The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery

Cardiovascular Diseases Clinical Trial

Official title:

The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03656757
• Other study ID #: 2017/767
• Status: Completed
• Start date: January 2, 2019
• Est. completion date: March 13, 2019

Study information

• Verified date: March 2019
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will assess the amount of energy that the heart will deliver to the central circulation and the efficiency of that energy transfer, in patients undergoing a coronary artery bypass graft operation. Measurements will be taken just after induction of anaesthesia and repeated just after the end of the operation. The total energy delivered by the heart will be calculated by multiplying a pressure curve from the artery in the hand with the instantaneous ultrasound recorded cardiac output flow curve. The energy responsible for the acceleration of the blood volume, known as oscillatory power will also be calculated. The energy transfer will be calculated using a mathematical model based upon other ultrasound and blood pressure recorded variables. We would like to see if any alteration in energy delivered is in part due to impairment in energy transfer or alteration of fraction of oscillatory power rather than a change in total energy production. We would also like to study if there are changes in the oscillatory power after cardiac bypass surgery. The patients will be sampled sequentially into the study. We are not aware of any such studies undertaken in humans previously.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: March 13, 2019
• Est. primary completion date: March 13, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Elective Coronary Artery Bypass Graft patients

• No contraindications to transoesophageal Echo

• Ejection fraction 40% or over

Exclusion Criteria:

• Lack of consent

• Emergency operation

• Prosthetic aortic valve

Related Conditions & MeSH terms

• Cardiovascular Diseases

Locations

Country	Name	City	State
Norway	St Olavs Hospital	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Arterioventricular coupling	The ratio between arterial elastance and ventricular elastance	1 day
Primary	Total Cardiac Power	The amount of energy per second delivered from the left ventricle to the arterial circulation	1 day
Primary	Oscillatory Cardiac Power	The part of total cardiac power which is responsible for acceleration of the blood volume during systole.	1 day
Secondary	Cardiac Output	The hearts delivery of volume per minute	1 day
Secondary	Heart rate	The amount of heart beats per minute	1 day
Secondary	Systemic vascular resistance	The resistance to flow of the arterial tree	1 day