Cardiovascular Disease Clinical Trial
— SPIRE-2Official title:
Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects
| Verified date | April 2019 |
| Source | Pfizer |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).
| Status | Terminated |
| Enrollment | 10564 |
| Est. completion date | April 3, 2017 |
| Est. primary completion date | April 3, 2017 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Must be on background lipid lowering treatment. - Must be at high risk of a CV event. - Must have an LDL C >/=100 mg/dL (2.6 mmol/L) OR non HDL C >/=130 mg/dL (3.4 mmol/L). Exclusion Criteria: - Planned coronary (PCI or CABG) or other arterial revascularization. - New York Heart Association Class IV congestive heart failure or left ventricular ejection fraction < 25% by cardiac imaging. - Chronic renal insufficiency with creatinine clearance of <30 ml/min/1.73m^2 by MDRD formula or with end state renal disease on dialysis. - History of hemorrhagic stroke. - Prior exposure to bococizumab or other investigational PCSK9 inhibitor. |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Hospital Italiano Regional del Sur | Bahia Blanca | Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca | Buenos Aires |
| Argentina | Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada | C.a.b.a | C.a.b.a. |
| Argentina | STAT Research S.A. | C.a.b.a | Caba |
| Argentina | CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A. | C.a.b.a. | Buenos Aires |
| Argentina | Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L. | Ciudad Autonoma De B. Aires | |
| Argentina | Hospital Britanico De Buenos Aires | Ciudad Autonoma de B. Aires | Buenos Aires |
| Argentina | Instituto Cardiovascular De Buenos Aires | Ciudad Autonoma de B. Aires | |
| Argentina | CEDIC - Consultorios Medicos | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Centro de Investigacion: AXISMED S.R.L. | Ciudad Autonoma de Buenos Aires | |
| Argentina | Investigaciones Medicas IMOBA S.R.L. | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Universidad Maimonides | Ciudad Autonoma De Buenos Aires | |
| Argentina | IMEP Instituto Medico Elsa Perez | Ciudadela | PCIA DE Buenos Aires |
| Argentina | Centro de Investigaciones Clinicas "Instituto del Corazon" | Cordoba | |
| Argentina | Centro Medico Luquez | Cordoba | |
| Argentina | Clinica Privada Colombo | Cordoba | |
| Argentina | Clinico Chutro SRL | Cordoba | |
| Argentina | ILAIM Instituto Latinoamericano de Investigaciones Medicas | Cordoba | |
| Argentina | Instituto Medico DAMIC S.R.L. | Cordoba | |
| Argentina | IPAC Caraffa | Cordoba | |
| Argentina | Clinica Coronel Suarez S.A. | Coronel Suarez | Buenos Aires |
| Argentina | Instituto de Cardiologia de Corrientes "Juana Fca. Cabral" | Corrientes | |
| Argentina | Hospital de Alta Complejidad "Pte. Juan Domingo Peron" | Formosa | PCIA DE Formosa |
| Argentina | CIPADI Centro Integral de Prevencion y Atencion en Diabetes | Godoy Cruz | Mendoza |
| Argentina | Framingham Centro Medico | La Plata | Buenos Aires |
| Argentina | CIMeL CHAHIN CHAHIN S.A. | Lanus Este | Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas Mar del Plata | Mar del Plata | Buenos Aires |
| Argentina | Hospital Central de Mendoza | Mendoza | |
| Argentina | Instituto Medico Aguero | Moron | PCIA DE Buenos Aires |
| Argentina | DIM Clinica Privada | Ramos Mejia | Buenos Aires |
| Argentina | Cordis - Instituto del Corazon | Resistencia | PCIA DE Chaco |
| Argentina | Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli" | Rosario | Pcia. DE Santa FE |
| Argentina | Instituto Medico Ceniclar - Central De Investigaciones Clinicas Argentina - Sanatorio De La Mujer | Rosario | Provincia DE Santa FE |
| Argentina | Centro Cardiovascular Salta | Salta | |
