Physiopathological and Therapeutic Value of microRNA in the Progression of Carotid Artery Plaques: Carotid Protocol and microRNA

Carotid Arteries Clinical Trial

— CAMIA2  

Official title:

Physiopathological and Therapeutic Value of microRNA in the Progression of Carotid Artery Plaques: Carotid Protocol and microRNA

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02804659
• Other study ID #: PI2014_843_0024
• Status: Recruiting
• Start date: July 2013
• Est. completion date: March 2019

Study information

• Verified date: August 2018
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: Pierre MAITRIAS, PhD
• Phone: +33 3 22 08 72 67
• Email: maitrias.pierre[@]chu-amiens.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Molecular analysis of the atheroma plaque. Screening for a novel biomarker of carotid status.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: March 2019
• Est. primary completion date: March 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults having to undergo carotid thromboendarteriectomy

• social security coverage

• provision of study information

• consent to participation.

Exclusion Criteria:

• Previous carotid artery surgery

• refusal to participate in the study

• or inability to give consent.

Related Conditions & MeSH terms

• Carotid Arteries
• Carotid Stenosis

Intervention

Other:
• microRNA
Extraction of the microRNA using the mirVana miRNA isolation kit and quantification using real-time PCRs

Locations

Country	Name	City	State
France	CHU Amiens	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	expression level of the seven miRNAs of interest	expression level of the seven miRNAs of interest in the serum and in carotid artery plaques : miR-100, miR-125a, miR-127, miR-133a, miR-145, miR-221	Day of surgery