Cardiovascular Disease Clinical Trial
— REDEFINE 3Official title:
The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease
This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.
| Status | Recruiting |
| Enrollment | 7000 |
| Est. completion date | October 13, 2027 |
| Est. primary completion date | September 1, 2027 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 55 Years and older |
| Eligibility | Inclusion Criteria: - Male or female - Age above or equal to 55 years at the time of signing informed consent - Body mass index (BMI) greater than or equal to (>=) 25.0 kilograms per meter square (kg/m^2) - Established CVD as evidenced by at least one of the following: 1. Prior myocardial infarction 2. Prior stroke (ischemic or haemorrhagic stroke) 3. Symptomatic peripheral arterial disease (PAD) defined as at least one of the following: 1. Intermittent claudication with an ankle-brachial index (ABI) less than (<) 0.85 at rest 2. Intermittent claudication with a >= 50% stenosis in a lower extremity peripheral artery documented by X-ray angiography, magnetic resonance (MR) angiography, computed tomography (CT) angiography or Doppler ultrasound 3. Prior revascularization procedure of a lower extremity peripheral artery 4. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g., trauma or osteomyelitis) For participants with T2D at screening the following inclusion criteria also apply: - Diagnosed with type 2 diabetes mellitus (T2D) >= 180 days before screening - HbA1c 6.5%-10% (48-86 millimoles per mole [mmol/mol]) (both inclusive), as measured by central laboratory at screening - Treatment with either: 1. Lifestyle intervention alone 2. 1-3 marketed oral antidiabetic drugs (OADs) (metformin, a-glucosidase inhibitors (AGI), glinides, sodium-glucose co-transporter 2 inhibitor (SGLT2i), dipeptidyl peptidase 4 (DPP4)-inhibitors, thiazolidinediones, or sulphonylureas (SU) as a single agent or in combination) according to local label 3. Basal insulin alone or in combination with up to two marketed OADs, all according to local label Exclusion Criteria: - Myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within 60 days before screening - Planned coronary, carotid or peripheral artery revascularisation known on the day of screening - Heart failure classified as being in New York Heart Association (NYHA) Class IV at screening - Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or a medication with GLP-1 activity within 90 days before screening - End stage renal disease defined as estimated glomerular filtration rate (eGFR) < 15 millileters per minutes per 1.73^2 (mL/min/1.73 m^2), as measured by the central laboratory at screening - Chronic or intermittent haemodialysis or peritoneal dialysis |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli | Buenos Aires | |
| Argentina | CEMEDIC | Caba | Buenos Aires |
| Argentina | Centro de Investigación y Prevención Cardiovascular | Caba | |
| Argentina | Mautalen Salud e investigación | Caba | Buenos Aires |
| Argentina | Medical Center of Diabetes and Nutrition | Caba | |
| Argentina | Centro de Investigaciones Metabólicas | Capital Federal | |
| Argentina | Centro Médico Privado San Vicente Diabetes | Córdoba | |
| Argentina | Instituto Médico DAMIC | Córdoba | |
| Argentina | Hospital Italiano de la Plata | La Plata | Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas | Mar del Plata | |
| Argentina | Consultorio Integral de Atención al Diabético | Morón | |
| Argentina | Instituto Medico Catamarca | Rosario | Santa Fe |
| Argentina | Instituto de Investigaciones Clinicas San Nicolás | San Nicolás | |
| Argentina | Sanatorio Norte | Santiago del Estero | |
| Australia | Nightingale Research | Adelaide | South Australia |
| Australia | Royal Adelaide Hospital Cardiovascular Clinical Trials | Adelaide | South Australia |
| Australia | GenesisCare | Auchenflower | Queensland |
| Australia | Gosford Renal Research | Gosford | New South Wales |
| Australia | Royal Hobart Hospital | Hobart | Tasmania |
| Australia | HeartCare WA (Joondalup) | Joondalup | Western Australia |
| Australia | Paratus Clinical | Kanwal | New South Wales |
| Australia | Southern Neurology | Kogarah | New South Wales |
| Australia | HeartCare SA | Leabrook | South Australia |
| Australia | Liverpool Hospital | Liverpool | New South Wales |
| Australia | Macquarie University | Macquarie Park | New South Wales |
| Australia | Logan Hospital | Meadowbrook | Queensland |
| Australia | Baker IDI Heart and Diabetes Institute | Melbourne | Victoria |
| Australia | One Clinical Research | Nedlands | Western Australia |
| Australia | Clinitrials | Perth | Western Australia |
| Brazil | i9 Pesquisas Clínicas | Campinas | Sao Paulo |
| Brazil | Instituto de Pesquisa Clínica de Campinas | Campinas | Sao Paulo |
| Brazil | PUCCAMP - Hospital e Maternidade Celso Pierro | Campinas | Sao Paulo |
| Brazil | Núcleo de Pesquisa Clínica S/S | Curitiba | Parana |
| Brazil | Centro de Pesquisa em Diabetes Doenças Endócrino-Metabólicas | Fortaleza | CE |
| Brazil | Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda. | Porto Alegre | Rio Grande Do Sul |
| Brazil | Hospital São Lucas Copacabana | Rio de Janeiro | RJ |
| Brazil | CIP Centro Integrado de Pesquisas do Hospital de Base | São José do Rio Preto | Sao Paulo |
| Brazil | Instituto São José dos Campos em Pesquisas Médicas | São José dos Campos | Sao Paulo |
| Brazil | CEPIC - Centro Paulista de Investigacao Clinica | Sao Paulo | |
| Brazil | CPCLIN - Centro de Pesquisas Clínicas | São Paulo | Sao Paulo |
| Brazil | CPQuali Pesquisa Clínica Ltda | São Paulo | Sao Paulo |
| Brazil | Instituto de Pesquisa Clinica (IPEC) | São Paulo | Sao Paulo |
| Brazil | Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo | Vitória | Espirito Santo |
| Bulgaria | Specialized Rehabilitation Hospital Zdrave EAD | Bankya | |
| Bulgaria | Diagnostic Consultative Centre 1 Bourgas | Burgas | |
| Bulgaria | ET "Individual practice for specialized outpatient medical care - Dr. Georgi Marinov" | Burgas | |
| Bulgaria | Medical Centre Diamedical-2013 | Dimitrovgrad | |
| Bulgaria | Medical centre Asclepius | Dupnitsa | Kyustendil |
| Bulgaria | "Ambulatory for individual practice for specialized medical care - DiMed" EOOD | Haskovo | |
| Bulgaria | Medical centre "Zdrave 1" OOD | Kozloduy | |
| Bulgaria | "MHAT - UniHospital" OOD | Panagyurishte | |
