Cartilage Diseases Clinical Trial
Official title:
Molecular Biomarkers Associated With Degenerative Joint Disease
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy. The presence of the complex in the synovial fluid of the knee is sensitive and specific for the painful state compared with similar aged controls. The absence of the complex in asymptomatic controls makes it a useful biomarker for the disease state.
Background: Molecular biomarkers associated with knee pain may be useful as diagnostic
tools, prognostic indicators, and surrogate endpoints for therapeutic trials. This study
describes a novel complex of structural degradation proteins which are present in the knees
of patients with meniscal pathology.
Methods: This prospective cohort study included 30 patients with knee pain, mechanical
symptoms, and MRI positive for meniscus tear who elected for arthroscopic partial
meniscectomy after failing conservative management. Synovial fluid was aspirated at the time
of surgery and assayed for a complex of structural degradation proteins by means of
heterogeneous ELISA. The results were compared to knee aspirates from 10 asymptomatic
volunteers with no pain. The complex was identified by a proteomic analysis of including
multiplexed-bead immunoassay, purification by anion exchange and size exclusion
chromatography, and mass spectrometry of individual chromatographic fractions.
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Observational Model: Cohort, Time Perspective: Prospective
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