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Clinical Trial Summary

The primary objective of the study is to determine the effect of pozelimab on active CD55-deficient protein-losing enteropathy (PLE; CHAPLE). The secondary objectives of the study are: - To evaluate the safety and tolerability of pozelimab in patients with CD55-deficient PLE disease - To evaluate the effect of pozelimab on CD55-deficient PLE (both patients with active disease at baseline and those with inactive disease on eculizumab, switching to pozelimab) - To determine the effects of pozelimab on albumin and other serum proteins (total protein, immunoglobulins) - To determine the effects of pozelimab on ascites - To determine the effects of pozelimab on stool consistency - To determine the effect of pozelimab on health-related quality of life - To determine the effect of pozelimab on lab abnormalities observed in CD55-deficient PLE such as hypertriglyceridemia, thrombocytosis, and hypovitaminosis B12 - To describe the effects of pozelimab on the sparing of concomitant medications and reduction in hospitalization days - To determine the effects of pozelimab on growth - To characterize the concentration of pozelimab in patients with CD55-deficient PLE - To assess the incidence of treatment-emergent ADA for pozelimab in patients with CD55-deficient PLE disease


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04209634
Study type Interventional
Source Regeneron Pharmaceuticals
Contact
Status Completed
Phase Phase 2/Phase 3
Start date January 27, 2020
Completion date May 2, 2024

See also
  Status Clinical Trial Phase
Available NCT06003881 - Compassionate Use of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy