The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

Cardiovascular Diseases Clinical Trial

Official title:

The Effect of Arterial Oxygen Levels on Thiol Disulfide Homeostasis and Ischemia Modified Albumin in Coronary Artery Bypass Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04627220
• Other study ID #: Bursa High Education Hospital
• Status: Completed
• Start date: January 1, 2020
• Est. completion date: November 1, 2020

Study information

• Verified date: November 2020
• Source: Bursa Yüksek Ihtisas Education and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Description:

Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: November 1, 2020
• Est. primary completion date: October 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• patient scheduled for cardiac surgery

• ASA>3

• Aged 18-75 years

Exclusion Criteria:

• those with valvular disease

• EF<%40

• BMI>40 kg/m2

• presence of arrhythmia that impairs hemodynamics

• previous history of cerebrovascular

• diagnosed with end-stage organ failure

Related Conditions & MeSH terms

• Cardiovascular Diseases

Intervention

Diagnostic Test:
• taken venous sample
Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

Locations

Country	Name	City	State
Turkey	University of Health Sciences Bursa Yüksek Ihtisas Training and Research Hospital	Bursa

Sponsors (1)

Lead Sponsor	Collaborator
Bursa Yüksek Ihtisas Education and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	assessment of oxidative damage	To measure the degree of oxidative damage in the patient's blood at different oxygen values used in cardiac bypass surgeries with thiol disulfide homeostasis and ischemia-modified albumin at times determined.	48 hours after operation