The Serum Sclerostin Levels in Cholesteatoma Patients

Status Recruiting

Clinical Trial Summary

The aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. So far, there is no study showing the levels of sclerostin in cholesteatoma. The investigators hope that the results of our study will start new processes that can be used in the clinic.

Clinical Trial Description

Chronic otitis media (COM) is the perforation of the eardrum and mucosal inflammation of the space in the middle ear and the air cavities of the temporal bone over a period of three months. Although COM is defined as a multifactorial disease, its etiopathogenesis has not been fully elucidated. Cholesteatoma is a condition that disrupts the balance between bone formation and resorption in COM. The cholesteatoma is a destructive squamous epithelial lesion of temporal bone, it gradually expands and leads to serious complications by the destruction of near bone structures, ossicular chain and otic capsule. A growing debate examines the role of bone formation and destruction with osteoblasts, osteocytes and osteoclast cells in cholesteatoma formation. Sclerostin is a glycoprotein that plays a role in the regulation of bone metabolism secreted by osteocytes. Antibodies directed against sclerostin stimulate bone formation and represent a new therapeutic option for the treatment of increased bone resorption diseases, such as osteoporosis and generalized bone loss, inflammatory diseases with cartilage damage. The aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. So far, there is no study showing the levels of sclerostin in cholesteatoma. The investigators hope that the results of our study will start new processes that can be used in the clinic. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03954288
Study type	Observational [Patient Registry]
Source	Abant Izzet Baysal University
Contact	özgür m yis
Phone	05324940572
Email	dromyis@mynet.com
Status	Recruiting
Phase
Start date	March 29, 2019
Completion date	March 15, 2020

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT06268938` - Outcomes of Mastoid Obliteration Canal Wall Down Tympanomastoidectomy in Cholesteatoma Surgery	N/A
Recruiting	`NCT05921643` - Short- and Medium-term Evaluation of Mastoid Filling Using Bioactive Glass"
Completed	`NCT06016335` - MRI-based Synthetic CT Images of the Head and Neck	N/A
Active, not recruiting	`NCT03294421` - Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy	N/A
Completed	`NCT01855425` - Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose	N/A
Not yet recruiting	`NCT03305796` - Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging	N/A
Completed	`NCT04959539` - Endoscopic Transcanal Tympanoplasty With Attico-antrostomy Versus Endoscopic-assisted Canal Wall up Mastoidectomy in Management of Localized Cholesteatoma: A Randomized Clinical Trial	N/A
Active, not recruiting	`NCT00270660` - A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media	Phase 3
Recruiting	`NCT03915392` - Diffusion Weighted MRI Accuracy in Cholesteatoma Localization
Completed	`NCT00682409` - Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in Children	N/A
Completed	`NCT01638052` - Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery	Phase 2
Completed	`NCT02019888` - Wide Frequency Band Test of Hearing in Veterans
Recruiting	`NCT02903550` - Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas	N/A