| Argentina | Cordis S.A. | Salta | |
| Argentina | Instituto Cardiovascular San Luis A.E. | San Luis | |
| Argentina | Centro Medico CCBR Tucuman | San Miguel de Tucuman | Tucuman |
| Argentina | Centro Modelo de Cardiologia | San Miguel De Tucuman | PCIA DE Tucuman |
| Argentina | Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A. | Santa Fe | PCIA DE Santa FE |
| Argentina | Centro De Investigaciones Clinicas Del Litoral S.R.L. | Santa Fe | PCIA DE Santa FE |
| Argentina | Hospital Provincial Dr. Jose Maria Cullen | Santa Fe | PCIA DE Santa FE |
| Argentina | Clinica Privada de Especialidades Medicas | Villa Maria | Cordoba |
| Argentina | Instituto de Investigaciones Clinicas Zarate | Zarate | Buenos Aires |
| Australia | Adelaide Medical Research | Ashford | South Australia |
| Australia | SA Heart | Ashford | South Australia |
| Australia | Eastern Health - Box Hill Hospital | Box Hill | Victoria |
| Australia | Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders | Camperdown | New South Wales |
| Australia | Royal Prince Alfred Hospital | Camperdown | New South Wales |
| Australia | Holy Spirit Northside Private Hospital Limited | Chermside | Queensland |
| Australia | Southern Adelaide Diabetes and Endocrine Service | Daws Park | South Australia |
| Australia | Department of Cardiology, Lyell McEwin Hospital | Elizabeth Vale | South Australia |
| Australia | The Northern Hospital | Epping | Victoria |
| Australia | Central Coast Neurosciences Research | Erina | New South Wales |
| Australia | Fremantle Hospital | Fremantle | Western Australia |
| Australia | Heart and Vascular Research | Fullarton | South Australia |
| Australia | Barwon Health-The Geelong Hospital | Geelong | Victoria |
| Australia | Central Coast Local Health District, Gosford Hospital | Gosford | New South Wales |
| Australia | Austin Health - Heidelberg Repatriation Hospital | Heidelberg West | Victoria |
| Australia | Royal Brisbane and Women's Hospital | Herston | Queensland |
| Australia | HPS Pharmacies | Joondalup | Western Australia |
| Australia | Joondalup Cardiovascular Trials Foundation Inc. | Joondalup | Western Australia |
| Australia | Launceston General Hospital | Launceston | Tasmania |
| Australia | Australian Clinical Research Network | Maroubra | New South Wales |
| Australia | Alfred Hospital | Melbourne | Victoria |
| Australia | Core Research Group Pty Ltd | Milton | Queensland |
| Australia | Redcliffe Hospital | Redcliffe | Queensland |
| Australia | Austrials Pty Ltd | Sherwood | Queensland |
| Australia | Gold Coast University Hospital | Southport | Queensland |
| Belgium | Algemeen Stedelijk Ziekenhuis | Aalst | Oost-vlaanderen |
| Belgium | ZNA Campus Middelheim | Antwerpen | |
| Belgium | Imeldaziekenhuis Bonheiden | Bonheiden | |
| Belgium | VZW Algemeen Ziekenhuis KLINA | Brasschaat | Antwerpen |
| Belgium | A.Z. St.Jan AV Brugge | Brugge | |
| Belgium | University Hospital Brussels - Centrum voor hart- en vaatziekten | Brussels | |
| Belgium | University Hospital Brussels- Diabeteskliniek | Brussels | |
| Belgium | Private Practice 'Cardiovascular Detection Center' | De Pinte | |
| Belgium | Az Sint Blasius | Dendermonde | Oost-vlaanderen |
| Belgium | ZOL Campus Sint-Jan | Genk | |
| Belgium | AZ Maria Middelares | Gent | |
| Belgium | AZ Sint Lucas Gent | Gent | Oost-vlaanderen |
| Belgium | Universitair Ziekenhuis Gent | Gent | Oost-vlaanderen |
| Belgium | Grand Hopital de Charleroi, Site St-Joseph | Gilly | |
| Belgium | Hygeia | Hasselt | |
| Belgium | Jessa Ziekenhuis | Hasselt | |
| Belgium | Sint-Franciskusziekenhuis | Heusden-Zolder | |
| Belgium | Centre Hospitalier Regional de Huy | Huy | |
| Belgium | Jan Yperman Ziekenhuis, Cardiology | Ieper | |