| Bulgaria | "MHAT - Pazardzhik" | Pazardzhik | |
| Bulgaria | "Medical center Medconsult Pleven" OOD | Pleven | |
| Bulgaria | OCSOMCE - Dr. Albena Dinkova EOOD | Pleven | |
| Bulgaria | "UMHAT Plovdiv" AD | Plovdiv | |
| Bulgaria | 'MHAT Sveta Karidad' EAD | Plovdiv | |
| Bulgaria | Diagnostic Consulting Center Pulmed EOOD | Plovdiv | |
| Bulgaria | MHAT "Med Line Clinic" | Plovdiv | |
| Bulgaria | UMHAT "Kaspela", Depart. Endocrinology and Metab. Diseases | Plovdiv | |
| Bulgaria | UMHAT Pulmed, Endocrinology and Metabolic Diseases | Plovdiv | |
| Bulgaria | MHAT Medica - Ruse OOD | Ruse | |
| Bulgaria | ''Aipsomcidemd - Dr. Lilyana Bodurova-Troharova" Eood | Samokov | |
| Bulgaria | MHAT "Dr. Ivan Seliminski"-Sliven | Sliven | |
| Bulgaria | "Nader Yabrudi - ASMPVBE Individual practice" | Smolyan | |
| Bulgaria | "Medical Center Diamedical - 2013" OOD - Sofia | Sofia | |
| Bulgaria | Acibadem City Clinic MHAT Tokuda Department of Endocrinology | Sofia | |
| Bulgaria | Medical centre Vitclinic EOOD | Sofia | |
| Bulgaria | Medical Institute of Ministry of interior | Sofia | |
| Bulgaria | MHAT "Knyaginya Klementina" -Sofia EAD | Sofia | |
| Bulgaria | MHAT 'Sveta Sofia' EOOD | Sofia | |
| Bulgaria | Orthopaedic Center Kinov | Sofia | |
| Bulgaria | UMHAT "Sveti Ivan Rilski" | Sofia | |
| Bulgaria | UMHAT Aleksandrovska | Sofia | |
| Bulgaria | "Medical center Zara-Med" EOOD | Stara Zagora | |
| Bulgaria | "Prevencia-2000-MCOC" | Stara Zagora | |
| Bulgaria | "UMHAT- Prof. dr. Stoyan Kirkovich" | Stara Zagora | |
| Bulgaria | MBAL Trakia EOOD | Stara Zagora | |
| Bulgaria | Medical Center "Nov Rehabilitatsionen center" EOOD | Stara Zagora | |
| Bulgaria | UMHAT Sveta Marina EAD | Varna | |
| Bulgaria | Diagnostic Consulting Center 1 Velingrad EOOD | Velingrad | |
| Bulgaria | "MHAT "Sveti Panteleimon" - Yambol" AD | Yambol | |
| Bulgaria | Medical centre Runkovi OOD | Yambol | |
| Canada | Centricity Res. Barrie Endo | Barrie | Ontario |
| Canada | Centricity Research Brampton | Brampton | Ontario |
| Canada | Viacar Recherche Clinique Inc. | Brossard | Quebec |
| Canada | C-endo Diab Endo Clin Calgery | Calgary | Alberta |
| Canada | Centricity Research Calgary | Calgary | Alberta |
| Canada | Cambridge Cardiac Care Centre | Cambridge | Ontario |
| Canada | Nova Scotia Health Authority | Halifax | Nova Scotia |
| Canada | Hamilton Med Res Group | Hamilton | Ontario |
| Canada | Ctr de rech Clin de Laval | Laval | Quebec |
| Canada | Manna Research Mirabel | Mirabel | Quebec |
| Canada | G.A. Research Associates Ltd. | Moncton | New Brunswick |
| Canada | Applied Medical Informatics Research | Montreal | Quebec |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Diex Recherche Quebec Inc. | Quebec | |
| Canada | Institut universitaire de cardiologie | Quebec | |
| Canada | Recherche Clinique Sigma Inc. | Quebec | |
| Canada | Clin des Mal Lipid de Quebec | Québec | Quebec |
| Canada | CHU-Sherbrooke | Sherbrooke | Quebec |
| Canada | Ctr de méd métab de Lanaudière | Terrebonne | Quebec |
| Canada | Diabetes Heart Research Centre | Toronto | Ontario |
| Canada | Clinical Research Solutions Inc. | Waterloo | Ontario |
| Colombia | Clinica de la Costa | Barranquilla | |
| Colombia | Fundacion del Caribe para la Investigacion Biomedica-BIOS | Barranquilla | |
| Colombia | CentrodeInvestigaciónenReumatologíayEspecialidadesMédicas | Bogota | |
| Colombia | Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia | Bucaramanga-piedecuesta, Valle Del Menzuli - Santander | Santander |
| Colombia | FOSCAL | Floridablanca | Santander |
| Colombia | Somer Sociedad Medica Rionegro S.A. Somer S.A. | Rionegro | |
| Colombia | Fundación Hospital Universidad del Norte | Soledad | Barranquilla |
| Denmark | Aarhus Universitetshospital, Skejby Hjertesygdomme | Aarhus N | Region Midtjylland |
| Denmark | Aarhus Universitetshospital, Steno Diabetes Center Aarhus | Aarhus N | |
| Denmark | Herlev og Gentofte Hospital | Hellerup | Region Hovedstaden |
| Denmark | Regionshospitalet Gødstrup, Hjertesygdomme | Herning | |
| Denmark | Hillerød Endokrinologisk amb. H0652 | Hillerød | |
| Denmark | Holbæk Sygehus | Holbæk | Region Sjælland |
| Denmark | Kolding Sygehus Karkirurgi | Kolding | |
| Denmark | Slagelse Sygehus Ambulatorium for hjertesygdomme | Slagelse | |
| Denmark | Slagelse Sygehus Ambulatorium for hjertesygdomme | Slagelse | |
| Denmark | Kardiologisk Odense & Svendborg | Svendborg | Region South |
| Denmark | Viborg Sygehus | Viborg | |
| France | Centre Hospitalier d'Annonay | Annonay | |
| France | Centre Hospitalier Ardeche Nord | Annonay cedex | |
| France | Ap-Hp-Hopital Avicenne | Bobigny | |
| France | Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2 | Grenoble cedex 9 | |
| France | CH Louis Pasteur | Le Coudray | |
| France | Les Hopitaux de Chartres-Hopital Louis Pasteur | Le Coudray | |
| France | Groupe Hospitalier Du Havre | Le Havre | |
| France | Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez | Lille | |
| France | Centre Hospitalier Universitaire de Montpellier-Hopital Lapeyronie | Montpellier | |
| France | Aphp-Hopital La Pitie Salpetriere-2 | Paris | |
| France | Hopital Novo | Pontoise | |
| France | Hopital Novo | Pontoise | |
| France | Centre Hospitalier Bretagne Atlantique | Vannes | |
| France | Groupe Hospitalier Mutualiste Des Portes Du Sud | Venissieux | |
| France | RESEAU DE SANTE MUTUALISTE-Médipôle Hôpital Mutualiste | Villeurbanne | |
| Germany | Diabeteszentrum-Do Dres. K U. Ch. Busch GbR | Dortmund | |
| Germany | Medizinische Klinik III Studienzentrum für Stoffwechselerkrankungen der TU Dresden | Dresden | |
| Germany | Zentrum fuer klinische Studien Suedbrandenburg GmbH | Elsterwerda | |
| Germany | InnoDiab Forschung GmbH | Essen | |
| Germany | MVZ CCB Frankfurt Und Main-Taunus GbR | Frankfurt | |
| Germany | Diabetes-Zentrum Wilhelmsburg | Hamburg | |
| Germany | Diabetes-Zentrum-Wilhelmsburg GbR | Hamburg | |
| Germany | Wendisch/Dahl Hamburg | Hamburg | |
| Germany | Uniklinik Heidelberg Innere Medizin I | Heidelberg | |
| Germany | AmBeNet GmbH | Leipzig | |
| Germany | University of Leipzig | Leipzig | |
| Germany | Diabeteszentrum Ludwigsburg | Ludwigsburg | |
| Germany | Institut für Diabetesforschung GmbH Münster - Dr. med. Rose | Münster | |
| Germany | Institut für Diabetesforschung GmbH Münster - Dr. med. Rose | Münster | |
