Cesarean Section Clinical Trial
Official title:
Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension in Preoperatively Anxious Parturients Undergoing Urgent Category-1 Cesarean Section: A Historical Cohort Study
Background: This study was designed to investigate the effect of sedation on the occurrence
of maternal hypotension in preoperatively anxious parturients undergoing urgent category-1
Cesarean section (C/S) under spinal anesthesia.
Methods: After institutional ethics committee approval, prospectively collected data of 1824
parturients undergoing C/S were reviewed. Parturients with high preoperative anxiety scores
(visual analogue scale for anxiety (VAS-A)≥70) undergoing C/S under spinal anesthesia with
thiopental (Group S=49) and without any other type of sedation (Group NS=53) were included
in the analysis. Hemodynamic parameters were documented and maximum systolic arterial
pressure (SAP) reductions from the baseline after spinal anesthesia were calculated.
Incidences of hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia
(HR<55 beats/min), and related-ephedrine and -atropine requirements were noted. Our primary
endpoint was to compare the maximum SAP reductions from the baseline values in Groups S and
NS. Secondary endpoints were incidences of hypotension and bradycardia, required ephedrine
and atropine doses, newborn Apgar scores at 1st and 5th min.
Background: This study was designed to investigate the effect of thiopental sodium sedation
on the occurrence of maternal hypotension in preoperatively anxious parturients undergoing
urgent category-1 Cesarean section (C/S) under spinal anesthesia.
Methods: After institutional ethics committee approval, prospectively collected data of 1824
parturients undergoing C/S at Van Training and Research Hospital between August 2014 and
February 2015 were reviewed. Parturients with high preoperative anxiety scores (visual
analogue scale for anxiety (VAS-A)≥70) undergoing C/S under spinal anesthesia with
thiopental (Group S=49) and without any other type of sedation (Group NS=53) were included
in the analysis. All parturients received SA with hyperbaric bupivacaine 0.5% 2.5 mL.
Hemodynamic parameters were documented and maximum systolic arterial pressure (SAP)
reductions from the baseline after spinal anesthesia were calculated. Incidences of
hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia (HR<55 beats/min),
and related-ephedrine and -atropine requirements were noted. All data were obtained from the
surgical database and patient charts. Primary endpoint of our study was to compare the
maximum SAP reductions from the baseline values in Groups S and NS. Secondary endpoints were
incidences of hypotension and bradycardia, required ephedrine and atropine doses, newborn
Apgar scores at 1st and 5th min.
;
Observational Model: Cohort, Time Perspective: Retrospective
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