| Belgium | AZ Groeninge-Campus Loofstraat | Kortrijk | West-vlaanderen |
| Belgium | Centre Hospitalier De Jolimont - Lobbes | La Louviere (Haine-Saint-Paul) | |
| Belgium | Centre Hospitalier de Jolimont-Lobbes | La Louviere (Haine-Saint-Paul) | |
| Belgium | University hospitals Leuven | Leuven | |
| Belgium | University hospitals Leuven - Neurology department | Leuven | |
| Belgium | Centre Hospitalier Universitaire (CHU) de Liege | Liege | |
| Belgium | Huisartsenpraktijk Medilink | Linkebeek | |
| Belgium | Huisartsenpraktijk Luc Capiau | Massemen | |
| Belgium | AZ Sint-Maarten | Mechelen | Antwerp |
| Belgium | C.H.U. Ambroise Pare | Mons | |
| Belgium | Az Damiaan | Oostende | West-vlaanderen |
| Belgium | Mariaziekenhuis vzw | Overpelt | |
| Belgium | Az Glorieux | Ronse | Oost-vlaanderen |
| Belgium | AZ Nikolaas, Campus Moerland | Sint-Niklaas | Oost-vlaanderen |
| Belgium | Dr. Luc De Wolf - Private Practice | Tienen | |
| Brazil | Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto | Belem | PA |
| Brazil | CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA | Belo Horizonte | Minas Gerais |
| Brazil | Hospital Santa Isabel | Blumenau | Santa Catarina |
| Brazil | Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron | Campina Grande do Sul | PR |
| Brazil | CAEP - Centro Avançado de Estudos e Pesquisas Ltda. | Campinas | SP |
| Brazil | Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda. | Campinas | SAO Paulo |
| Brazil | Hospital Universitario - Associacao Educadora Sao Carlos - AESC | Canoas | RIO Grande DO SUL |
| Brazil | Hospital Santa Casa de Curitiba | Curitiba | PR |
| Brazil | Nucleo de Pesquisa Clínica | Curitiba | Parana |
| Brazil | Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV | Curitiba | PR |
| Brazil | Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda | Fortaleza | CE |
| Brazil | Covance Central Laboratory Services | Indianapolis | Indiana |
| Brazil | CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA | Minas Gerais | |
| Brazil | Hospital Mae de Deus - Instituto do Cancer | Porto Alegre | RIO Grande DO SUL |
| Brazil | Hospital Mae de Deus-Associacao Educadora de Sao Carlos-AESC/IMV - Instituto de Medicina Vascular | Porto Alegre | RIO Grande DO SUL |
| Brazil | Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC / IMV - Instituto de Medicina Vascular | Porto Alegre | RIO Grande DO SUL |
| Brazil | Instituto de Cardiologia do Rio Grande do Sul / Fundacao Universitaria de Cardiologia | Porto Alegre | RIO Grande DO SUL |
| Brazil | Irmandade Santa Casa de Misericordia de Porto Alegre | Porto Alegre | RIO Grande DO SUL |
| Brazil | Mae de Deus - Centro de Oncologia Radioterapica (COR) | Porto Alegre | RIO Grande DO SUL |
| Brazil | Centro de Pesquisas Medicas Basica e Clinica LTDA | Recife | PE |
| Brazil | Hospital Agamenon Magalhaes | Recife | Pernambuco |
| Brazil | CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA | Rio de Janeiro | RJ |
| Brazil | Fundacao Bahiana De Cardiologia | Salvador | BA |
| Brazil | HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia | Salvador | BA |
| Brazil | IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda | Sao Jose do Rio Preto | SAO Paulo |
| Brazil | CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda | Sao Paulo | |
| Brazil | CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz | Sao Paulo | |
| Brazil | FGM-Clinica Paulista de Doencas Cardiovasculares | Sao Paulo | |
| Brazil | Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP) | Sao Paulo | SP |
| Canada | LMC Diabetes & Endocrinology (Brampton) | Brampton | Ontario |
| Canada | Aviva Clinical Trial Group Inc. | Burlington | Ontario |
| Canada | JBN Medical Diagnostic Services Inc. | Burlington | Ontario |
