Cartilage Diseases Clinical Trial
Official title:
Molecular Biomarkers Associated With Degenerative Joint Disease
Verified date | October 2009 |
Source | Scuderi, Gaetano J., M.D. |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy. The presence of the complex in the synovial fluid of the knee is sensitive and specific for the painful state compared with similar aged controls. The absence of the complex in asymptomatic controls makes it a useful biomarker for the disease state.
Status | Completed |
Enrollment | 40 |
Est. completion date | March 2009 |
Est. primary completion date | January 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - the presence of mechanical symptoms including locking, catching, or giving way; - positive physical exam findings including joint line tenderness, McMurray's exam, or Steinman's exam; and - MRI of the knee positive for meniscus tear in a location correlating with physical examination. Exclusion Criteria: - the presence of high grade gonarthrosis including Kellgren-Lawrence grade IV; - a history of prior knee surgery or trauma; ligamentous incompetence on examination or MRI; and - diagnosis of inflammatory arthritides, crystalline arthropathies, or other rheumatologic diseases. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Scuderi, Gaetano J., M.D. | Stanford University |
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