after surgery occurs in approximately 10% of patients and rarely affects initial site. Surgical treatment is the only care option for recurrent cholesteatoma. Various locations such as surgical approach cavity, mastoid, hypotympanum are seen. Temporal bone CT is performed prior to surgery for added information on bone erosions especially of ossicules, tegmen tympani, facial nerve canal of internal ear. Due high anatomical resolution and complex anatomy, temporal bone CT is usually displayed with Magnetic Resonance Imaging (MRI) in operating room to help surgical guidance .

Imaging especially using MRI is the cornerstone for diagnosis in asymptomatic patients. Since 2006, non echo planar imaging (EPI) Diffusion weighted imaging (DWI) Magnetic resonance imaging (MRI) (sequences has shown high accuracy to depict recurrent cholesteatoma. If EPI sequences had a high rate of diffeomorphic atefacts whereas non EPI sequences using either HAlf-Fourier acquisition Single-shot Turbo spin-Echo (HASTE) or Fast-spin-echo demonstrates less magnetic susceptibility artifacts. Multimodality fusion between NonEPI-DWI-MRI and computerized tomography (CT) is a rational promising tool to rise the performance for cholesteatomas delineation. The performances of NonEPI-DWI-MRI in assessing lesion spread and volume are still unknown and needs further investigations. The aim of the study is to assess the DWI-MRI/CT fusion feasibility, reproducibility and the accuracy prior to surgery propectively compared to surgical findings.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02903550
Study type Observational
Source Assistance Publique Hopitaux De Marseille
Contact Arthur VAROQUAUX
Email arthur.varoquaux@ap-hm.fr
Status Recruiting
Phase N/A
Start date August 2015
Completion date March 2018

See also
  Status Clinical Trial Phase
Active, not recruiting NCT06268938 - Outcomes of Mastoid Obliteration Canal Wall Down Tympanomastoidectomy in Cholesteatoma Surgery N/A
Recruiting NCT05921643 - Short- and Medium-term Evaluation of Mastoid Filling Using Bioactive Glass"
Completed NCT06016335 - MRI-based Synthetic CT Images of the Head and Neck N/A
Active, not recruiting NCT03294421 - Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy N/A
Completed NCT01855425 - Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose N/A
Not yet recruiting NCT03305796 - Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging N/A
Not yet recruiting NCT06424704 - Chronic Suppurative Otitis Media Microbiology
Recruiting NCT03954288 - The Serum Sclerostin Levels in Cholesteatoma Patients
Completed NCT04959539 - Endoscopic Transcanal Tympanoplasty With Attico-antrostomy Versus Endoscopic-assisted Canal Wall up Mastoidectomy in Management of Localized Cholesteatoma: A Randomized Clinical Trial N/A
Active, not recruiting NCT00270660 - A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media Phase 3
Recruiting NCT03915392 - Diffusion Weighted MRI Accuracy in Cholesteatoma Localization
Completed NCT00682409 - Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in Children N/A
Completed NCT01638052 - Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery Phase 2
Completed NCT02019888 - Wide Frequency Band Test of Hearing in Veterans