| Germany | Uniklinik Münster, Klinik für Kardiologie I | Münster | |
| Germany | Uniklinik Münster, Klinik für Kardiologie I | Münster | |
| Germany | RED-Institut für medizinische Forschung und Fortbildung GmbH | Oldenburg in Holstein | |
| Germany | Zentrum für klinische Studien Alexander Segner | Saint Ingbert-Oberwürzbach | |
| Germany | Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann | Witten | |
| India | CIMS- Care Institute of Medical Sciences | Ahmedabad | Gujarat |
| India | CIMS- Care Institute of Medical Sciences | Ahmedabad | Gujarat |
| India | Jawahar Lal Nehru Govt. Medical College | Ajmer | Rajasthan |
| India | Jawahar Lal Nehru Govt. Medical College | Ajmer | Rajasthan |
| India | J N Medical College | Aligarh | |
| India | All India Institute of Medical Sciences_Delhi | Ansari Nagar | New Delhi |
| India | All India Institute of Medical Sciences_Delhi | Ansari Nagar | New Delhi |
| India | Kamalnayan Bajaj Hospital | Aurangabad | Maharashtra |
| India | Kamalnayan Bajaj Hospital | Aurangabad | Maharashtra |
| India | Lifecare Hospital and Research Centre | Bangalore | Karnataka |
| India | Lifecare Hospital and Research Centre | Bangalore | Karnataka |
| India | Narayana Hrudayalya Institute of Cardiac Sciences | Bangalore | |
| India | Narayana Hrudayalya Institute of Cardiac Sciences | Bangalore | |
| India | Ramaiah Memorial Hospital | Bangalore | Karnataka |
| India | AMRI Hospital | Bhubaneswar | Orissa |
| India | SP Medical College | Bikaner | Rajasthan |
| India | Madras Diabetes Research Foundation | Chennai | Tamil Nadu |
| India | Kg Hospital and Post Graduate Medical Institute | Coimbatore | Tamil Nadu |
| India | Kg Hospital and Post Graduate Medical Institute | Coimbatore | Tamil Nadu |
| India | Shri Mahant Indiresh Hospital | Dehradun | Uttarakhand |
| India | Shri Mahant Indiresh Hospital | Dehradun | Uttarakhand |
| India | Apollo Hospital | Delhi | New Delhi |
| India | Indraprastha Apollo Hospital | Delhi | New Delhi |
| India | Endolife Specialty Hospitals | Guntur | Andhra Pradesh |
| India | Lalitha Super Specialities Hospital | Guntur | Andhra Pradesh |
| India | Excelcare Hospital | Guwahati | Assam |
| India | Excelcare Hospital | Guwahati | Assam |
| India | AIG Hospitals,Hyderabad | Hyderabad | Telangana |
| India | Guru Nanak CARE Hospitals | Hyderabad | Telangana |
| India | Ramdev Rao Hospital | Hyderabad | Telangana |
| India | Ramdev Rao Hospital | Hyderabad | Andhra Pradesh |
| India | Mohak Bariatrics and Robotics | Indore | Madhya Pradesh |
| India | Mohak Bariatrics and Robotics | Indore | Madhya Pradesh |
| India | Diabetes, Thyroid and Endocrine Centre | Jaipur | Rajasthan |
| India | Diabetes, Thyroid and Endocrine Centre | Jaipur | Rajasthan |
| India | SMS Medical College & Attached Hospitals | Jaipur | Rajasthan |
| India | All India Institute of Medical Sciences (AIIMS) | Jodhpur | Rajasthan |
| India | All India Institute of Medical Sciences (AIIMS) | Jodhpur | Rajasthan |
| India | All India Institute of Medical Sciences (AIIMS) | Jodhpur | |
| India | All India Institute of Medical Sciences_Khurda | Khurda | Orissa |
| India | Excel Endocrine Centre | Kolhapur | Maharashtra |
| India | Apollo Multispeciality Hospital, Kolkata | Kolkata | West Bengal |
| India | Apollo Multispeciality Hospital, Kolkata | Kolkata | West Bengal |
| India | IPGME&R and SSKM Hospital | Kolkata | West Bengal |
| India | IPGME&R and SSKM Hospital | Kolkata | West Bengal |
| India | Government Medical College, Kozhikode | Kozhikode | Kerala |
| India | King George's Medical University | Lucknow | Uttar Pradesh |
| India | King George's Medical University (KGMU) | Lucknow | Uttar Pradesh |
| India | Sanjay Gandhi Postgraduate Institute of Medical Science | Lucknow | Uttar Pradesh |
| India | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Lucknow | Uttar Pradesh |
| India | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Lucknow | Uttar Pradesh |
| India | Christian Medical College and Hospital | Ludhiana | Punjab |
| India | Christian Medical College and Hospital | Ludhiana | Punjab |
| India | Omega Hospital (P) Limited | Mangalore | Karnataka |
| India | Omega Hospital (P) Limited | Mangalore | Karnataka |
| India | Fortis Heart Institute and Multispeciality Hospital | Mohali | Punjab |
| India | Fortis Heart Institute and Multispeciality Hospital | Mohali | Punjab |
| India | Seth GS Medical College & KEM Hospital | Mumbai | Maharashtra |
| India | Sir H. N. Reliance Foundation Hospital and Research Centre | Mumbai | Maharashtra |
| India | Sir H. N. Reliance Foundation Hospital and Research Centre | Mumbai | Maharashtra |
| India | Wockhardt Hospital, Mumbai Central | Mumbai | Maharashtra |
| India | Mysore Medical College and Research Institute | Mysore | Karnataka |
| India | Mysore Medical College and Research Institute | Mysore | Karnataka |
| India | All India Institute of Medical Sciences (AIIMS), Nagpur | Nagpur | Maharashtra |
| India | All India Institute of Medical Sciences (AIIMS), Nagpur | Nagpur | Maharashtra |
| India | Diabetes Care N' Research Centre Pvt. Ltd. | Nagpur | |
| India | Magnum Heart Institute | Nashik | |
| India | Magnum Heart Institute | Nashik | |
| India | BL Kapur Super Specialty Hospital | New Delhi | |
| India | Dr. BL Kapur Memorial Hospital | New Delhi | |
| India | G.B Pant Institute of Post Graduate medical education and research | New Delhi | |
| India | G.B Pant Institute of Post Graduate medical education and research | New Delhi | |
| India | Sir Ganga Ram Hospital | New Delhi | |
| India | Sir Ganga Ram Hospital | New Delhi | |
| India | Sir Ganga Ram Hospital | New Delhi | |
| India | B J Medical College & Sassoon Hospital | Pune | |
| India | Chellaram Diabetes Institute | Pune | Maharashtra |
| India | Grant Medical Foundation Ruby Hall Clinic | Pune | Maharashtra |
| India | Nirmal Hospital Pvt. Ltd. | Surat | |
| India | Unicare heart institute and research centre | Surat | Gujarat |
| India | Unicare heart institute and research centre | Surat | Gujarat |
| India | Ashirwad Hospital and Research Centre | Thane | Maharashtra |
| India | Rhythm Heart Institute | Vadodara | Gujarat |
| India | Rhythm Heart Institute | Vadodara | Gujarat |
| India | Christian Medical College Hospital, Vellore | Vellore | Tamil Nadu |
| India | Sunrise Hospital | Vijayawada | Andhra Pradesh |
| India | Sunrise Hospital | Vijayawada | Andhra Pradesh |
