Health Effects of Silver-Mercury Dental Fillings

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether there are detectable health effects of low-level mercury exposure (from normal exposure to mercury-containing dental fillings) in the known target organs/systems affected by elemental mercury exposure.

Clinical Trial Description

The Casa Pia Study of the Health Effects of Dental Amalgam in Children is a randomized, prospective clinical trial with the overall goal of determining if there are detectable health effects due to exposure from mercury-containing dental amalgam fillings. Children, thought to be the population most susceptible to any possible health effects, were randomly assigned to one of two treatment groups (total n=507). Subjects were originally enrolled at ages between 8-10 years of age. To participate, subjects must have: Dental caries in at least one posterior tooth; no prior exposure to dental amalgam; a blood lead of <15ug/L; a urinary mercury level of <10ug/L; an IQ as measured by the CTONI of >67; and no prior or existing serious medical or neurologic condition. One group received only dental filling materials other than those containing mercury (plastic and ceramic composites), while the other group received mercury amalgam fillings where appropriate (in large restorations in back teeth), but the alternative materials everywhere else. Both treatment regimens are standard-of-care throughout the world. Subjects receive ongoing dental care via the study clinics, and continue to receive dental fillings as needed based on group assignment. The target organs of mercury exposure are renal and neurological. Baseline and annual repeated measures are taken on all subjects for renal function, nerve conduction velocity and a large battery of neurobehavioral tests. Follow-up is planned for a period of 7 years ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00066118
Study type	Interventional
Source	University of Washington
Contact
Status	Completed
Phase	Phase 3
Start date	August 1996
Completion date	February 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03004196` - Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans	Phase 1/Phase 2
Completed	`NCT03119779` - Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars	N/A
Not yet recruiting	`NCT03590977` - Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients	N/A
Completed	`NCT03694496` - The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong	N/A
Completed	`NCT03412721` - Effectiveness of Er:YAG Pulse Therapy for Achieving Pre-emptive Dental Analgesia in Children	N/A
Completed	`NCT03552835` - Management of Occlusal Dentinal Caries in Deciduous Molars	N/A
Completed	`NCT03426046` - Treatment of Immature Permanent Teeth With Three Different Pulp Capping Materials With Partial Pulpotomy	Phase 4
Completed	`NCT00966394` - Salivary Bacteria and Oral Health Status in Children With ADHD	N/A
Completed	`NCT03062605` - Reducing Bacteria That Cause Tooth Decay	Phase 3
Recruiting	`NCT03586713` - Accuracy Of Sopro-Life Camera In Comparison With ICDAS II For Detection Of Initial Caries	N/A
Withdrawn	`NCT00973089` - Alternative Treatment of Deep Carious Lesions Based on Biological Evidences	N/A
Not yet recruiting	`NCT05306691` - Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients	Early Phase 1
Completed	`NCT02333227` - Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi	N/A
Completed	`NCT03294590` - Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children	N/A
Recruiting	`NCT03108313` - Role of Aloe Vera Versus Fluoride Toothpaste in Changing High to Low Salivary Bacterial Count	Phase 2
Active, not recruiting	`NCT02958891` - Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits	N/A
Completed	`NCT03667768` - Atraumatic Restorative Treatment Sealants in First Permanent Molars	N/A
Completed	`NCT03660410` - Study of Oral Conditions in Indigenous Populations in the State of Roraima - Brazil
Completed	`NCT03078179` - Effect of Lactobacillus Rhamnosus GG and Bifidobacterium Longum in Children Aged 3 to 5 Years of Villavicencio and Pasto	N/A
Completed	`NCT02494193` - Indirect Pulp Capping With Resin Modified Glass Ionomer	N/A