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Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso — ARMCA  

Child Development Clinical Trial

Official title:
Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso

Clinical Trial Summary

The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome. This study is designed to estimate the effect of antibiotic consumption on microbiome in a rural region of rural Burkina Faso. Changes in the intestinal and nasopharyngeal microbiome and resistome following a short course of antibiotics will be measured.

Clinical Trial Description

This study is designed to better understand the effect of a short course of antibiotics on changes in intestinal and nasopharyngeal microbiome on treated children and untreated household contacts. The investigators hypothesize that a short course of antibiotics will lead to decreased bacterial diversity shortly after completion of the antibiotic course, and higher probability of identification of bacterial resistance genes in rectal and nasopharyngeal samples. The investigators hypothesize that a 5-day course of antibiotics (azithromycin, amoxicillin, or co-trimoxazole) will lead to significantly decreased intestinal and nasopharyngeal bacterial diversity among children aged 6-59 months. Specific Aim 1. Determine the effect of treatment with antibiotics on microbiome diversity in children aged 6-59 months following a 5-day course of antibiotics. Specific Aim 1A. Determine the direct effect of a 5-day course of azithromycin, amoxicillin, or co-trimoxazole on intestinal and nasopharyngeal bacterial diversity in children aged 6-59 months compared to no treatment. Specific Aim 1B. Determine the indirect effect of antibiotic treatment of children in a household on intestinal and nasopharyngeal bacterial diversity in an untreated child aged 6-59 months. Specific Aim 1C. Assess the association between intestinal bacterial diversity and anthropometry in a population-based sample of children. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03187834
Study type Interventional
Source University of California, San Francisco
Contact
Status Completed
Phase Phase 4
Start date July 4, 2017
Completion date September 1, 2019
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