| Ireland | Clinical Research Centre, St. Vincent's University Hospital, | Dublin | Leinster |
| Ireland | Connolly Hospital | Dublin | Leinster |
| Ireland | Mater Miscericordiae Hospital | Dublin | Leinster |
| Ireland | Mater Miscericordiae Hospital | Dublin | Leinster |
| Ireland | St James's CRF | Dublin | Leinster |
| Ireland | CRF - Galway | Galway | Connaght |
| Ireland | CRF - Galway | Galway | Connaght |
| Italy | Ente Ecclesiastico Ospedale Generale Regionale Miulli | Acquaviva delle Fonti | |
| Italy | Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona | Ancona | |
| Italy | A.O.U. Consorziale Policlinico di Bari | Bari | BA |
| Italy | A.O.U. Policlinico S.Orsola Malpighi | Bologna | |
| Italy | A.O.U policlinico "G. Rodolico-San Marco" | Catania | |
| Italy | Università degli studi G. D'Annunzio Chieti Pescara - CAST | Chieti Scalo | |
| Italy | AOU Careggi Firenze | Firenze | |
| Italy | Ospedale Santa Maria Goretti - UOD Diabetologia | Latina | LT |
| Italy | Azienda Ospedaliera Luigi Sacco | Milano | |
| Italy | Azienda Ulss 3 Serenissima | Mirano | VE |
| Italy | Azienda Ospedaliero Universitaria di Modena Ospedale Civile di Baggiovara | Modena | |
| Italy | Azienda Ospedaliera Universitaria Federico II di Napoli | Napoli | |
| Italy | AOUP Giaccone Palermo | Palermo | |
| Italy | Azienda Ospedaliera-Universitaria Parma | Parma | |
| Italy | ICS Maugeri | Pavia | Pv |
| Italy | Azienda Ospedaliero Universitaria Pisana | Pisa | |
| Italy | Azienda Ospedaliero - Universitaria Sant'Andrea | Roma | |
| Italy | Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia | Roma | |
| Italy | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Rome | RM |
| Italy | Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab | San Donato Milanese (MI) | MI |
| Italy | IRCCS Multimedica | Sesto San Giovanni (MI) | |
| Italy | Azienda Ospedaliera Universitaria Senese | Siena | Si |
| Japan | Akaicho Clinic | Chiba-shi, Chiba | |
| Japan | Mikannohana Clinic, Diabetes, Endocrinology and Metabolism_Diabetes Internal Medicine | Ehime | |
| Japan | Naka Kinen Clinic | Ibaraki | |
| Japan | Seino Internal Medicine Clinic | Koriyama-shi | Fukushima, Japan |
| Japan | Jinnouchi Hospital | Kumamoto-shi | Kumamoto, Japan |
| Japan | Tokyo Saiseikai Central Hospital | Minato-ku, Tokyo | |
| Japan | Minami Akatsuka Clinic | Mito-shi, Ibaraki | |
| Japan | Nanbu Tokushukai Hospital_Internal medicine | Okinawa | |
| Japan | AMC NISHI-UMEDA Clinic | Osaka | |
| Japan | Nozaki Tokushukai Hospital | Osaka | |
| Japan | Yao Tokushukai General Hospital | Osaka | |
| Japan | Sakurabashi Watanabe Advanced Healthcare Hospital | Osaka-city, Osaka | |
| Japan | Saga University Hospital, Department of Cardiology | Saga | |
| Japan | Kagawa Prefectural Central Hospital, Cardiovascular Medicine | Takamatsu-shi, Kagawa | |
| Japan | Takasaki General Medical Center_Department of Endocrinology / Metabolism Internal Medicine | Takasaki-shi, Gunma | |
| Japan | Fukuwa Clinic | Tokyo | |
| Japan | Tokyo-Eki Center-building Clinic | Tokyo | |
| Japan | Tokyo-Eki Center-building Clinic | Tokyo | |
| Japan | Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology | Wakayama | |
| Japan | National Hospital Organization Saitama Hospital | Wako-shi, Saitama | |
| Malaysia | Hospital Pulau Pinang | George Town | Penang |
| Malaysia | Hospital Serdang | Kajang | Selangor |
| Malaysia | University Malaya Medical Centre | Kuala Lumpur | Wilayah Persekutuan Kuala Lumpur |
| Malaysia | Sarawak General Hospital | Kuching | |
| Malaysia | Hospital Melaka | Melaka | |
| Malaysia | Hospital Miri | Sarawak | |
| Malaysia | Hospital Seri Manjung | Seri Manjung | Perak |
| Malaysia | Hospital Shah Alam | Shah Alam | |
| Malaysia | Hospital Sibu | Sibu | Sarawak |
| Malaysia | Hospital Sultan Haji Ahmad Shah | Temerloh,Pahang | |
| Mexico | Promotora Medica Aguascalientes SA de CV | Aguascalientes | |
| Mexico | Centro de Estudios de Investigación Metabólicos y Cardio | Ciudad Madero | Tamaulipas |
| Mexico | Instituto de Diabetes Obesidad y Nutricion S.C. | Cuernavaca | Morelos |
| Mexico | Centro de Investigacion Clinica Endocrinologica de Jalisco | Guadalajara | Jalisco |
| Mexico | Virgen Cardiovascular Research SC | Guadalajara | Jalisco |
| Mexico | Clínica García Flores | Monterrey | Nuevo León |
| Mexico | Internal Medicine Clin Trials | Monterrey | Nuevo León |
| Mexico | Unidad Biomedica Avanzada Monterrey | Monterrey | Nuevo León |
| Mexico | Centro de atención e investigación cardiovascular del Potosí | San Luis Potosí | San Luis Potosi |
| Mexico | Consultorio 1020 Hospital Angeles Xalapa | Xalapa | Veracruz |
| Netherlands | Gelre Ziekenhuizen Apeldoorn | Apeldoorn | |
| Netherlands | Máxima Medisch Centrum | Eindhoven | |
| Netherlands | Groene Hart Ziekenhuis, locatie Bleuland | Gouda | |
| Netherlands | UMC Groningen | Groningen | |
| Netherlands | Medisch Centrum Leeuwarden | Leeuwarden | |
| Netherlands | Radboudumc | Nijmegen | |
| Netherlands | Franciscus Gasthuis en Vlietland | Rotterdam | |
| Netherlands | D & A Research B.V. | Sneek | |
| Netherlands | Ziekenhuis Rivierenland Tiel | Tiel | |
| Poland | American Heart of Poland S.A. | Belchatow | Lodzkie |
| Poland | Gabinet Leczenia Otylosci i Chorob Dietozaleznych | Bialystok | Podlaskie Voivodeship |
| Poland | Kresmed Sp. z o. o. | Bialystok | Podlaskie |
| Poland | Osteo-Medic s.c. A. Racewicz, J. Supronik | Bialystok | |
| Poland | Renew Clinic Bialystok | Bialystok | |
| Poland | Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio | Bialystok | Podlaskie |
| Poland | American Heart of Poland S.A. | Bielsko-Biala | |
| Poland | Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j. | Bydgoszcz | |
| Poland | Gierach-Med | Bygdoszcz | |
| Poland | Gierach-Med | Bygdoszcz | Kuyavian-Pomeranian Voivodeship |
| Poland | Pratia S.A. | Chojnice | |
| Poland | Pratia S.A. | Chojnice | |
| Poland | Malopolskie Centrum Sercowo-Naczyniowe | Chrzanow | Malopolskie |
| Poland | NSZOZ Unica CR | Dabrowka | |
| Poland | NSZOZ Unica CR | Dabrowka | Wielkopolskie |
| Poland | Centrum Kliniczno Badawcze | Elblag | |
| Poland | UCK Klinika Nadcisnienia Tetniczego i Diabetologii | Gdansk | |
| Poland | Centrum Medyczne Pratia Gdynia | Gdynia | Pomorskie |
| Poland | Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski | Gorzow Wielkopolski | Lubuskie |
