Cesarean Section Clinical Trial
Official title:
Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension in Preoperatively Anxious Parturients Undergoing Urgent Category-1 Cesarean Section: A Historical Cohort Study
Background: This study was designed to investigate the effect of sedation on the occurrence
of maternal hypotension in preoperatively anxious parturients undergoing urgent category-1
Cesarean section (C/S) under spinal anesthesia.
Methods: After institutional ethics committee approval, prospectively collected data of 1824
parturients undergoing C/S were reviewed. Parturients with high preoperative anxiety scores
(visual analogue scale for anxiety (VAS-A)≥70) undergoing C/S under spinal anesthesia with
thiopental (Group S=49) and without any other type of sedation (Group NS=53) were included
in the analysis. Hemodynamic parameters were documented and maximum systolic arterial
pressure (SAP) reductions from the baseline after spinal anesthesia were calculated.
Incidences of hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia
(HR<55 beats/min), and related-ephedrine and -atropine requirements were noted. Our primary
endpoint was to compare the maximum SAP reductions from the baseline values in Groups S and
NS. Secondary endpoints were incidences of hypotension and bradycardia, required ephedrine
and atropine doses, newborn Apgar scores at 1st and 5th min.
Background: This study was designed to investigate the effect of thiopental sodium sedation
on the occurrence of maternal hypotension in preoperatively anxious parturients undergoing
urgent category-1 Cesarean section (C/S) under spinal anesthesia.
Methods: After institutional ethics committee approval, prospectively collected data of 1824
parturients undergoing C/S at Van Training and Research Hospital between August 2014 and
February 2015 were reviewed. Parturients with high preoperative anxiety scores (visual
analogue scale for anxiety (VAS-A)≥70) undergoing C/S under spinal anesthesia with
thiopental (Group S=49) and without any other type of sedation (Group NS=53) were included
in the analysis. All parturients received SA with hyperbaric bupivacaine 0.5% 2.5 mL.
Hemodynamic parameters were documented and maximum systolic arterial pressure (SAP)
reductions from the baseline after spinal anesthesia were calculated. Incidences of
hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia (HR<55 beats/min),
and related-ephedrine and -atropine requirements were noted. All data were obtained from the
surgical database and patient charts. Primary endpoint of our study was to compare the
maximum SAP reductions from the baseline values in Groups S and NS. Secondary endpoints were
incidences of hypotension and bradycardia, required ephedrine and atropine doses, newborn
Apgar scores at 1st and 5th min.
;
Observational Model: Cohort, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03772886 -
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball
|
N/A | |
| Completed |
NCT03631329 -
Predictability of Preoperative Carotid Artery Corrected Flow Time for Hypotension After Spinal Anesthesia in Patients Undergoing Cesarean Section
|
||
| Completed |
NCT03244540 -
Regional Analgesia After Cesarean Section
|
Phase 4 | |
| Active, not recruiting |
NCT03760718 -
Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery
|
Early Phase 1 | |
| Active, not recruiting |
NCT04965779 -
The Effect of Abdominal Binder Use on Postpartum Pain, Bleeding, and Breastfeeding Success in Cesarean Delivery Women
|
N/A | |
| Terminated |
NCT01687972 -
INSORB Versus Subcuticular Sutures at Cesarean Section
|
Phase 1 | |
| Withdrawn |
NCT01211431 -
Post-cesarean Pain Control Via Continuous Infusion of Ropivacain et Diclogenac Into the Wound Versus Intathecal Morphine
|
Phase 4 | |
| Completed |
NCT00991627 -
Different Approaches to Maternal Hypotension During Cesarean Section
|
Phase 4 | |
| Completed |
NCT00987701 -
Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors
|
N/A | |
| Completed |
NCT01049477 -
The Effects of Music Therapy on Women's Anxiety Before and During Cesarean Delivery
|
N/A | |
| Terminated |
NCT00524511 -
Comparison Study of Wound Closure at Time of Cesarean Delivery: Dermabond Glue Versus Surgical Staples
|
N/A | |
| Completed |
NCT00375986 -
A Comparison of Manual vs. Spontaneous Removal of the Placenta at Cesarean Section
|
N/A | |
| Terminated |
NCT00386477 -
Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
|
N/A | |
| Completed |
NCT00517140 -
Vaginal Birth After Caesarean Section - Effect on Maternal Psychosocial Function
|
N/A | |
| Terminated |
NCT05051150 -
Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Caesarean Section
|
Phase 4 | |
| Terminated |
NCT03695172 -
Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section
|
Phase 4 | |
| Recruiting |
NCT06247852 -
Persistent Pain After Cesarean Delivery - A Danish Multicenter Cohort Study
|
||
| Recruiting |
NCT06012747 -
Pain After Cesarean Section - A Danish Multicenter Cohort Study.
|
||
| Not yet recruiting |
NCT05187520 -
Naldebain for Control of Post-Cesarean Section Pain
|
Phase 2 | |
| Not yet recruiting |
NCT04999670 -
Fascial Closure and Post-caesarean Pain
|
N/A |