Cardiovascular Diseases Clinical Trial
Official title:
Musical Heart Rhythm Regulation: The MUSIC-HR Study
Verified date | February 2020 |
Source | Chelsea and Westminster NHS Foundation Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The idea that music has an effect on heart rate and blood pressure has existed for some time.
In 1918, Hyde and Scalapino [1] reported that minor tones increased pulse rate and lowered
blood pressure, whereas "stirring" music increased both blood pressure and heart rate. In the
management of many cardiovascular disorders heart rate control is paramount. Furthermore,
many cardiovascular investigations (e.g. Cardiac CT) require adequate heart rate control in
order to achieve diagnostic images and therefore results. Whilst pharmacologic therapy is
available and remains the main strategy for heart rate control, this is not always without
consequences. Side effect profiles, patient intolerance and also variable efficacy are
limiting factors for pharmacological therapy. Alternative strategies to achieve adequate
heart rate control are therefore needed.
The aim of this study is to explore the potential use of music to control heart rates and
other physiological parameters such as respiratory rate and blood pressure. The central study
team hypothesize that by changing the tempo of the music they will be able to influence the
natural variations in heart rate.
1. Hyde IM, Scalapino W. The influence of music upon electrocardiograms and blood pressure.
Am J Physiol.1918Íž46:35-38.
Status | Completed |
Enrollment | 19 |
Est. completion date | September 30, 2019 |
Est. primary completion date | July 12, 2019 |
Accepts healthy volunteers | |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Employed by Chelsea and Westminster NHS Foundation Trust with any contract type (substantive, fixed term, honorary or bank) - Age 18 or above - Capable of giving informed consent - Normal 12 lead ECG and blood pressure recording Exclusion Criteria: - Under 18 years of age - Incapable of giving informed consent - Regular use of any medications that interact with physiological control of the parameters being measured - Hearing impairment - Skin sensitivity to ECG electrodes |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Chelsea and Westminster Hospital | London | Greater London |
Lead Sponsor | Collaborator |
---|---|
Chelsea and Westminster NHS Foundation Trust | CW Plus Charity |
United Kingdom,
Hyde IM, Scalapino W. The influence of music upon electrocardiograms and blood pressure. Am J Physiol. 1918;46:35-38.
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of the effect of music and music tempo on heart rate control | After a period of approximately 10 minutes of ECG recording without music (control period), a series of pieces of music will be played whilst the ECG recordings continue. Each piece of music will last for no more than 5 minutes, 3 will be selected by the investigators and one will be pre-chosen by the participant prior to their attendance. The order in which these pieces will be played will be chosen at random. There will be a 3 minute recovery time in between each piece of music. The same pieces of music will then be played back to the participant but this time the music will subtly change tempo in reaction to the patient's heart rate. This is achieved by the ECG feeding data into the computer playing the music, whereupon the data is processed by Max MSP software and used to control the playback speed in Ableton Live. The algorithm for change is a linear one: the higher a patient's heart rate is in relation to a desired bpm target, the more the music will slow down. | Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. | |
Secondary | Assessment of the effect of music and music tempo on blood pressure and variability | As well as having an ECG recording performed, participants will also have a continuous non-invasive blood pressure recording using equipment that is in routine clinical practice (Finapress BP) and respiration monitored via a respiration belt. They will also be asked to wear a small lightweight sensor that gives readings of heart rate and blood pressure at 2 minute intervals. The data obtained from all of the physiological recordings with be analysed for associations. |
Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. | |
Secondary | Assessment of the effect of music on heart rate variability | As well as having an ECG recording performed, participants will also have a continuous non-invasive blood pressure recording using equipment that is in routine clinical practice (Finapress BP) and respiration monitored via a respiration belt. They will also be asked to wear a small lightweight sensor that gives readings of heart rate and blood pressure at 2 minute intervals. The data obtained from all of the physiological recordings with be analysed for associations. |
Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. | |
Secondary | Assessment of the effect of music on markers of repolarization instability | Effect of music on markers of repolarization instability (QT interval and T wave vector assessment). | Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. | |
Secondary | Effect of music on cardiac autonomics | This is assessed by frequency analysis of ECG. | Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. | |
Secondary | Assessment of the effect of music and music tempo on respiratory rate and variability | Respiration of participants will be monitored via a respiration belt whilst they are listening to music. | Participants will be involved in the study for a total of 1 day. No follow-up is required so data will be ready for analysis after participants have completed the music exercise. |
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