| Poland | Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski | Gorzow Wielkopolski | |
| Poland | CareClinic | Katowice | |
| Poland | Kardio Klinika Brynów | Katowice | Silesia |
| Poland | M2M Med. Sp. z o.o. Sp. j. | Katowice | |
| Poland | Pro Familia Altera Sp. z o.o. | Katowice | Slaskie |
| Poland | Uniwersyteckie Centrum Kliniczne SUM w Katowicach | Katowice | |
| Poland | Grazyna Pulka Specjalistyczny Osrodek "All-Med" | Krakow | |
| Poland | Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET | Krakow | Malopolskie |
| Poland | Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi | Lodz | |
| Poland | Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi | Lodz | |
| Poland | Gabinet Lekarski Malgorzata Saryusz-Wolska | Lodz | |
| Poland | Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika | Lodz | Lodzkie |
| Poland | Velocity Nova Sp. z o.o. | Lublin | Lublin Voivodeship |
| Poland | Zanamed Medical Clinic Sp. z o.o. | Lublin | |
| Poland | Provita Centrum Medyczne Sp. z o.o. | Piotrkow Trybunalski | |
| Poland | Provita Centrum Medyczne Sp. z o.o. | Piotrkow Trybunalski | |
| Poland | ETG Poniatowa | Poniatowa | Lublin Province |
| Poland | Centrum Zdrowia Metabolicznego | Poznan | Wielkopolskie Voivodeship |
| Poland | Gaja Poradnie Lekarskie | Poznan | |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j. | Ruda Slaska | |
| Poland | Velocity Nova Sp. z o.o. | Staszow | |
| Poland | Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach | Tychy | |
| Poland | ETG Warszawa | Warsaw | Masovian |
| Poland | MEDI CLINICAL Badania Kliniczne | Warsaw | Masovian Province |
| Poland | Provita Poliklinika Sp. z o.o | Warsaw | Masovian Province |
| Poland | Provita Poliklinika Sp. z o.o | Warsaw | Masovian Province |
| Poland | BodyClinic | Warszawa | |
| Poland | NASMED | Warszawa | |
| Poland | NASMED | Warszawa | |
| Poland | Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego | Warszawa | Mazowieckie |
| Poland | Szpital Czerniakowski Sp. z o.o. | Warszawa | |
| Poland | 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu | Wroclaw | Dolnoslaskie |
| Poland | Pracownia Badan Klinicznych SALUS | Wroclaw | |
| Poland | Pracownia Badan Klinicznych SALUS | Wroclaw | |
| Poland | Regionalna Poradnia Diabetologiczna-Zytkiewicz-Jaruga, Stasinska Spólka Partnerska Lekarzy | Wroclaw | Lower Silesian Province |
| Poland | Slaskie Centrum Chorob Serca W Zabrzu | Zabrze | Slaskie |
| Poland | Slaskie Centrum Chorob Serca W Zabrzu | Zabrze | Slaskie |
| Poland | Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu | Zabrze | |
| Poland | Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu | Zabrze | Slaskie |
| Poland | Velocity Zamosc | Zamosc | |
| Poland | Prywatna Praktyka Lekarska Anna Chudoba | Zyrardów | Masovian |
| Serbia | CHC Zvezdara, Clinical department for endocrinology | Belgrade | |
| Serbia | Clinical Hospital Center Bezanijska Kosa | Belgrade | |
| Serbia | Clinical Hospital Center Bezanijska Kosa | Belgrade | |
| Serbia | Endocrinology, Diabetes and Metabolism Diseases Clinic | Belgrade | |
| Serbia | Endocrinology, Diabetes and Metabolism Diseases Clinic | Belgrade | |
| Serbia | Military Medical Academy | Belgrade | |
| Serbia | Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department | Kragujevac | |
| Serbia | Clinical Centre Nis, Endocrinology, Diabetes and Metabolism | Nis | RS |
| Serbia | University Clinical Centre Nis | Nis | RS |
| Serbia | University Clinical Centre Nis | Nis | RS |
| Serbia | Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis. | Novi Sad | Vojvodina |
| Serbia | Policlinic for diabetes | Zajecar | |
| South Africa | Cardiac Clinical Research Unit, University of Cape Town | Cape Town | Western Cape |
| South Africa | Prof Rayner | Cape Town | Western Cape |
| South Africa | Tread Research (Pty)Ltd | Cape Town | Western Cape |
| South Africa | Dr A Amod | Durban | KwaZulu-Natal |
| South Africa | Dr Pillay's Rooms | Durban | KwaZulu-Natal |
| South Africa | Maxwell Centre | Durban | KwaZulu-Natal |
| South Africa | Netcare Umhlanga Medical Centre | Durban | KwaZulu-Natal |
| South Africa | Ezintsha Research Centre | Johannesburg | Gauteng |
| South Africa | Hemant Makan | Johannesburg | Gauteng |
| South Africa | Soweto Clinical Trial Centre | Johannesburg | Gauteng |
| South Africa | Dr Hendrik Snyman's Practice | Mossel Bay | Western Cape |
| South Africa | Phoenix Pharma | Port Elizabeth | Eastern Cape |
| South Africa | Clinical Trial Systems (CTC) | Pretoria | Gauteng |
| South Africa | Dr Seeber | Pretoria | Gauteng |
| South Africa | Jongaie Research | Pretoria | Gauteng |
| South Africa | Prinshof Medical Campus | Pretoria | Gauteng |
| South Africa | Prof P. Joshi | Pretoria | Gauteng |
| South Africa | Raslouw Private Hospital | Pretoria | Gauteng |
| South Africa | Clinical Projects Research | Worcester | Western Cape |
| Spain | Hospital de la Ribera | Alzira | Valencia |
| Spain | Hospital Comarcal de Antequera | Antequera | |
| Spain | Hospital Vall d'Hebron | Barcelona | |
| Spain | Hospital Vithas Sevilla | Castilleja Dela Cuesta Sevilla | |
| Spain | Hospital Reina Sofia | Córdoba | |
| Spain | Hospital Universitario de Fuenlabrada | Fuenlabrada | Madrid |
| Spain | Hospital Universitario de Gran Canaria Doctor Negrín | Las Palmas de Gran Canaria | |
| Spain | Hospital Gregorio Marañón | Madrid | |
| Spain | Hospital Clínico Virgen de la Victoria | Málaga | |
| Spain | Hospital Son Espases | Palma de Mallorca | |
| Spain | Hospital Quirón | Pozuelo de Alarcón | |
| Spain | Hospital Virgen del Camino - Sanlúcar de Barrameda | Sanlúcar de Barrameda | |
| Spain | Clínica Nuevas Tecnologías en Diabetes y Endocrinología | Sevilla | |
| Spain | Hospital Universitario Virgen del Rocío | Sevilla | |
| Spain | Hospital General Universitario de Toledo | Toledo | |
| Spain | Hospital General de Valencia | Valencia | |
| Thailand | Cardio-Vajira | Bangkok | |
| Thailand | King Chulalongkorn Memorial Hospital | Bangkok | |
| Thailand | Phramongkutklao Hospital | Bangkok | |
| Thailand | Phramongkutklao Hospital-neuro | Bangkok | |
| Thailand | Rajavithi Hospital | Bangkok | |
| Thailand | Siriraj Hospital | Bangkok | |
| Thailand | Siriraj Hospital | Bangkok | |
| Thailand | Maharaj Nakorn Chiang Mai Hospital | Chiang Mai | |
| Thailand | Research Institute for Health Sciences, CMU | Chiang Mai | |
| Thailand | Srinagarind Hospital | Khon Kaen | |
