Factors Influencing Cardiovascular Prognosis — Pythia-GR  

Cardiovascular Mortality Clinical Trial

Official title: Factors Influencing Cardiovascular Prognosis in Hypertensive Patients (Pythia Study)

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to identify risks for cardiovascular events in a follow up period of 10 years.

Clinical Trial Description

Inclusion criteria

• Age > 50 years volunteers (2 towns of 15000 residents one in the north and one in the south of Greece)

• End points

• 5-10 years cardiovascular morbidity and mortality

Measurements at baseline

• Anthropometrics

• Age (M>55 years; W>65 years)

• Weight-height- BMI

• Abdominal obesity (Waist circumference>102 cm(M), >88cm (W) Family history

• Family history of premature CV disease (M at age<55 years; W at age<65 years)

History

• Smoking

• Diabetes Mellitus,

• Established Heart disease: myocardial infarction; angina; coronary revascularization; heart failure

• Established renal disease [diabetic nephropathy; renal impairment (serum creatinine M>133, W>124 mmol/l); proteinuria (> 300 mg/24 h)]

• Cerebrovascular disease: ischaemic stroke; cerebral haemorrhage; transient ischaemic attack

• Peripheral artery disease

• Advanced retinopathy: haemorrhages or exudates, papilloedema

• Treatment

Measurements

• Measurements Blood pressure

• Clinic BP

• 24h ABPM

• Home BP

Heart

• Electrocardiographic LVH

• Echocardiographic LVH

Vessels

• Carotid wall thickening or plaque

• Carotid-femoral pulse wave velocity

• Ankle/brachial BP index

Lipids or other risk factors

• Total cholesterol, Tg, HDL, LDL

• Plasma creatinine, estimated glomerular filtration rate

• Fasting plasma glucose or postload plasma glucose

• Microalbuminuria and albumin-creatinine ratio

• Glucose tolerance test

• Follow up each 3 year with all the above measurements ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Cardiovascular Mortality

• NCT number: NCT00973206
• Study type: Observational
• Source: Aristotle University Of Thessaloniki
• Contact: Vasilios Kotsis, Prof
• Phone: 6974748860
• Email: vkotsis@auth.gr
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 2017
• Completion date: January 2027