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Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment

Central Nervous System Infections Clinical Trial

Official title:
Evaluation of Meropenem Penetration Across Blood-Brain Barrier in Patients With Central Nervous System Infection After Neurosurgery and Optimization of Meropenem Treatment

Clinical Trial Summary

A prospective, open-label study investigated the pharmacokinetic profile of meropenem in patients with post-neurosurgical central nervous system (CNS) infection, especially its BBB penetration into cerebrospinal fluid (CSF).

Clinical Trial Description

Meropenem is important for management of post-neurosurgical meningitis, but the data about its penetration across blood-brain barrier (BBB) are inadequate. This prospective, open-label study investigated the pharmacokinetic profile of meropenem in patients with post-neurosurgical central nervous system (CNS) infection, especially its BBB penetration into cerebrospinal fluid (CSF). A total of 82 patients with post-neurosurgical CNS infection were included to receive meropenem intravenously according to regimen of 2g q8h, 1g q8h or 1g q6h. After infusion of 4 doses, blood and CSF samples were collected simultaneously at predefined timepoints. High-performance liquid chromatography ultraviolet method was used to determine the concentration of meropenem. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02506686
Study type Interventional
Source Huashan Hospital
Contact
Status Completed
Phase Phase 4
Start date September 2008
Completion date December 2009
View Details
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