| Thailand | Thammasat University Hospital | Klong Luang, Pathumthani | Pathumthani |
| Thailand | Chiang Rai Prachanukroh Hospital | Muang | |
| Thailand | Maharat Nakhon Ratchasima Hospital | Mueang Nakhon Ratchasima | Nakhon Ratchasima |
| Thailand | Ramathibodi Hospital | Rajataewe | Bangkok |
| Thailand | Songklanagarind Hospital | Songkla | |
| Turkey | Baskent Universitesi Adana | Adana | |
| Turkey | T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastan | Adana | |
| Turkey | Afyonkarahisar Health Sciences University | Afyon | |
| Turkey | Ankara Sehir Hastanesi Dahiliye Klinigi | Ankara | |
| Turkey | Baskent University Ankara Hospital | Ankara | Bahcelievler |
| Turkey | Baskent University Ankara Hospital | Ankara | Bahcelievler |
| Turkey | T.C. Saglik Bakanligi Bursa Il Saglik Mudurlugu Yuksek Ihtis | Bursa | Yildirim |
| Turkey | Trakya University | Edirne | |
| Turkey | Eskisehir Osmangazi University Saglik Uygulama ve Arastirma | Eskisehir | Odunpazari |
| Turkey | Eskisehir Sehir Hastanesi | Eskisehir | |
| Turkey | Basaksehir Cam ve Sakura Sehir Hastanesi | Istanbul | |
| Turkey | Istanbul University Cardiology Institute | Istanbul | |
| Turkey | Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi | Istanbul | |
| Turkey | Kartal Kosuyolu Yüksek Ihtisas Egitim ve Arastirma Hastanesi | Istanbul | Kartal |
| Turkey | Marmara University, Endocrinology Department | Istanbul | |
| Turkey | Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi | Istanbul | |
| Turkey | T.C SB Goztepe Prof. Dr. Suleyman Yalcin City Hospital | Istanbul | |
| Turkey | Dokuz Eylul University Medical Faculty | Izmir | |
| Turkey | Kahramanmaras Sutcu Imam University | Kahramanmaras | |
| Turkey | Erciyes Universitesi Tip Fakultesi | Kayseri | |
| Turkey | Erciyes University Cardiology | Kayseri | |
| Turkey | Kocaeli Universitesi Tip Fakultesi Hastanesi | Kocaeli | |
| Turkey | Kutahya Saglik Bilimleri Universitesi | Kutahya | |
| Turkey | Mersin University Cardiology | Mersin | |
| Turkey | Mersin University Cardiology | Mersin | |
| Turkey | Mersin University Medicine Faculty | Mersin | |
| Turkey | Samsun Ondokuz Mayis Universitesi | Samsun | |
| United Kingdom | Blackpool Victoria Hospital | Blackpool | Lancashire |
| United Kingdom | Bradford Royal Infirmary | Bradford | |
| United Kingdom | The Health Centre | Bradford-on-Avon | |
| United Kingdom | Southmead Hospital | Bristol | |
| United Kingdom | Countess of Chester Hospital | Chester | |
| United Kingdom | University Hospitals of Coventry and Warwickshire NHS Trust | Coventry | |
| United Kingdom | Ninewells Hospital | Dundee | |
| United Kingdom | Western General Hospital | Edinburgh | |
| United Kingdom | Royal Devon University Healthcare NHS Foundation Trust | Exeter | |
| United Kingdom | Intelligent Clinical | Glasgow | |
| United Kingdom | Hull Royal Infirmary | Hull | |
| United Kingdom | The Diabetes Centre | Ipswich | |
| United Kingdom | St James's University Hospital | Leeds | |
| United Kingdom | Leicester General Hospital | Leicester | |
| United Kingdom | The Good Practice | London | |
| United Kingdom | Patient Recruitment Centre: Newcastle | Newcastle upon Tyne | |
| United Kingdom | University Dept of Medicine, Derriford Hospital, Plymouth | Plymouth | |
| United Kingdom | East Surrey Hospital | Redhill | |
| United Kingdom | East Surrey Hospital | Redhill | |
| United Kingdom | Clifton Medical Centre | Rotherham | |
| United Kingdom | The Staploe Medical Centre | Soham | |
| United Kingdom | Royal Cornwall Hospital (Treliske) | Truro | |
| United Kingdom | St. Richards Hospital | West Sussex | |
| United States | Albany Medical College | Albany | New York |
| United States | Renal Medicine Associates | Albuquerque | New Mexico |
| United States | PharmaTex Research | Amarillo | Texas |
| United States | Arlington Family Res. Ctr Inc | Arlington | Texas |
| United States | Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois |
| United States | Ascension Saint Agnes Heart Ca | Baltimore | Maryland |
| United States | Heritage Valley Medical Group | Beaver | Pennsylvania |
| United States | National Heart Institute Cal | Beverly Hills | California |
| United States | Univ of Alabama Birmingham | Birmingham | Alabama |
| United States | Bridgeport Hospital | Bridgeport | Connecticut |
| United States | UNC- Chapel Hill | Chapel Hill | North Carolina |
| United States | Univ Diab & Endo Consultants | Chattanooga | Tennessee |
| United States | Innovative Research of W Florida Inc. | Clearwater | Florida |
| United States | Cleveland Clinic - Main Campus | Cleveland | Ohio |
| United States | South Texas Clinical Research | Corpus Christi | Texas |
| United States | West Broadway Clinic | Council Bluffs | Iowa |
| United States | Valley Clinical Trials | Covina | California |
| United States | Baylor Scott & White Res Inst | Dallas | Texas |
| United States | Velocity Clinical Res-Dallas | Dallas | Texas |
| United States | Providence Health Partners Ctr | Dayton | Ohio |
| United States | Florida Premier Cardiology | Delray Beach | Florida |
| United States | Dallas Heart and Vascular | Duncanville | Texas |
| United States | Duke University | Durham | North Carolina |
| United States | Academy of Diabetes, Thyroid & Endocrine, P.A. | El Paso | Texas |
| United States | Lillestol Research LLC | Fargo | North Dakota |
| United States | Fleming Island Center for Clinical Research | Fleming Island | Florida |
| United States | Elite Research Center | Flint | Michigan |
| United States | Diabetes and Thyroid Ctr of FW | Fort Worth | Texas |
| United States | American Hlth Ntwk of IN LLC | Franklin | Indiana |
| United States | Macoupin Research Group | Gillespie | Illinois |
| United States | Clinical Invest Special_Gurnee | Gurnee | Illinois |
| United States | Louisiana Heart Center | Hammond | Louisiana |
| United States | PrimeCare Medical Group | Houston | Texas |
| United States | Southwest Houston Research Ltd | Houston | Texas |
| United States | Synergy Groups Medical | Houston | Texas |
| United States | Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho |
| United States | Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho |
| United States | Clinical Research Consultants, LLC | Kansas City | Missouri |
| United States | Prem Internal Med Asso Houston | Katy | Texas |