| Canada | Philippe R. Beaudry Medicine Professional Corporation | Burlington | Ontario |
| Canada | Foothills Hospital/University of Calgary | Calgary | Alberta |
| Canada | LMC Diabetes & Endocrinology (Calgary) | Calgary | Alberta |
| Canada | Nanji Professional Corporation | Calgary | Alberta |
| Canada | Cambridge Cardiac Care Centre | Cambridge | Ontario |
| Canada | Vizel Cardiac Research - Saul Vizel Professional Medicine Corporation | Cambridge | Ontario |
| Canada | Ecogene-21 | Chicoutimi | Quebec |
| Canada | Q & T Research Chicoutimi | Chicoutimi | Quebec |
| Canada | Moran Medical Centre | Collingwood | Ontario |
| Canada | C & L Research | Fort Erie | Ontario |
| Canada | Q&T Recherche Outaouais Inc. | Gatineau | Quebec |
| Canada | Parkdale Medical Centre | Hamilton | Ontario |
| Canada | Kelowna Cardiology Associates | Kelowna | British Columbia |
| Canada | The Medical Arts Health Research Group | Kelowna | British Columbia |
| Canada | Stroke Prevention & Atherosclerosis Research Centre (SPARC) | London | Ontario |
| Canada | Western University - WCPHFM | London | Ontario |
| Canada | LMC Diabetes & Endocrinology (Markham) | Markham | Ontario |
| Canada | Omnispec Recherche Clinique Inc. | Mirabel | Quebec |
| Canada | G.A. Research Associates Ltd. | Moncton | New Brunswick |
| Canada | Diex Research Montreal, Inc. | Montreal | Quebec |
| Canada | Montreal Heart Institute | Montreal | Quebec |
| Canada | Newmarket Cardiology Research Group | Newmarket | Ontario |
| Canada | LMC Clinical Research Inc. (Oakville) | Oakville | Ontario |
| Canada | The Office of Dr. James Cha | Oshawa | Ontario |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Clinique des maladies lipidiques de Quebec | Quebec | |
| Canada | Recherche Clinique Sigma inc | Quebec | |
| Canada | Cardiology Research Associates of New Brunswick | Saint John | New Brunswick |
| Canada | London Road Diagnostic Clinic and Medical Centre | Sarnia | Ontario |
| Canada | Sarnia Institute of Clinical Research | Sarnia | Ontario |
| Canada | Scarborough Cardiology Research Associates Inc. | Scarborough | Ontario |
| Canada | Centre Hospitalier Universitaire de Sherbrooke - Hotel-Dieu | Sherbrooke | Quebec |
| Canada | Canadian Centre for Research on Diabetes | Smiths Falls | Ontario |
| Canada | Centre integre de sante et de services sociaux de Lanaudiere (CISSSL) | St-Charles-Borromee | Quebec |
| Canada | Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSA-CA) - | St-Georges, Beauce | Quebec |
| Canada | CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche | St-Jerome | Quebec |
| Canada | St-Jerome Medical Research Inc. | St-Jerome | Quebec |
| Canada | Health Science Centre | St. John's | NF |
| Canada | Health Sciences Centre | St. John's | NF |
| Canada | Brian Y.L. Wong Medicine Professional Corporation | Sudbury | Ontario |
| Canada | Dr. Adam Yeung Inc. | Surrey | British Columbia |
| Canada | Dr. Dante E. Manyari Inc. | Surrey | British Columbia |
| Canada | Dr. Kapil M. Bhagirath Medical Services Corporation | Surrey | British Columbia |
| Canada | Dr. Michael Kanakos Inc. | Surrey | British Columbia |
| Canada | Dr. Raymond Dong Inc. | Surrey | British Columbia |
| Canada | Dr. Richard Bon Inc. & Dr. Adam Yeung Inc. | Surrey | British Columbia |
| Canada | Dr. Stephanie Au, Inc. | Surrey | British Columbia |
| Canada | Dr. Stephen Pearce Inc. & Dr. Peter K.H. Tan Inc. | Surrey | British Columbia |
| Canada | Dr. Stephen S. Cheung Inc. | Surrey | British Columbia |
| Canada | Dr. Stephen S. Cheung Inc. | Surrey | British Columbia |
| Canada | SMH Cardiology Clinical Trials | Surrey | British Columbia |
| Canada | SMH Cardiology Clinical Trials Inc | Surrey | British Columbia |
