Remineralization Effects of Hydroxyapatite Toothpaste

Status Completed

Clinical Trial Summary

The objective of this in situ clinical study is to determine whether a toothpaste containing hydroxyapatite microclusters is as effective as a fluoridated kid's toothpaste in promoting remineralization of early caries lesions and inhibiting the development of caries lesions.

Clinical Trial Description

The investigators hypothesize that (1) both the hydroxyapatite and the fluoridated toothpaste promote caries remineralization that is significantly greater than zero, and (2) the two toothpaste formulations are equally effective with respect to post-treatment remineralization and inhibition of demineralization.

- Non-inferiority will be considered established if there is no statistically significant difference in percentage of remineralization between the hydroxyapatite-containing toothpaste and the fluoridated kid's toothpaste for any one measurement method.

- Superiority/inferiority will be considered established if at least 20% statistically significant difference is observed between the hydroxyapatite-containing toothpaste and the fluoridated kid's toothpaste for any one measurement method ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03681340
Study type	Interventional
Source	Dr. Kurt Wolff GmbH & Co. KG
Contact
Status	Completed
Phase	N/A
Start date	August 7, 2018
Completion date	June 1, 2019

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