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Clinical Trial Summary

Human papillomavirus infections 16 (HPV16) is known to be a high-risk factor to induce cervical cancers. To date, HPV16-related cervical cancer is still a major concern in developing countries where vaccination is not prevalent. Concurrent therapies for cervical cancers have limited response rate and high chance of relapse. However, HPV16-induced cancers provided an ideal target for T cell-based immunotherapy due to the non-self origins. Engineered T cells bearing a TCR (TCR-T) that can specifically recognize the presented HPV antigen become a viable approach to treat this type of cancer. Though engineered T therapies have been well-recognized in hematological cancers, solid cancer treatment has been a major hurdle due to the immune-suppressive tumor microenvironment. One key mechanism of tumor-elicited suppression is the PDL1-PD1 interaction which induces T cell exhaustion. Therefore, TCR-T cells armed with a PD1 antagonist could further enhance the efficacy of TCR-T in solid cancers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03578406
Study type Interventional
Source Xinqiao Hospital of Chongqing
Contact Qingzhu Jia
Phone +8615223334184
Email jiaqingzhu0801@outlook.com
Status Recruiting
Phase Phase 1
Start date September 1, 2018
Completion date August 30, 2021

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