Cardiovascular Disease Clinical Trial
Official title:
Dyslipidemia-related Variables as Risk Factor for Cardiovascular Disease in Patients on the End-stage of Renal Disease
Verified date | February 2014 |
Source | National and Kapodistrian University of Athens |
Contact | n/a |
Is FDA regulated | No |
Health authority | Greece: Ethics Committee |
Study type | Observational |
In this study, we studied lipoprotein abnormalities-related variables as risk factors for the development of cardiovascular disease in patients on renal replacement therapies.We studied 96 dialyzed patients, 62 males and 34 females, on mean age 62.1 years old and 24 healthy controls.We concluded that metabolic acidosis activating the inflammation and lipoprotein oxidation influences the dyslipidemia and cardiovascular morbidity of patients on renal replacement therapies.Dialysis adequacy was positively associated to cardioprotective HDL.Peritoneal dialysis holds a better acidosis level and lower oxidized lipids than hemodialysis modalities.
Status | Completed |
Enrollment | 96 |
Est. completion date | January 2014 |
Est. primary completion date | January 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 24 Years to 87 Years |
Eligibility |
Inclusion Criteria: - permanent renal replacement therapy more than 6 months and - accurate dry body weight Exclusion Criteria: - acute illness, - significant infection, - malignancy, - Kt/V for urea <1.2. |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
National and Kapodistrian University of Athens |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Associations between dyslipidemia with cardiovascular disease on patients on renal replacement therapy | February 2014 | No |
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