Cardiovascular Risk Factor Clinical Trial
Official title:
The Role of Potassium Supplementation on Endothelial Function, BP Regulation, and Oxidative Stress Under High Sodium Conditions
NCT number | NCT05887622 |
Other study ID # | 1465208 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | January 24, 2022 |
Est. completion date | June 30, 2025 |
This study will test whether potassium supplementation can reduce the deleterious effect of a high sodium diet on blood vessel function, blood pressure reactivity and autonomic nervous system function in apparently healthy adults.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | June 30, 2025 |
Est. primary completion date | January 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - men and women - 18-45 years of age - all races/ethnicities - BMI < 30 kg/m2 - BP < 130/80 mmHg Exclusion Criteria: - presence of hypertension - known heart disease - diabetes - kidney disease - cancer - inflammatory conditions - blood clotting disorders - pregnancy - adrenal gland disorder - history of stomach or intestinal bleeding - history of kidney stones - serum potassium outside of the normal range |
Country | Name | City | State |
---|---|---|---|
United States | Tower at STAR | Newark | Delaware |
Lead Sponsor | Collaborator |
---|---|
University of Delaware |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Conduit artery endothelial dependent dilation | The difference in flow-mediated dilation (FMD) between the 3 diets | on day 10 of each diet | |
Primary | Blood pressure reactivity | The change in both systolic and diastolic blood pressure during handgrip exercise and cold pressor test from baseline | on day 10 of each diet | |
Primary | Superoxide levels | The difference in superoxide levels as measured by electronic paramagnetic resonance (EPR) between the 3 diets will be assessed | on day 10 of each diet |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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