| Canada | LMC Diabetes & Endocrinology (Thornhill) | Thornhill | Ontario |
| Canada | Canadian Phase Onward, Inc. | Toronto | Ontario |
| Canada | Dr. Anil K. Gupta Medicine Professional Corporation | Toronto | Ontario |
| Canada | JJ Dig Research LTD | Toronto | Ontario |
| Canada | LMC Diabetes & Endocrinology (Bayview) | Toronto | Ontario |
| Canada | C.I.C. Mauricie Inc. | Trois-Rivieres | Quebec |
| Canada | Discovery Clinical Services Ltd. | Victoria | British Columbia |
| Canada | Victoria Heart Institute Foundation | Victoria | British Columbia |
| Canada | LMC Clinical Research Inc. (Montreal) | Ville Saint-Laurent | Quebec |
| Canada | Dr. Mohan Babapulle Medicine Professional Cooperation | Waterloo | Ontario |
| Canada | Dr. Louis Yao, MD Office of | Weston | Ontario |
| Canada | St. Boniface Hospital | Winnipeg | Manitoba |
| Chile | Corporacion de Beneficencia Osorno | Osorno | Region DE LOS Lagos |
| Chile | Biomedica Research Group | Providencia Santiago | Metropolitana |
| Chile | Quantum Research | Puerto Varas | |
| Chile | CICAB | Santiago | Metropolitana |
| Chile | Complejo Asitencial Dr. Sotero del Rio | Santiago | Metropolitana |
| Chile | Hospital y CRS El Pino | Santiago | |
| Chile | Servicios Medicos Godoy | Santiago | Region Metropolitana |
| Chile | SMOLAM | Santiago | Metropolitana |
| Chile | Centro de Investigacion Clínica del Sur | Temuco | Region DE LA Araucania |
| Colombia | Clinica de la Costa LTDA | Barranquila | Atlantico |
| Colombia | Centro Cientifico Asistencial Jose Luis Accini S.A.S. | Barranquilla | Atlantico |
| Colombia | Corazon Ips S.A.S. | Barranquilla | Atlantico |
| Colombia | Corozan Ips Sas | Barranquilla | Atlantico |
| Colombia | Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS | Barranquilla | Atlantico |
| Colombia | Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA | Bogota D.C | Cundinamarca |
| Colombia | Dexadiab Servicios Medicos LTDA | Bogota D.C | Cundinamarca |
| Colombia | Hospital Universitario San Ignacio | Bogota D.C | Cundinamarca |
| Colombia | Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA. | Bogota D.C | Cundinamarca |
| Colombia | MedPlus Medicina Prepagada S.A. | Bogota D.C. | Cundinamarca |
| Colombia | Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO | Bogota D.C. | Cundinamarca |
| Colombia | Instituto del Corazon de Bucaramanga S.A. | Bucaramanga | Santander |
| Colombia | Fundacion Reina Isabel | Cali | Valle DEL Cauca |
| Colombia | Centro de Diagnostico Cardiologico LTDA. | Cartagena | Bolivar |
| Colombia | Fundación Cardiovacular de Colombia - Instituto del Corazón de Floridablanca | Floridablanca | Santander |
| Colombia | Asociacion IPS Medicos Internistas de Caldas | Manizales | Caldas |
| Colombia | Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM | Medellin | Antioquia |
| Colombia | Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A. | Medellin | Antioquia |
| Colombia | Hospital Pablo Tobon Uribe | Medellin | Antioquia |
| Colombia | Rodrigo Botero S.A.S | Medellin | Antioquia |
| Czechia | CCBR Czech Brno, s.r.o. | Brno | |
| Czechia | Kardiologicka Ambulance | Brno | Jihomoravsky KRAJ |
| Czechia | EDUMED s.r.o. | Broumov | Kralovehradecky KRAJ |
| Czechia | DIKa centrum s.r.o., Kardiologicka a interni ambulance | Havirov | |
| Czechia | Fakultni nemocnice Hradec Kralove | Hradec Kralove | |
| Czechia | Fakultni nemocnice Hradec Kralove, III. Interni gerontometabolicka klinika | Hradec Kralove | |
| Czechia | Edumed S.R.O. | Jaromer | Kralovehradecky KRAJ |
| Czechia | FREMLOVA APHOTECA s.r.o. | Litovel | Czech Republic |
| Czechia | Kardio interna s.r.o. | Litovel | |
| Czechia | Fakultni Nemocnice Olomouc | Olomouc | |
| Czechia | Fakultni Nemocnice Olomouc | Olomouc | |
