Clinical Trials Logo

Clinical Trial Summary

The purpose of this trial is to evaluate the efficacy of photobiomodulation of the major salivary glands on salivary parameters in children with caries activity.


Clinical Trial Description

Dental caries represents one of the most prevalent diseases among children around the world. Saliva plays a preponderant role in the process of demineralization- remineralization of the dental surface. Patient salivary characteristics, such as flow rate, pH, and buffering capacity, provide relevant information about patient's risk for developing carious lesions. Photobiomodulation has shown promising results to improve salivary flow rate, as well as buffer capacity in the adult population. The purpose of this trial is to evaluate the efficacy of photobiomodulation of the major salivary glands on salivary parameters in children with caries activity. Methods: This protocol details a randomized, double-blind, parallel-group, controlled trial evaluating salivary parameters through photobiomodulation in children. Seventy-eight 6- to 12-year-old participants will be randomly divided in two groups: 1) the photobiomodulation experimental group (G1) (n=39), 2) the photobiomodulationn placebo group (G2) (n=39). Infrared light will be applied in 16 intra and extraoral points and the placebo, respectively. The unstimulated salivary sample will be taken before and immediately after the application once a week, for three consecutive weeks. Salivary samples will be analyzed for flow rate, pH and buffering capacity. The primary outcomes are difference in salivary flow rates between the G1 and the G2. The secondary outcomes are difference in salivary pH and buffering capacity between the G1 and the G2 group. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05546528
Study type Interventional
Source University of Nove de Julho
Contact Lara J Motta, PhD
Phone 11998829511
Email larajmotta@terra.com.br
Status Recruiting
Phase N/A
Start date January 20, 2023
Completion date November 20, 2023

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05792800 - Dental Practitioners KAP Regarding Caries Preventive Measures in Cairo and Riyadah
Not yet recruiting NCT05792215 - KAP of Dental Practitioners Regarding CRA
Withdrawn NCT04104789 - Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General Phase 2
Active, not recruiting NCT06211582 - Clinical Performances of 3-different Tooth-colored Restorative Materials in Class-II Cavities N/A
Active, not recruiting NCT04342858 - Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment Phase 2
Recruiting NCT05362461 - Diagnostic Ability of Near Infrared Transillumination Detecting Interproximal Caries as Compared to Conventional Bitewing Radiographs
Not yet recruiting NCT04422860 - Remineralization Efficacy of Gum Arabic Varnish. Phase 2/Phase 3
Not yet recruiting NCT06063239 - Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial. N/A
Completed NCT04286256 - Using Motivational Interviewing To Reduce Parental Risk-Related Behaviors For Early Childhood Caries N/A
Completed NCT06182267 - Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101 Phase 1
Not yet recruiting NCT03671200 - Correlation Between Caries Experience in Primary Molars and First Permanent Molars
Not yet recruiting NCT06365281 - Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo University
Completed NCT06242184 - Post-operative Sensitivity in Resin Composites N/A
Completed NCT04003493 - LifE Style, Nutrition and Oral Health in Care Givers (LENTO) N/A
Enrolling by invitation NCT04251858 - Evaluation of Oral Condition and the Effect of Dental Treatment on Physical Parameters of Athletes N/A
Terminated NCT01796106 - Clinical Trial Proximal Caries Infiltration and Detection N/A
Not yet recruiting NCT05943782 - Evaluation of CAD/CAM Onlays Fabricated by Subtractive Versus Additive Digital Manufacturing Techniques. N/A
Recruiting NCT06114030 - Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation N/A
Recruiting NCT05756413 - Birth to Three - Cavity Free N/A
Completed NCT05231330 - Clinical Evaluation of Silver Nanoparticles in Comparison to Silver Diamine Fluoride in Management of Deep Carious Lesions N/A