Cardiovascular Risk Factor Clinical Trial
Official title:
A Randomised, Double-blinded, Cross-over, Placebo- Controlled Pilot Study to Investigate the Effect of Tomato Extract on TMAO in Overweight or Obese Adults
To determine the effect of 4 weeks daily consumption of Fruitflow on changes in plasma levels of fasting Trimethylamine N-oxide concentrations (TMAO)
Tomatoes contain a range of polyphenols that are of low bioavailability and reach the colon.
Data from animal studies suggest that certain polyphenols are extensively metabolized by the
gut microbiota which may impact bioactivity including TMA/TMAO production. It was previously
shown that a polyphenol-rich cranberry extract attenuated diet-induced metabolic syndrome in
mice in a gut microbiota-dependent manner. In another mouse study the polyphenol resveratrol
attenuated TMAO-induced atherosclerosis by decreasing TMAO levels and increasing hepatic bile
acid neosynthesis via gut microbiota remodelling. However, human studies on polyphenol effect
on TMAO levels and the gut microbiome are sparse. In a recent study TMAO serum levels were
reduced in healthy subjects upon supplementation with a grape pomace polyphenolic extract.
This clinical study will provide new insight into the effect of tomato extract on TMAO levels
and the gut microbiota composition and thus potential new mechanisms responsible for the
cardiovascular protective effects.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
| Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Recruiting |
NCT04481503 -
Transthoracic Echocardiography of Ventricular Function of Parturients in Labor
|
||
| Terminated |
NCT04088240 -
Effects of Omega-3 Docosapentaenoic Acid on Lipids and Other Risk Factors for Cardiovascular Disease
|
N/A | |
| Completed |
NCT03410342 -
The Effects of Types of Fruits and Vegetables on Vascular Function
|
N/A | |
| Completed |
NCT03170752 -
Implementing and Testing a Cardiovascular Assessment Screening Program (CASP)
|
N/A | |
| Recruiting |
NCT04231838 -
Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems
|
N/A | |
| Active, not recruiting |
NCT03902431 -
Translating the ABCS Into HIV Care
|
N/A | |
| Terminated |
NCT03517111 -
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
|
N/A | |
| Completed |
NCT04562467 -
The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk
|
Phase 4 | |
| Completed |
NCT03429920 -
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
|
N/A | |
| Completed |
NCT04551872 -
RESILIENCE: Personalizing Cardiovascular Health
|
N/A | |
| Enrolling by invitation |
NCT03314818 -
Natural History of Carotid Plaque as Determined by 3D Ultrasound
|
N/A | |
| Completed |
NCT03060811 -
Mediterranean Diet, Trimethylamine N-oxide (TMAO) and Anti-oxidants in Healthy Adults
|
N/A | |
| Completed |
NCT04279704 -
Overcoming Obstacles in Epigenetic Analysis of Human Twins
|
||
| Completed |
NCT01050205 -
The Healthy Lifestyle Project
|
N/A | |
| Completed |
NCT03570840 -
Pediatric Metabolic Syndrome Study
|
||
| Completed |
NCT03039023 -
Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans
|
N/A | |
| Completed |
NCT04353700 -
Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health
|
N/A |