| Czechia | MUDr. Jan Vrkoc s.r.o. | Ostrava | Moravskoslezsky KRAJ |
| Czechia | BENU Lekarna | Pardubice | Czech Republic |
| Czechia | CCBR Czech a.s. | Pardubice | |
| Czechia | Pv-Kardiologie S.R.O. | Pardubice | Pardubicky KRAJ |
| Czechia | Kardiologie Plzen s.r.o. | Plzen | |
| Czechia | Centrum kardiovaskularni prevence 1. LF UK a TN | Praha | |
| Czechia | Fakultni poliklinika Vseobecne fakultni nemocnice v Praze | Praha 2 | |
| Czechia | CCBR Czech Prague, s.r.o | Praha 3 | |
| Czechia | Kardiologie a interni lekarstvi | Praha 5 | |
| Czechia | NEFROMED, s.r.o. | Praha 6 | |
| Czechia | Interna a kardiologie s.r.o. | Roznov pod Radhostem | |
| Czechia | Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice | Svitavy | |
| Czechia | Lekarna U Nemocnice | Tabor | |
| Czechia | Vseobecna kardiologicka ambulance s.r.o. | Tabor | |
| Czechia | Kardiologicka ambulance | Trutnov | Kralovehradecky KRAJ |
| Czechia | Lekarna na Poliklinice | Trutnov | Kralovehradecky KRAJ |
| Czechia | Lekarna Hradebni s.r.o. | Uherske Hradiste | |
| Czechia | MUDr. Antonin Dufka, kardiologicka ambulance | Uherske Hradiste 1 | |
| Czechia | MUDr. Nina Zemkova s.r.o. | Uherske Hradiste 1 | |
| Czechia | KIGE s.r.o. | Znojmo | |
| Denmark | Sygehus Sonderjylland Aabenraa | Aabenraa | |
| Denmark | Aalborg Universitetshospital, Lipidklinikken | Aalborg | |
| Denmark | CCBR Aalborg | Aalborg | |
| Denmark | Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning | Aarhus | |
| Denmark | Aarhus Universitetshospital | Aarhus N | |
| Denmark | CCBR Ballerup | Ballerup | |
| Denmark | Bispebjerg og Frederiksberg Hospital | Copenhagen NV | |
| Denmark | Rigshospitalet | Copenhagen Oe | |
| Denmark | Sydvestjysk Sygehus | Esbjerg | |
| Denmark | Frederiksberg Hospital | Frederiksberg | |
| Denmark | Glostrup Hospital | Glostrup | |
| Denmark | Herlev Universitetshospital, Kardiologisk afdeling S | Herlev | |
| Denmark | Regionshospitalet Herning | Herning | |
| Denmark | Hillerod Hospital | Hillerod | |
| Denmark | Hvidovre Universitetshospital, Hjerte-lungemedicinsk afdeling | Hvidovre | |
| Denmark | Amager Hospital | Kobenhavn S. | |
| Denmark | Region Sjaelland Sygehus Nord, Koge Sygehus | Koge | |
| Denmark | Kolding Sygehus | Kolding | |
| Denmark | Region Sjaelland Naestved Sygehus | Naestved | |
| Denmark | Nykobing F. Sygehus-Medicinsk afdeling | Nykobing F. | |
| Denmark | Regionshospitalet Randers | Randers | |
| Denmark | Regionshospitalet Silkeborg, Hjerte Projektkontor | Silkeborg | |
| Denmark | Slagelse Sygehus | Slagelse | |
| Denmark | Svendborg Sygehus | Svendborg | |
| Denmark | CCBR Vejle | Vejle | |
| Denmark | Hospitalsenheden Midt, Regionshospital Viborg | Viborg | |
| Finland | Linnan Klinikka Oy | Hameenlinna | |
| Finland | Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U | Helsinki | |
| Finland | Helsinki University Central Hospital | Helsinki | |
| Finland | Mehilainen Toolo | Helsinki | |
| Finland | Ita-Suomen laakarikeskus Oy | Joensuu | |
| Finland | Studycor Oy | Jyvaskyla | |
| Finland | Laeaekaerikeskus Aava Kerava | Kerava | |
| Finland | Menoa oy | Kinkomaa | |
| Finland | Kokkolan Keskussairaala | Kokkola | |
| Finland | Mewell liikuntaklinikka | Kotka | |
| Finland | Itae-Suomen Laeaekaeritalo Oy | Kuopio | |
| Finland | Terveystalo Kuopio | Kuopio | |
| Finland | Oulu Mentalcare Oy | Oulu | |
| Finland | Oulu University Hospital | Oulu | |
| Finland | Terveystalo Oulu, Diapolis | Oulu | |
| Finland | Porin Laakaritalo Oy | Pori | |
| Finland | Terveystalo Siilinjarvi | Siilinjarvi | |
| Finland | FinnMedi Oy | Tampere | |
| Finland | Terveystalo Pulssi | Turku | |
| Finland | Turku University Hospital | Turku | |
| Finland | Vantaan Tutkimuskeskus | Vantaa | |
| France | CHU Jean Minjoz Cardiologie | Besancon | |
