Carotid Stenosis Clinical Trial
Official title:
Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis
PURPOSE: The purpose of this clinical trial is to study the cost-effectiveness ratios of
diagnostic strategies for the imaging assessment of symptomatic carotid stenosis.
MATERIALS AND METHODS: The diagnostic accuracies of Doppler ultrasound (DUS),
contrast-enhanced magnetic resonance angiography (CEMRA) and computed tomography angiography
(CTA) were compared with digital subtraction angiography (DSA) in a multicenter study
(CARMEDAS; 206 patients assessable) and in a meta-analysis (for CEMRA and CTA). The direct
costs of each imaging method were calculated in 2 university medical centers. Eight
hypothetical models were studied with DUS considered as the first-line imaging method and
either CEMRA or CTA or DSA as the second or third line method. The effectiveness criterion
was the number of potential avoided strokes for each strategy and for 1000 patients.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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