Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Carpal Tunnel Syndrome Clinical Trial

Official title:

Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00929123
• Other study ID #: R21AT002796
• Secondary ID: R21AT002796R21AT
• Status: Completed
• Phase: Phase 1/Phase 2
• First received: June 25, 2009
• Last updated: March 12, 2015
• Start date: May 2007
• Est. completion date: June 2009

Study information

• Verified date: March 2015
• Source: University of Florida
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: June 2009
• Est. primary completion date: July 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• 18 to 70 years of age

• signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion Criteria:

• non english speaking

• prior surgery for carpal tunnel syndrome

• systemic condition known to affect sensation

• chronic pain condition other than carpal tunnel syndrome

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Carpal Tunnel Syndrome
• Chronic Pain

Intervention

Procedure:
• neural mobilization
manual therapy technique known to directly stress the median nerve
• sham neural mobilization
sham technique mimicking the neural mobilization which is not specific to the median nerve

Other:
• healthy controls
People without carpal tunnel syndrome for comparison

Locations

Country	Name	City	State
United States	University of Florida	Gainesville	Florida

Sponsors (2)

Lead Sponsor	Collaborator
University of Florida	National Center for Complementary and Integrative Health (NCCIH)

Country where clinical trial is conducted

United States, 

References & Publications (3)

Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. Man Ther. 2009 Oct;14(5):531-8. doi: 10.1016/j.math.2008.09.001. Epub 2008 Nov 21. — View Citation

Bialosky JE, Bishop MD, Price DD, Robinson ME, Vincent KR, George SZ. A randomized sham-controlled trial of a neurodynamic technique in the treatment of carpal tunnel syndrome. J Orthop Sports Phys Ther. 2009 Oct;39(10):709-23. doi: 10.2519/jospt.2009.311 — View Citation

Bialosky JE, Bishop MD, Robinson ME, Price DD, George SZ. Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention. Man Ther. 2011 Dec;16 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	thermal and pressure pain sensitivity		immediate effect	No
Secondary	grip strength		3 weeks	No
Secondary	wrist range of motion		3 weeks	No
Secondary	clinical pain		3 weeks	No
Secondary	self report of disability		3 weeks	No
Secondary	median nerve function		3 weeks	No