Cardiovascular Disease Clinical Trial
Official title:
Local Haemodynamic Effects of Apelin Agonists and Antagonists in Man in Vivo
Apelins are substances which occur naturally in the body, and have an important role in
heart disease. They have been shown to make blood vessels dilate, and improve the way the
heart works.
The investigators have devised 2 sets of experiments to investigate how the apelins affect
blood vessels.
In the first group of experiments,the investigators will give healthy volunteers up to 3
different apelin substances, and use special research techniques to see how they affect the
way that blood vessels work in the forearm.
In the second group of experiments, the apelins will be given along with another form of
apelin which blocks the effects of apelin in laboratory experiments. The investigators want
to see if it blocks the effects of apelin in healthy humans.
The investigators intend to test the hypothesis that:
Apelin agonists are vasodilators in human resistance vessels, this effect will be blocked by
an apelin receptor antagonist.
This study will help us to understand more about how apelins work, and to suggest how they
might be used to treat heart disease.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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