Cardiovascular Diseases Clinical Trial
Official title:
Medium-term Modulation of the Inflammatory Profile by Medium-cut Off Membranes in Patients With End Stage Renal Disease
This study examines whether medium-cut off dialysis results in improved blood purification of large middle molecules e.g. inflammatory molecules compared to hemodialysis (HD) treatments with conventional high-flux dialyzers.
Cardiovascular events and sepsis remain the leading causes of mortality in patients on
maintenance hemodialysis. Thus expectancy of life for these patients is comparable to the
prognosis of metastasized cancer. So far the exact mechanisms causing excess mortality in
hemodialysis patients remain elusive, but chronic inflammation seems to play a central role
in the pathogenesis of cardiovascular disease in HD patients.
Keeping this in mind the Theranova medium-cut off membrane, with its ability to clear middle
molecules (0,5-50 kDa), seems suitable to further improve clearance of inflammatory mediators
as the non-protein bound inflammatory mediators lie within the cut off range of this
membrane. The investigators designed this study to get information on the changes in the
inflammatory milieu in dialysis patients when using medium-cut off membranes which are know
to significantly reduce cytokines compared to standard high-flux dialyzers.
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