Reducing PM-associated CV Health Effects for Seniors

Status Completed

Clinical Trial Summary

The objective of this study is to investigate the effectiveness of air filtration at reducing personal-level exposures to fine particulate matter (PM2.5) and mitigating related cardiovascular (CV) health effects among older adults in a residential facility in a representative US urban location. We enrolled 40 nonsmoking older adults into a randomized double-blind crossover intervention study with daily CV health outcomes and PM2.5 exposure measurements. The study was conducted in a low-income senior living apartment building in downtown Detroit, Michigan. Participants were exposed to three 3-day scenarios separated by one-week washout periods: unfiltered ambient air (control), low-efficiency (LE) "HEPA-type", and high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence. The primary outcome was brachial blood pressure (BP). Secondary outcomes included noninvasive aortic hemodynamics and pulse wave velocity and heart rate variability. PM2.5 exposures were measured in the participants' residences as well as by personal-level monitoring.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03334565
Study type	Interventional
Source	Michigan State University
Contact
Status	Completed
Phase	N/A
Start date	October 21, 2014
Completion date	November 4, 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05380167` - Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion	N/A
Recruiting	`NCT06235658` - Yoga in Older Cardiac Patients	N/A
Completed	`NCT04291690` - The TARGET-EFT Randomized Clinical Trial	N/A
Not yet recruiting	`NCT05536310` - TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease
Completed	`NCT04778891` - The Impact of Comprehensive Medication Management Services on Clinical Outcomes in Patients With Cardiovascular Diseases at Primary Care Level	N/A
Recruiting	`NCT03895541` - Noninvasive Elastography Evaluation of Myocardial Stiffness in Elderly Patients With Isolated Diastolic Heart Failure: New Diagnostic Tool?	N/A
Not yet recruiting	`NCT05617196` - Virtual PREHAB Study for Patients Undergoing TAVI	N/A
Recruiting	`NCT06336070` - Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study	N/A
Completed	`NCT05888506` - Ketone Ester Supplementation and Nocturnal Blood Pressure	N/A