Cerebral Palsy Clinical Trial
Official title:
Analgesia and Physiotherapy in Children With Cerebral Palsy (ANTALKINECP): Double Blind Cross-over Placebo Controlled Study of Ibuprofen in Children With Cerebral Palsy Undergoing Physiotherapy
SPARCLE 1 and 2 studies followed a cohort of 818 children with cerebral palsy (CP) between 8
and 12 (SPARCLE 1) and 13 and 18 years old (SPARCLE 2) interviewed at home. The prevalence of
pain in these populations was respectively 60 and 69% while it is about 35% in typically
developed children of the same age.
The main location of the pain for 60% of children with CP was the lower limbs, caused by
musculoskeletal pain and movement (for those who can) and therapeutic procedures. In SPARCLE
2, 50% of the children complained about pain during physical therapy.
If the pain is part of the management of physiotherapy, a recent review showed that for a
condition such as chronic back pain, the level of evidence of the effectiveness of
physiotherapy techniques in reducing pain is low. The effectiveness of these techniques would
include higher efficacy on anxiety than pain itself.
Despite significant involvement of physiotherapists in the management of pain, the focus on
pain should increase, in particular taking into account the procedural/induced pain (caused
by treatment).
In addition to drugs, physical methods (analgesic therapy) or psychotherapy are used to
reduce the pain of children during medical procedures. For the latter most of them require
the presence of two individuals to provide the therapy. This is unsuited for out-patient care
provided to the majority of children with CP.
Non steroid anti-inflammatory drug (NSAIDs), are first recommended, alone or in combination
with the treatment of several indications in child pain (migraine, postoperative pain, etc.).
Ibuprofen is commonly used in children during painful procedures and represented the 4th
molecule among prescribed per os analgesic drugs in 2008 in the United States.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05317234 -
Genetic Predisposition in Cerebral Palsy
|
N/A | |
| Recruiting |
NCT05576948 -
Natural History of Cerebral Palsy Prospective Study
|
||
| Completed |
NCT04119063 -
Evaluating Wearable Robotic Assistance on Gait
|
Early Phase 1 | |
| Completed |
NCT03264339 -
The Small Step Program - Early Intervention for Children With High Risk of Developing Cerebral Palsy
|
N/A | |
| Completed |
NCT05551364 -
Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
|
N/A | |
| Completed |
NCT03902886 -
Independent Walking Onset of Children With Cerebral Palsy
|
||
| Recruiting |
NCT05571033 -
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
|
N/A | |
| Not yet recruiting |
NCT04081675 -
Compliance in Children With Cerebral Palsy Supplied With AFOs
|
||
| Completed |
NCT02167022 -
Intense Physiotherapies to Improve Function in Young Children With Cerebral Palsy
|
N/A | |
| Completed |
NCT04012125 -
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
|
N/A | |
| Enrolling by invitation |
NCT05619211 -
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
|
Phase 1 | |
| Completed |
NCT04489498 -
Comparison of Somatometric Characteristics Between Cerebral Palsy and Normal Children, Cross-sectional, Multi Center Study
|
||
| Completed |
NCT03677193 -
Biofeedback-enhanced Interactive Computer-play for Youth With Cerebral Palsy
|
N/A | |
| Completed |
NCT04093180 -
Intensive Neurorehabilitation for Cerebral Palsy
|
N/A | |
| Completed |
NCT02909127 -
The Pediatric Eating Assessment Tool
|
||
| Not yet recruiting |
NCT06377982 -
Human Umbilical Cord Blood Infusion in Patients With Cerebral Palsy
|
Phase 1 | |
| Not yet recruiting |
NCT06007885 -
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
|
N/A | |
| Not yet recruiting |
NCT03183427 -
Corpus Callosum Size in Patients With Pineal Cyst
|
N/A | |
| Active, not recruiting |
NCT03078621 -
Bone Marrow-Derived Stem Cell Transplantation for the Treatment of Cerebral Palsy
|
Phase 1/Phase 2 | |
| Completed |
NCT02849938 -
Evaluating the Value of Telehealth for Care of Children With Medical Complexity
|
N/A |