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Clinical Trial Summary

This research is being done to determine how effective dostarlimab in combination with cobolimab is in metastatic or recurrent cervical cancer.


Clinical Trial Description

This is a non-randomized, open-label, two-arm phase 2 trial of dostarlimab and cobolimab for participants with metastatic or recurrent cervical cancer who have or have not been treated with immunotherapy previously. The names of the study drugs involved in this study are: - Cobolimab (a type of monoclonal antibody) - Dostarllimab (a type of monoclonal antibody) The U.S. Food and Drug Administration (FDA) has not approved cobolimab as a treatment for cervical cancer. The FDA has not approved dostarlimab for cervical cancer but it has been approved for other uses. The study procedures including, screening for eligibility, treatment visits, blood tests, x-rays, Computerized Tomograph (CT) scans, Magnetic Resonance Imaging (MRI) scans, or Positron Emission Tomograph (PET) scans. Participants will be followed for up to 7 years. It is expected that about 66 people will take part in this research study. GlaxoSmithKline is funding this research study by providing funding and the study drugs. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06238635
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact Meghan Shea, MD
Phone 617-667-2100
Email Mshea4@bidmc.harvard.edu
Status Recruiting
Phase Phase 2
Start date March 11, 2024
Completion date July 15, 2027

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