Clinical Trials Logo
  1. Home
  2. Cerebrovascular Disease
  3. NCT03774017

Research on Hybrid Operation Technique in the Treatment of Complex Brain Arteriovenous Malformations — HOTAVM  

Cerebrovascular Disease Clinical Trial

Official title:
Study on Benefits and Risks of Hybrid Operation in the Treatment of Complex Brain Arteriovenous Malformations

Clinical Trial Summary

Complex brain arteriovenous malformations (bAVMs) in ≥3 Spetzler-Martin grades have long been challenges among cerebrovascular diseases. None of the traditional methods, such as microsurgical operation, endovascular intervention, or stereotactic radiotherapy, can completely eliminate complex bAVMs without a risk of neural function deterioration. The multistaged hybrid operation solved part of the challenge but remained risky in the installment procedures and intervals. The one-staged hybrid operation was applied in the surgical treatment of cerebrovascular diseases and proved to be a potentially safe and effective method for curing complex bAVMs. However, lacking the support of high-level evidence, its advantages remain unclear. This study was proposed to validate the benefits and risks of one-staged hybrid operation in the treatment of complex bAVMs, as well as its indications, key technologies, and workflows.

Clinical Trial Description

The study is being conducted from Jan 2016 to Dec 2020 with 20 cooperation units. It consists of 2 sets. The registry set is designed as a prospective real-world registry. The trial set is designed as a prospective pragmatic clinical trial, specifically for the patients with perforating arterial feeders. The two sets share a common grouping: the traditional operation group and the one-staged hybrid operation group. The assignment is based on the clinical condition in the registry set and is randomized in the trial set. End points will be evaluated at scheduled time points. The safety and efficiency of one-staged hybrid operation in treating complex bAVMs will be validated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03774017
Study type Interventional
Source Ministry of Science and Technology of the People´s Republic of China
Contact Shuo Wang, MD
Phone 861059976510
Email captain9858@vip.sina.com
Status Recruiting
Phase N/A
Start date January 1, 2016
Completion date December 31, 2020
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02248311 - "Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population N/A
Completed NCT01604486 - Natural Ischaemic Preconditioning Before First Myocardial Infarction N/A
Active, not recruiting NCT00627029 - Evaluation of Programs of Coordinated Care and Disease Management N/A
Recruiting NCT04336852 - Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function N/A
Not yet recruiting NCT05925699 - National Database of the Virtual Institute of Cerebrovascular Diseases
Recruiting NCT04443439 - Assess the Risk of Cerebrovascular Disease
Recruiting NCT04525144 - EGb 761 in the Syndrome of MCI With Concomitant CVD Phase 2
Completed NCT02553655 - Remote Ischemic Limb Preconditioning In Healthy Volunteers N/A
Recruiting NCT00385385 - RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease Phase 2
Recruiting NCT05247931 - Why Does Aspirin Fail in Secondary Cerebrovascular Prevention? A Multicenter Prospective Case - Control Study
Completed NCT02665585 - Plaque Prolapse Prevention Carotid Artery Stenting (3PCAS) N/A
Recruiting NCT05834673 - VICTORION-ASCERTAIN: Implementation Study (v-ASCERTAIN) Phase 4
Recruiting NCT06115213 - The North Kynouria Project N/A
Recruiting NCT02730065 - Aerobic Dance Training in Small Vessel Disease N/A
Terminated NCT02440646 - Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
Completed NCT01924312 - Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease N/A
Completed NCT00333164 - Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis Phase 3
Not yet recruiting NCT06241482 - Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care N/A
Enrolling by invitation NCT02694094 - Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Not yet recruiting NCT04696120 - Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure: APIXBRAIN-HF Trial Phase 2