Cerebrovascular Disorders Clinical Trial
Official title:
Safety and Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosome on Disability of Patients With Acute Ischemic Stroke: a Randomized, Single-blind, Placebo-controlled, Phase 1, 2 Trial
Administration of cell-free exosomes derived from mesenchymal stem cell (MSCs) can be sufficient to exert therapeutic effects of intact MSCs after brain injury. In this study we aim to assay the administration of MSC derived exosome on improvement of disability of patients with acute ischemic stroke
Exosomes derived from multipotent mesenchymal stromal cells (MSCs) promote neurovascular remodeling and functional recovery after stroke. Animal study has shown that Exosome treatment markedly increased the number of newly formed doublecortin (a marker of neuroblasts) and von Willebrand factor (a marker of endothelial cells) cells. Based on previous literature, intravenous administration of MSC-generated exosomes post stroke improves functional recovery and enhances neurite remodeling, neurogenesis, and angiogenesis and represents a novel treatment for stroke. Also some studies have presented which miR-124-Loaded Exosomes ameliorate the brain Injury by promoting neurogenesis. So in present study we aim to assess improving patients with acute ischemic stroke who received MSC derived exosome ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03239847 -
Cost Effectiveness of the EndoPhys Pressure Sensing Access System vs. Radial A-line for Intra-operative Blood Pressure Monitoring
|
N/A | |
| Recruiting |
NCT03544801 -
Renji Cerebral Small Vessel Disease Corhort Study
|
||
| Recruiting |
NCT06010823 -
Safety and Efficacy Evaluation of the Robotic Enhanced Error Training of Upper Limb Function in Post-stroke and Post TBI Participants
|
N/A | |
| Withdrawn |
NCT04991038 -
Clinical Investigation to Compare Safety and Efficacy of DAISE and Stent Retrievers for Thrombectomy In Acute Ischemic Stroke Patients
|
N/A | |
| Recruiting |
NCT02472028 -
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
|
Phase 4 | |
| Completed |
NCT01915368 -
Determining Optimal Post-Stroke Exercise (DOSE)
|
N/A | |
| Active, not recruiting |
NCT01555411 -
Akershus Cardiac Examination (ACE) 1950 Study
|
||
| Completed |
NCT01304576 -
Orientation Agnosia: Clinical and Anatomical Study
|
N/A | |
| Completed |
NCT00049920 -
The ARIC MRI Study
|
N/A | |
| Completed |
NCT00049894 -
Predictors of Recurrent Stroke in the PROGRESS Study
|
N/A | |
| Completed |
NCT00059293 -
Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUG
|
||
| Completed |
NCT00005562 -
Coronary Artery Calcium, Exercise Tests, and CHD Outcome
|
N/A | |
| Completed |
NCT00005395 -
Honolulu Heart Program-Study of Stroke and Dementia
|
N/A | |
| Completed |
NCT00000479 -
Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer
|
Phase 3 | |
| Completed |
NCT00005140 -
Epidemiology of Cardiovascular and Non-Cardiovascular Risk In Chicago
|
N/A | |
| Enrolling by invitation |
NCT00005485 -
The Jackson Heart Study of Cardiovascular Disease Among African Americans
|
||
| Recruiting |
NCT06275113 -
BRING-UP Prevention
|
||
| Completed |
NCT02702635 -
Measuring Blood Flow Characteristics Using Dynamic Contrast Enhanced Magnetic Resonance Imaging
|
N/A | |
| Recruiting |
NCT04336852 -
Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function
|
N/A | |
| Not yet recruiting |
NCT05892510 -
Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke
|
Phase 2/Phase 3 |