Chest Pain Clinical Trial
— PERFECTOfficial title:
ProspEctive Randomized First Evaluation in Chest Pain Trial
The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.
Status | Completed |
Enrollment | 411 |
Est. completion date | December 2015 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 45 Years and older |
Eligibility |
Inclusion Criteria: - Patients with chest pain or SOB admitted for rule out acute coronary syndrome - Age =45 years - EKG non-diagnostic for acute coronary syndrome - At least 1 set of negative troponin I Exclusion Criteria: - Patient with ST elevation myocardial infarction. - Patients with non-ST elevation myocardial infarction. - Patients with known CAD. - Patients with serum creatinine > 1.5. - Atrial fibrillation or marked irregular heart rhythm. - Patients in whom heart rate cannot be controlled. - Patient with allergies to iodinated contrast agents. - Pregnant women - Patients unable to give informed consent |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
United States | St. Luke's and Roosevelt Hospitals | New York | New York |
Lead Sponsor | Collaborator |
---|---|
St. Luke's-Roosevelt Hospital Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time to discharge | Initial hospitalization | No | |
Primary | Change in medical regimen | Initial hospitalization | No | |
Primary | Downstream cardiovascular testing and hospitalization | 2 years | No | |
Secondary | All-cause mortality | This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain. | 7 days, 30 days, 6, 12, and 24 months. | Yes |
Secondary | Cardiovascular mortality | This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain. | 7 days, 30 days, 6, 12, and 24 months. | Yes |
Secondary | Non-fatal myocardial infarction | This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain. | 7 days, 30 days, 6, 12, and 24 months. | Yes |
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