| United States | Scripps Wht Diab Inst La Jolla | La Jolla | California |
| United States | Radiance Clinical Research | Lampasas | Texas |
| United States | First Valley Medical Group | Lancaster | California |
| United States | The Research Group of Lexington LLC | Lexington | Kentucky |
| United States | Clinical Trials Research_Sacramento | Lincoln | California |
| United States | Clinical Trials Research_Sacramento | Lincoln | California |
| United States | Torrance Clin Res Inst, Inc. | Lomita | California |
| United States | DCOL Ctr for Clin Res | Longview | Texas |
| United States | Pacific Clinical Studies | Los Alamitos | California |
| United States | L-MARC Research Center | Louisville | Kentucky |
| United States | L-MARC Research Center | Louisville | Kentucky |
| United States | Texas Inst, Kdny & Endo Disor | Lufkin | Texas |
| United States | Ohio- Advanced Medical Research | Maumee | Ohio |
| United States | Texas Institute of Cardiology PA | McKinney | Texas |
| United States | Life Spring Research | Miami | Florida |
| United States | Oceane 7 Medical & Research Center, Inc. | Miami | Florida |
| United States | Reyes Clinical Research, Inc | Miami | Florida |
| United States | Floridian Clinical Research, LLC | Miami Lakes | Florida |
| United States | San Marcus Res Clin Miami Lakes | Miami Lakes | Florida |
| United States | Monterey Endocrine & Diabetes Institute, Inc | Monterey | California |
| United States | Chambliss Clinical Trials LLC | Montgomery | Alabama |
| United States | Carteret Medical Group | Morehead City | North Carolina |
| United States | Adult Medicine of Lake County, Inc. | Mount Dora | Florida |
| United States | Carolina Health Specialists | Myrtle Beach | South Carolina |
| United States | Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire |
| United States | Eastern Nephr Assoc, PLLC | New Bern | North Carolina |
| United States | Tulane University Health Sciences Center | New Orleans | Louisiana |
| United States | Suncoast Clinical Research, Inc. | New Port Richey | Florida |
| United States | Capital Area Research LLC | Newport | Pennsylvania |
| United States | York Clinical Research LLC | Norfolk | Virginia |
| United States | Valley Clinical Trials, Inc. | Northridge | California |
| United States | Methodist Physicians Clin | Omaha | Nebraska |
| United States | Univ of NE Med Center_Omaha | Omaha | Nebraska |
| United States | VA Neb West Iowa Hlth System | Omaha | Nebraska |
| United States | Midwest Heart & Vasc Spec | Overland Park | Kansas |
| United States | Desert Oasis Hlthcr Med Group | Palm Springs | California |
| United States | Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania |
| United States | Western University of Health Sciences | Pomona | California |
| United States | Western University of Health Sciences | Pomona | California |
| United States | Hanson Clinical Research Center | Port Charlotte | Florida |
| United States | Dominion Medical Associates | Richmond | Virginia |
| United States | Endo Res Solutions Inc | Roswell | Georgia |
| United States | Texas Diabetes & Endocrinology_Round Rock | Round Rock | Texas |
| United States | Northeast Research Institute | Saint Augustine | Florida |
| United States | Northeast Research Institute | Saint Augustine | Florida |
| United States | Amicis Centers of Clinical Research | Saint Louis | Missouri |
| United States | St Louis Heart & Vascular, P.C. | Saint Louis | Missouri |
| United States | StudyMetrix Research LLC | Saint Peters | Missouri |
| United States | VA Medical Center_Salem | Salem | Virginia |
| United States | Audie L. Murphy VA Hospital | San Antonio | Texas |
| United States | Clinical Advancement Ctr, PLLC | San Antonio | Texas |
| United States | Northeast Clinical Research of San Antonio | San Antonio | Texas |
| United States | San Antonio Prem Int Med | San Antonio | Texas |
| United States | Univ Of Texas Hlth Science Cntr | San Antonio | Texas |
| United States | Linda Vista Health Care Ctr | San Diego | California |
| United States | N America Res Inst - San Dimas | San Dimas | California |
| United States | Saratoga Clinical Research | Saratoga Springs | New York |
| United States | Honor Health | Scottsdale | Arizona |
| United States | NorthShore Univ Hlth Sys | Skokie | Illinois |
| United States | Clinvest Research | Springfield | Missouri |
| United States | Piedmont Healthcare/Research | Statesville | North Carolina |
| United States | Simcare Medical Research, LLC | Sugar Land | Texas |
| United States | Lundquist Inst.-Biom Inno-UCLA | Torrance | California |
| United States | Arcturus Healthcare, PLC | Troy | Michigan |
| United States | Hillcrest Family Health Center | Waco | Texas |
| United States | Aspirus Research Institute | Wausau | Wisconsin |
| United States | Cardio Partners Clin Res Inst | Wellington | Florida |
| United States | Confluence Health Hospital | Wenatchee | Washington |
| United States | Valley Diab. & Endo Comp Ctr | Weslaco | Texas |
| United States | Iowa Diab & Endo Res Center | West Des Moines | Iowa |
| United States | Clinical Trials Of America | West Monroe | Louisiana |
| United States | Southgate Medical Group, LLP | West Seneca | New York |
| United States | Great Lakes Medical Research | Westfield | New York |
| United States | Selma Medical Associates | Winchester | Virginia |
| United States | Brookview Hills Research Associates, LLC | Winston-Salem | North Carolina |
| Lead Sponsor | Collaborator |
|---|---|
| Novo Nordisk A/S |
United States, Argentina, Australia, Brazil, Bulgaria, Canada, Colombia, Denmark, France, Germany, India, Ireland, Italy, Japan, Malaysia, Mexico, Netherlands, Poland, Serbia, South Africa, Spain, Thailand, Turkey, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Time to first occurrence of major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to occurrence of CV death | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of a composite heart failure endpoint consisting of: CV death, heart failure, hospitalisation and urgent heart failure visit | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of a composite endpoint: Onset of persistent =40% reduction in eGFRcr (CKD-EPI), Onset of persistent eGFRcr (CKD-EPI) <15 mL/min/1.73 m2, Initiation of chronic kidney replacement therapy, Kidney death and CV death | CKD-EPI is Chronic Kidney Disease Epidemiology Collaboration. Measured in days. | From baseline (week -3) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of all-cause death | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of an expanded MACE composite endpoint consisting of: CV death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation and unstable angina requiring hospitalisation | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of a composite endpoint consisting of: all-cause death, non-fatal myocardial infarction and non-fatal stroke | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of myocardial infarction (fatal and non-fatal) | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Time to first occurrence of stroke (fatal and non-fatal) | Measured in days. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Relative change in body weight | Measured in percentage (%). | From baseline (week 0) to 120 weeks | |
