Maternal Grandmothers in the Born in Guangzhou Cohort Study

Childhood Obesity Clinical Trial

— MGBIG  

Official title:

Maternal Grandmothers in the Born in Guangzhou Cohort Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03633162
• Other study ID #: 2018041801
• Secondary ID: 8167318120150803
• Status: Recruiting
• Start date: May 21, 2018
• Est. completion date: December 31, 2038

Study information

• Verified date: September 2023
• Source: Guangzhou Women and Children's Medical Center
• Contact: Xiu Qiu, PhD
• Phone: 0086 20 38367160
• Email: qxiu0161[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Description:

It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 5000
• Est. completion date: December 31, 2038
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 36 Years to 100 Years

Eligibility

Inclusion Criteria:

1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center

2. Baseline information of maternal grandmother's daughter during pregnancy available

Exclusion Criteria:

1. Significant cardiovascular abnormalities

2. Intelligent obstacle, intellectual disabilities or gawkish condition

Related Conditions & MeSH terms

• Childhood Obesity
• Hereditary Transmission
• Host and Microbiome
• Immune Development
• Neurodevelopment
• Pediatric Obesity

Locations

Country	Name	City	State
China	Guangzhou Women and Children's Medical Center	Guangzhou	Guangdong

Sponsors (3)

Lead Sponsor	Collaborator
Guangzhou Women and Children's Medical Center	Children's Hospital Medical Center, Cincinnati, University of Birmingham

Country where clinical trial is conducted

China, 

References & Publications (2)

Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23. — View Citation

Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring	Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers	From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth
Secondary	Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life	Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc.	At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren
Secondary	The prevalence of eczema of grandchildren	Assessed by self-reported time of onset and electronic medical record	At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Secondary	The incidence of asthma of grandchildren	Assessed by self-reported time of onset and electronic medical record	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Secondary	The prevalence of Allergic rhinitis of grandchildren	Assessed by self-reported time of onset and electronic medical record	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Secondary	The prevalence of Food allergy of children and grandchildren	Assessed by self-reported time of onset and electronic medical record	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Secondary	Changes of body composition of grandchildren	Body composition is assessed using Dual Energy X-Ray Absorptiometry	At age of 3 years,6 years, 12years and 18years
Secondary	Changes of bone density of grandchildren	Bone density is assessed using Dual Energy X-Ray Absorptiometry	At age of 3 years,6 years, 12years and 18years