Children LTBI Clinical Trial
Official title:
A Multicentre, Cohort Study of Screening and Preventive Intervention for Latent Tuberculosis Infection in Children
The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy. However, national guidelines on latent tuberculosis infection testing and treatment have not yet been developed in children of China. Here, we present the results from the 3-year follow-up of a study that aimed to track the development of active disease in individuals with latent tuberculosis infection, identify priority populations for latent infection management, and explore the most suitable latent infection diagnostic approach.
1. Baseline analysis of a population-based, multicentre, prospective cohort study
1. A baseline survey of a population-based, multicentre, prospective cohort study were took
in children (≤18).
2. Eligible participants were identifi ed by door-to-door survey with a household sampling
design.
3. Participants were screened for active tuberculosis and history of tuberculosis then used
a tuberculin skin test and an interferon-γ release assay (QuantiFERON [QFT]) to test for
latent infection.
2. Incidence of active tuberculosis in individuals with latent tuberculosis infection in
children of China under different treatment regimens
1. Individuals who had tuberculosis infection at baseline (QFT-positivity or TST tuberculin
reaction size [induration] of ≥10 mm) were divided and treatment with different
therapeutic schedule.
2. Follow-up study were conducted to assess the proportion of latent TB infection converted
to active TB
;