Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

Cardiovascular Diseases Clinical Trial

Official title:

Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00010530
• Other study ID #: P50 AT000082-01P1
• Secondary ID: P50AT000082-01P5
• Status: Completed
• Phase: Phase 1
• First received: February 2, 2001
• Last updated: December 4, 2009
• Start date: September 1999
• Est. completion date: July 2006

Study information

• Verified date: December 2009
• Source: National Center for Complementary and Integrative Health (NCCIH)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).

Description:

Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.

Other known NCT identifiers

• NCT00009087

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: July 2006
• Est. primary completion date: July 2006
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• African-American (self-identified)

• Local residence

• Able to participate

• Coronary artery disease by MI, CABG, PTCA (>3 months prior), or angiography

• Consent and referring MD approval

Study Design

Allocation: Randomized, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Cardiovascular Diseases

Intervention

Procedure:
• Meditation

Locations

Country	Name	City	State
United States	Maharishi University of Management Center for Health and Aging Studies	Fairfield	Iowa
United States	Charles R. Drew University of Medicine and Science	Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
National Center for Complementary and Integrative Health (NCCIH)

Country where clinical trial is conducted

United States,