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Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management — CHEMODEX  

Chemotherapy-induced Peripheral Neuropathy Clinical Trial

Official title:
Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management

Clinical Trial Summary

The aim of this study is to assess if dextromethorphan administered during 4 weeks induces a decrease of pain intensity in breast cancer patients suffering from chemotherapy-induced peripheral neuropathy compared to placebo group.

Clinical Trial Description

This is a randomized, placebo-controlled, double-blind, parallel-group clinical trial comparing dextromethorphan and placebo for the treatment of chemotherapy-induced peripheral neuropathy, assessed with a (0-10) numerical scale. Cognition, anxiety, depression, sleep and quality of life are also assessed. The influence of CYP2D6, CYP3A4 and MDR1 polymorphism on the dextromethorphan analgesic efficacy will be measured. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02271893
Study type Interventional
Source University Hospital, Clermont-Ferrand
Contact
Status Terminated
Phase Phase 2
Start date November 25, 2014
Completion date April 21, 2022
View Details
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