| Secondary | Change in waist circumference | Measured in centimeters (cm). | From baseline (week 0) to 120 weeks | |
| Secondary | Change in systolic blood pressure (SBP) | Measured in millimeters of mercury (mmHg). | From baseline (week 0) to 120 weeks | |
| Secondary | Change in diastolic blood pressure (DBP) | Measured in mmHg. | From baseline (week 0) to 120 weeks | |
| Secondary | Relative change in lipids: Total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, triglycerides and free fatty acids | Measured in percentage. | From baseline (week 0) to 120 weeks | |
| Secondary | Change in glycated haemoglobin (HbA1c) | Measured in percentage-points. | From baseline (week 0) to 120 weeks | |
| Secondary | Change in Short Form 36 v2.0 acute (SF-36v2) | SF-36v2.0 is a 36-item commonly used generic clinical outcome assessment (COA) instrument measuring health-related quality of life and general health status across disease areas. The SF-36v2.0 for adults with a 1 week recall period (i.e. acute version) measures the individual overall health-related quality of life in 8 health domains (physical functioning, role-physical, bodily pain, general health, social functioning, role emotional, vitality and mental health). Furthermore, it includes two aggregated scores: a physical component summary score and a mental component summary score. Range of score for domains and component summary scores : 1-100 (Higher scores indicated a better health state). | From baseline (week 0) to 120 weeks | |
| Secondary | Number of treatment emergent serious adverse events (TESAEs) | Measured in count of events. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Number of event adjudication committee (EAC)-confirmed malignant neoplasms | Measured as count of events. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Number of severe hypoglycaemic episodes (level 3) (only for participants with type 2 diabetes mellitus [T2D] at screening) | Measured as count of events. | From baseline (week 0) to end of study (up to 242 weeks or more) | |
| Secondary | Change from baseline in high-sensitivity C-reactive protein (hsCRP) | Measured in milligram per liter (mg/L) | From baseline (week 0) to 120 weeks | |
| Secondary | Change from baseline in tumour necrosis factor alpha (TNF-a) | Measured in picograms per milliliter (pg/mL) | From baseline (week 0) to 120 weeks | |
| Secondary | Change from baseline in Interleukin 6 (IL-6) | Measured in pg/mL. | From baseline (week 0) to 120 weeks | |
| Secondary | Change from baseline in Interleukin 1 beta (IL-1ß) | Measured in pg/mL. | From baseline (week 0) to 120 weeks | |
| Secondary | Change in pain intensity rated by Numerical Rating Scale (NRS) | The NRS rates average pain intensity in the last 24 hours on a scale from 0 to 10, with 0 meaning 'No pain' and '10' meaning 'Pain as bad as you can imagine'. | From baseline (week 0) to 120 weeks | |
| Secondary | Change in Pittsburgh Sleep Quality Index (PSQI) | The Pittsburgh Sleep Quality Index is a 19-item, self-rated questionnaire, assessed various aspects of sleep, sleep quality, and sleep disturbances. The PSQI is composed of 7 components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The sum of scores for these 7 components yields 1 global score. An overall score ranges from 0 to 21, where lower scores denote a healthier sleep quality. | From baseline (week 0) to 120 weeks | |
| Secondary | Change in neuropathy status by baseline neuropathy group (painful neuropathy, painless neuropathy or no neuropathy) | Measured in percentage. | From baseline (week 0) to 120 weeks |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02122198 -
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
|
N/A | |
| Completed |
NCT02502812 -
Bioequivalence Study of Clopidogrel 75 mg in Two Tablet Formulations Relative to Reference Tablet in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT04216342 -
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT03654313 -
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
|
Phase 1 | |
| Completed |
NCT03646656 -
Heart Health Buddies: Peer Support to Decrease CVD Risk
|
N/A | |
| Completed |
NCT02081066 -
Identification of CETP as a Marker of Atherosclerosis
|
N/A | |
| Completed |
NCT02147626 -
Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia
|
N/A | |
| Not yet recruiting |
NCT06405880 -
Pharmacist Case Finding and Intervention for Vascular Prevention Trial
|
N/A | |
| Recruiting |
NCT03095261 -
Incentives in Cardiac Rehabilitation
|
N/A | |
| Completed |
NCT02868710 -
Individual Variability to Aerobic Exercise Training
|
N/A | |
| Completed |
NCT02589769 -
Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons
|
N/A | |
| Completed |
NCT02711878 -
Healing Hearts and Mending Minds in Older Adults Living With HIV
|
N/A | |
| Completed |
NCT02998918 -
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
|
N/A | |
| Not yet recruiting |
NCT02578355 -
National Plaque Registry and Database
|
N/A | |
| Recruiting |
NCT02885792 -
Coronary Artery Disease in Patients Suffering From Schizophrenia
|
N/A | |
| Completed |
NCT02272946 -
Effect of IL--1β Inhibition on Inflammation and Cardiovascular Risk
|
Phase 2 | |
| Completed |
NCT02657382 -
Mental Stress Ischemia: Biofeedback Study
|
N/A | |
| Completed |
NCT02640859 -
Investigation of Metabolic Risk in Korean Adults
|
||
| Completed |
NCT02652975 -
Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium
|
N/A | |
| Recruiting |
NCT02265250 -
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
|