Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children

Status Completed

Clinical Trial Summary

The study was designed to define the interaction of intravenous infusion of dexmedetomidine, an a2-adrenergic agonist, and sevoflurane in children having surgery by using the minimum alveolar concentration which can block adrenergic and cardiovascular responses to incision(MACbar) of sevoflurane as the measure of anesthetic potency.

Clinical Trial Description

The investigators observed the effects of different doses of dexmedetomidine on the minimum alveolar concentration of sevoflurane to blockade adrenergic response to surgical incision in 50% of children (MACBAR). And to explore the safety of use of dexmedetomidine in pediatric patients. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)

Related Conditions & MeSH terms

Children

Clinical Trial Details

NCT number	NCT02261675
Study type	Interventional
Source	First Affiliated Hospital, Sun Yat-Sen University
Contact
Status	Completed
Phase	N/A
Start date	January 2013
Completion date	April 2014

View Details

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