Neuromuscular Ultrasound in Correlation to Neurophysiological Findings

Carpal Tunnel Syndrome Clinical Trial

Official title:

Neuromuscular Ultrasound Changes in Neuropathies in Correlation to Neurophysiological Findings

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04092140
• Other study ID #: ultrasound in neuropathies
• Status: Not yet recruiting
• Start date: October 1, 2019
• Est. completion date: November 2022

Study information

• Verified date: September 2019
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

1. Study the neuromuscular ultrasound findings in different types of neuropathies

2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases

3. correlation between clinical pain scale and severity of neuropathy

Description:

Ultrasonography is a diagnostic tool that is increasingly used in the work-up of peripheral nerve disease.

As many peripheral nerves run a superficial course, especially in the arms. This is a big advantage over Magnetic Resonance Imaging that is relatively expensive, time consuming and not readily available everywhere.

Nerve cross-sectional area (CSA) can be determined at multiple sites along the nerve.

CSA can be measured at entrapment sites but also at nonentrapment sites. vascularization, echogenicity, fascicular pattern and endoneurial thickness can be investigated as well. All those modalities can give critical insight in the origin and development of various peripheral neuropathies1,2,3

Major peripheral nerves in the extremities, such as the median,ulnar thick enough to reflect the sound beam, resulting in hyperechoic on the US scan 4.

The correlation between nerve conduction study parameters and CSA in ultrasound Ultrasound of the peripheral nervous system is an additional useful diagnostic tool in neuromuscular disorders..5,6,7,8,9 In the longitudinal plane, nerves present as long, slim structures with a mixture of parallel hypoechoic and hyperechoic lines.

Nerves must be distinguished from other nearby structures to ensure correct identification Muscles are hypoechoic and interspersed with small hyperechoic foci which easily distinguishes muscles from nerves. Tendons, which are sometimes adjacent to nerves, move proportionately with joint movement.

US has higher specificity than sensitivity in differentiating myopathic and neuropathic changes The most sensitive diagnostic marker for symptomatic carpal tunnel syndrome patients is an enlarged crosssectional area of the median nerve 10,11,12

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: November 2022
• Est. primary completion date: October 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• above 18 years old

• males or females

• diabetic complaining of neuropathy or not

• carpal tunnel syndrome

• Guillain-Barré syndrome

Exclusion Criteria:

• Patient refuse to participate

• The anatomy is altered due to sever trauma,tumor,or surgery

• Severe spasticity preventing examination

Related Conditions & MeSH terms

• Carpal Tunnel Syndrome
• Diabetic Neuropathies
• Guillain-Barre Syndrome
• Syndrome

Intervention

Device:
• ultrasound
easy new non invasive tool

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nerve ultrasound	on median and ulnar nerves	3 years
Primary	muscle Ultrasound	on thenar and hypothenar muscles	3 years
Primary	nerve conduction studies	for median and ulnar nerves (sensory and motor)	3 years
Primary	Electromyogram	for thenar and hypothenar	3 years