Cerebral Infarct Clinical Trial
Official title:
Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia
Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for
a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and
thrombectomy). Thrombolysis failure by the administration of rt-PA is frequent, in particular
in proximal occlusion. Experimental studies suggest that neutrophils could play an important
role in the thrombus development via the organization of a network (NET) within the thrombus.
Targeting this network of NET could, in addition to the fibrinolysis, increase the rate of
recanalisation and thus improve the neurological prognostic after a cerebral infarct.
The aim of the research is to Study of the biochemical and histological composition of the
stemming thrombi of cerebral thrombectomies with in vitro analysis of the sensibility in the
thrombolysis induced by rt-PA +/- Desoxyribonuclease I (DNase I).
n/a
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