Cardiovascular Diseases Clinical Trial
Official title:
In Vitro Study to Evaluate the Pharmacodynamic Interaction Between Ticagrelor and Its Active Metabolite (AR-C124910XX) and Their Effects on the Pharmacodynamics of Salicylic Acid : Concentration-antiplatelet Effect Relationships
This is a in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor and
its active metabolite (AR-C124910XX) and their effects on the pharmacodynamics of salicylic
acid. The study consist of two parts of in-vitro study as follows;
- Part 1 : in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor
and its active metabolite.
- Part 2 : in vitro study to evaluate the pharmacodynamic interaction between ticagrelor
and its active metabolite and their effect on the pharmacodynamics of salicylic acid on
platelet aggregation tests with the agonist of arachidonic acid.
This is a in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor and
its active metabolite (AR-C124910XX) and their effects on the pharmacodynamics of salicylic
acid. The study consist of two parts of in-vitro study as follows;
- Part 1 : in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor
and its active metabolite. Platelet aggregation tests with the agonist of adenosine
diphosphate(ADP) will be assessed on the in-vitro mixtures of blank plasma and
randomized paired concentrations of ticagrelor + AR-C124910XX.
- Part 2 : in vitro study to evaluate the pharmacodynamic interaction between ticagrelor
and its active metabolite. Platelet aggregation tests with the agonist of arachidonic
acid will be assessed on the in-vitro mixtures of blank plasma plus randomized paired
concentrations of ticagrelor and AR-C124910XX and the invitro mixtures with blank
plasma and ticagrelor + AR-C124910XX + salicylic acid.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT04056208 -
Pistachios Blood Sugar Control, Heart and Gut Health
|
Phase 2 | |
| Recruiting |
NCT04417387 -
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
|
||
| Not yet recruiting |
NCT06211361 -
Cardiac Rehabilitation Program in Patients With Cardiovascular Disease
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT04514445 -
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
|
||
| Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
| Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Completed |
NCT04083846 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
|
Phase 1 | |
| Completed |
NCT04083872 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
|
Phase 1 | |
| Completed |
NCT03619148 -
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
|
N/A | |
| Completed |
NCT03466333 -
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
|
Phase 2 | |
| Completed |
NCT03693365 -
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
|
||
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Completed |
NCT05132998 -
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
|
N/A | |
| Completed |
NCT05067114 -
Solutions for Atrial Fibrillation Edvocacy (SAFE)
|