| France | Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat | Bourg En Bresse Cedex 10000 | |
| France | CHU de Caen | Caen cedex 9 | |
| France | Centre Hospitalier de Cannes- Service de Cardiologie | Cannes Cedex | |
| France | Centre Hospitalier Sud-Francilien | Corbeil-Essonnes | |
| France | Scp Cardiovasculaire De L'Est | Essey-Les-Nancy | |
| France | Centre Hospitalier Louis Pasteur | Le Coudray | |
| France | Hopital La Louviere | Lille | |
| France | Centre Hospitalier Saint Philibert | Lomme | |
| France | Hopital Cardiovasculaire Et Pneumologique Louis Pradel | Lyon Cedex 03 | |
| France | Hopital Arnaud de Villeneuve | Montpellier cedex 5 | |
| France | CHU de Nantes - Hopital Nord Laennec | Nantes | |
| France | Nouvelles Cliniques Nantaises | Nantes | |
| France | CHU Caremeau | Nimes | |
| France | CHU Caremeau | Nimes cedex 9 | |
| France | Centre Hospitalier de PAU | PAU | |
| France | Hopital Cardiologique | Pessac cedex | |
| France | CHU de Poitiers | Poitiers cedex | |
| France | CHU de Renes Hopital de Pontchaillou | Rennes Cedex 9 | |
| France | CHU de Toulouse | Toulouse cedex 9 | |
| France | Hopital Guy Chatiliez | Tourcoing | |
| France | Hopital Trousseau | Tours Cedex 9 | |
| France | Centre Hospitalier (CH) de Valenciennes | Valenciennes | |
| France | Polyclinique Vauban | Valenciennes | |
| Germany | Klinikum Altenburger Land Gmbh | Altenburg | |
| Germany | Zentralklinik Bad Berka GmbH | Bad Berka | |
| Germany | Forschungszentrum Dr. med Irma Schoell | Bad Homburg | |
| Germany | Universitaets Herzzentrum Freiburg Bad Krozingen | Bad Krozingen | Baden-wuerttemberg |
| Germany | Berlin Research Centre-Synexus Clinical Research GmbH | Berlin | |
| Germany | Deutsches Herzzentrum Berlin | Berlin | |
| Germany | DRK Kliniken Kopenick, Zentrum Klinische Forschung | Berlin | |
| Germany | Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH | Berlin | |
| Germany | Klinische Forschung Berlin-Mitte GmbH | Berlin | |
| Germany | Medizinisches Versorgungszentrum am Bahnhof Spandau | Berlin | |
| Germany | POLIKUM Institut GmbH | Berlin | |
| Germany | Synexus Clinical Research GmbH | Berlin | |
| Germany | Klinikum Bielefeld | Bielefeld | |
| Germany | Bochum Research Centre-Synexus Clinical Research GmbH | Bochum | |
| Germany | MediClin Reha-Zentrum Spreewald | Burg-Spreewald | |
| Germany | Klinikum Coburg | Coburg | |
| Germany | HELIOS Amper-Klinikum Dachau | Dachau | |
| Germany | Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel | Dortmund | |
| Germany | Kardiologische Praxisgemeinschaft | Dortmund | |
| Germany | St. Johannes-Hospital | Dortmund | |
| Germany | GWT-TUD GmbH, Studienzentrum Professor Hanefeld | Dresden | |
| Germany | Klinsche Forschung Dresden GmbH | Dresden | |
| Germany | Praxis Dr. med. Christoph Axthelm | Dresden | |
| Germany | Gemeinschaftspraxis Dr. Hagemann/Breiderhoff/Durfeld | Essen | |
| Germany | Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg | Essen | |
| Germany | Medizentrum Essen Borbeck | Essen | |
| Germany | Studienzentrum | Essen | |
| Germany | Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin | Falkensee | |
| Germany | Clinphenomics Gmbh & Co Kg, Studienzentrum | Frankfurt | |
| Germany | Synexus Clinical research GmbH | Frankfurt | |
| Germany | IKF Institut fuer klinische Forschung Frankfurt | Frankfurt am Main | |
| Germany | Gemeinschaftspraxis im Altstadt Carree | Fulda | Hessen |
| Germany | Klinik und Poliklinik fuer Innere Medizin B-Kardiologie, Angiologie, Pulmologie, Internistische | Greifswald | |
| Germany | Cardiologicum Hamburg | Hamburg | |
| Germany | Praxis Dr. med Cornelia Brauer | Hamburg | |
| Germany | Klinische Forschung Hannover-Mitte GmbH | Hannover | |
