Child Clinical Trial
Official title:
Endoscopic Variceal Ligation as Primary Prophylaxis for Upper Gastrointestinal Bleeding in Children
This is an ambispective single-center cohort study of pediatric patients with portal hypertension and esophageal varices. The study was designed to evaluate the efficacy and safety of primary prophylaxis with endoscopic variceal ligation to prevent upper gastrointestinal bleeding compared to non-selected beta-blockers prophylaxis.
Endoscopic Variceal Ligation group; Inclusion criteria From January 2014 to April 2017, a
study group was created, including all paediatric patients with a known chronic liver disease
with suspicion of portal hypertension and grade 2 or 3 OV or red spots, regardless of the
grade of the OV diagnosed by endoscopy.
Propanolol group Patients in the Endoscopic Variceal Ligation study group were compared with
an historical cohort of 30 consecutive patients with portal hypertension and grade 2 or 3
esophageal varices or red spots, regardless of the grade of the esophageal varices in the
upper endoscopy, who received propranolol as primary prophylaxis from January 2009 to
December 2013.
Ligation sessions were performed every 6 weeks until varices eradication. When eradication
was achieved, upper endoscopy was performed at 2 and 6 months to assess the efficacy of the
treatment. If no varices were observed, upper endoscopies were performed once a year
thereafter.
Eradication was defined as disappearance of all varices or reduction to grade 1 small varices
without reddish spots and no gastric varices.
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