Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Carotid Stenosis Clinical Trial

— MASCADI  

Official title:

Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03202823
• Other study ID #: MENEGAUT 2016
• Status: Completed
• Start date: April 13, 2017
• Est. completion date: December 11, 2020

Study information

• Verified date: January 2021
• Source: Centre Hospitalier Universitaire Dijon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 204
• Est. completion date: December 11, 2020
• Est. primary completion date: December 11, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients who have provided explicit consent

• Patients older than 18 years

• Patients about to undergo surgery for carotid stenosis

• Haemoglobin = 7g/dl at the time the sample is taken

• Respect the maximum volume of blood taken (treatment + research) in 30 days

SPECIFIC TO DIABETICS

• Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier

Exclusion Criteria:

• Patients under guardianship

• Patients without health insurance cover

• Pregnant or breast-feeding women

Related Conditions & MeSH terms

• Carotid Stenosis
• Constriction, Pathologic

Intervention

Procedure:
• blood samples
3 tubes (5 ml volume) collected during surgery
• recover samples of atheromatous plaque
a carotid sample collected during surgery

Locations

Country	Name	City	State
France	Chu Dijon Bourgogne	Dijon

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects		Baseline