Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident

Cerebrovascular Accident Clinical Trial

— MEMOIRE ET EMO  

Official title:

Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02887105
• Other study ID #: PSS2012/MEMOIRE-DUCROCQ/MS
• Status: Completed
• Phase: N/A
• First received: August 24, 2016
• Last updated: September 7, 2016
• Start date: December 2012
• Est. completion date: April 2014

Study information

• Verified date: August 2016
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Commission nationale de l'informatique et des libertésFrance: Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé
• Study type: Observational

Clinical Trial Summary

The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed.

The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.

Description:

Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 76
• Est. completion date: April 2014
• Est. primary completion date: April 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin

• Right-handed

• Possible cooperation: understanding of French instructions

• Normal or corrected vision

• Normal or corrected hearing

• Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient

• Possible follow up of patient

Exclusion Criteria:

• Hearing problems

• Vision problems

• Right hemiplegia or acute monoparesis of right upper limb

• Hemispatial neglect

• Apraxia

• Psychiatric or neurological history possibly interfering with neuropsychological evaluation

• Important defect of working memory or executive functions

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Cerebrovascular Accident
• Stroke

Intervention

Other:
• Standard neuropsychological assessment

• Brain MRI

Locations

Country	Name	City	State
France	Service de Neurologie - Hôpital Bon Secours - CHR de Metz-Thionville	Metz
France	Service de Neurologie - Hôpital Central - CHU de Nancy	Nancy

Sponsors (1)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	State of anxiety evaluated with STAI-YA scale		up to 1 month (from CVA)	No
Primary	State of anxiety evaluated with STAI-YA scale		6 months (from CVA)	No
Primary	Anxiety proneness evaluated with STAI-YB scale		up to 1 month (from CVA)	No
Primary	Anxiety proneness evaluated with STAI-YB scale		6 months (from CVA)	No
Primary	Apprehension anxiety evaluated with Penn State Worry Questionnaire		up to 1 month (from CVA)	No
Primary	Apprehension anxiety evaluated with Penn State Worry Questionnaire		6 months (from CVA)	No
Primary	Evaluation of working memory updating with N-back verbal and visuospatial task		up to 1 month (from CVA)	No
Primary	Evaluation of working memory updating with N-back verbal and visuospatial task		6 months (from CVA)	No
Primary	Evaluation of working memory inhibition with Stimulus-response compatibility task		up to 1 month (from CVA)	No
Primary	Evaluation of working memory inhibition with Stimulus-response compatibility task		6 months (from CVA)	No
Primary	Evaluation of working memory flexibility with Switching task		up to 1 month (from CVA)	No
Primary	Evaluation of working memory flexibility with Switching task		6 months (from CVA)	No
Primary	Evaluation of verbal working memory with Wechsler memory scale		up to 1 month (from CVA)	No
Primary	Evaluation of verbal working memory with Wechsler memory scale		6 months (from CVA)	No
Primary	Evaluation of visuospatial working memory with Wechsler memory scale		up to 1 month (from CVA)	No
Primary	Evaluation of visuospatial working memory with Wechsler memory scale		6 months (from CVA)	No
Primary	Evaluation of visual episodic memory with Rey and Taylor figure test		6 months (from CVA)	No
Primary	Evaluation of verbal episodic memory with RL/RI 16 item test		6 months (from CVA)	No
Secondary	Hemispheric lateralization of lesions detected with MRI		up to 1 month from CVA	No
Secondary	Depression state evaluated with Back depression inventory		up to 1 month (from CVA)	No
Secondary	Depression state evaluated with Back depression inventory		6 months (from CVA)	No
Secondary	Quality of life evaluated with SF-36 test		after 6 months from CVA	No