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Childhood-onset Fluency Disorder clinical trials

View clinical trials related to Childhood-onset Fluency Disorder.

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NCT ID: NCT05641701 Not yet recruiting - Clinical trials for Childhood-Onset Fluency Disorder (Stuttering)

Stimulation of the Thalamus to Ameliorate Persistent Disfluency

SToPeD
Start date: November 1, 2023
Phase: N/A
Study type: Interventional

Persistent developmental stutter / childhood onset fluency disorder is a disabling condition leading to significant communication and psychological disability. Established treatment consists of intensive speech therapy, and whilst initially effective, has a waning long-term benefit. Our research team aims to provide evidence of stutter management by addressing the primary neurological issue in this disorder using Deep Brain Stimulation. The investigators propose to perform bilateral DBS on 3 participants with stutter refractory to intensive speech therapy, to determine a response in their stutter. The assessments will be double-blinded. The investigators will use the outcome of this small pilot study to determine the feasibility and details of a larger randomized controlled trial.

NCT ID: NCT05583955 Completed - Clinical trials for Childhood-Onset Fluency Disorder

A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)

Start date: July 25, 2022
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the effectiveness of NOE-105 on speech fluency without the known antipsychotic-induced side effects of commonly used treatments for childhood onset fluency disorder (COFD).

NCT ID: NCT04492956 Completed - Clinical trials for Childhood-Onset Fluency Disorder (Stuttering)

Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)

Start date: October 2, 2020
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 exploratory study in adult subjects with childhood onset fluency disorder.

NCT ID: NCT02909088 Recruiting - Speech Disorders Clinical Trials

Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).

Start date: September 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the efficacy and tolerability of ecopipam in reducing stuttering symptoms. It is hypothesized that ecopipam effectively reduces stuttering symptoms as measured on the SSI-IV total score, the CGI, SSS and OASES.