| Germany | Medizinische Universtatsklinik Heidelberg | Heidelberg | Baden-wurttemberg |
| Germany | Universitatsklinikum des Saarlandes Klinik fur Innere Medizin III | Homburgsaar | |
| Germany | Praxis Dr. Heister | Kamp-Lintfort | |
| Germany | Studienzentrum Dr. Appel | Kassel | |
| Germany | Zentrum fuer klinische Forschung | Koeln | |
| Germany | Gemeinschaftspraxis Dr. Klein / Minnich | Kuenzing | |
| Germany | Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden. | Lahr | |
| Germany | Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut | Leipzig | |
| Germany | Polikum Institut Leipzig GmbH | Leipzig | |
| Germany | Synexus Clinical research GmbH | Leipzig | |
| Germany | Synexus Leipzig Clinical Research Centre | Leipzig | |
| Germany | Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III | Luedenscheid | |
| Germany | Klinikum Lunen, St. Marienhospital | Lunen | |
| Germany | SMO.MD GmbH - Zentrum für klinische Studien | Magdeburg | |
| Germany | SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit | Magdeburg | |
| Germany | Pfuetzner Science & Health Institute-Gmbh | Mainz | |
| Germany | Ze:ro Arztpraxen | Mannheim | Baden-wurttemberg |
| Germany | Klinikum fuer Herz- & Kreislauferkrankungen | Muenchen | |
| Germany | Klinikum Der Universitat Munchen | Munchen | |
| Germany | Staedtisches Klinikum Muenchen GmbH | Munich | |
| Germany | Zentrum Klinische Studien Neuwied (ZKSN) | Neuwied | Rheinland Pfalz |
| Germany | Kardiologische Praxis Northeim | Northeim | |
| Germany | Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin | Nurnberg | |
| Germany | Allgemeinmedizinisch-Internistische Praxisgemeinschaft | Offenbach | |
| Germany | Praxis Dres. Med Naudts und Nowack | Rodgau | |
| Germany | Klinik am See Rehabilitationszentrum fur Innere Medizin | Rudersdorf | |
| Germany | Gemeinschaftspraxis Schwabenheim | Schwabenheim | Rhineland-palatinate |
| Germany | Klinische Forschung Schwerin GmbH | Schwerin | Mecklenburg-vorpommern |
| Germany | Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Burger | Soest | |
| Germany | Praxisgemeinschaft Stuhr-Brinkum | Stuhr-Brinkum | |
| Germany | Robert-Bosch-Krankenhaus | Stuttgart | |
| Germany | Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie | Warendorf | |
| Germany | Kardiologische Praxis | Wermsdorf | |
| Germany | ForschungszentrumRuhr KliFoCenter GmbH | Witten | |
| Hungary | DRC Kft. | Balatonfured | |
| Hungary | DRC Kft. | Balatongyorok | |
| Hungary | Kardiologiai Maganrendelo | Bekescsaba | |
| Hungary | Grof Tisza Istvan Korhaz Berettyoujfalu | Berettyoujfalu | |
| Hungary | Budapesti Szent Ferenc Korhaz | Budapest | |
| Hungary | Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet | Budapest | |
| Hungary | Egyesitett Szent Istvan Korhaz es Szent Laszlo Korhaz | Budapest | |
| Hungary | Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Budapest | |
| Hungary | Semmelweis Egyetem | Budapest | |
| Hungary | Semmelweis Egyetem | Budapest | |
| Hungary | Synexus Magyarorszag Kft | Budapest | |
| Hungary | Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly | Budapest | |
| Hungary | Szent Rokus Korhaz | Budapest | |
| Hungary | Debreceni Egyetem | Debrecen | |
| Hungary | Synexus Magyarorszag Kft. | Gyula | |
| Hungary | Edes Szivunk Egeszsegkozpont Kft. | Hajduszoboszlo | |
| Hungary | BKS Research Kft., Albert Schweitzer Korhaz | Hatvan | |
| Hungary | Somogy Megyei Kaposi Mór Oktató Kórház | Kaposvar | |
| Hungary | Bacs-Kiskun Megyei Korhaz | Kecskemet | Bacs-kiskun |
| Hungary | Jutrix Egeszsegugyi Kft | Kecskemet | |
| Hungary | Megyei Flor Ferenc Korhaz | Kistarcsa | |
| Hungary | Pest Megyei Flor Ferenc Korhaz | Kistarcsa | |
| Hungary | Josa Andras Oktatokorhaz | Nyiregyhaza | |
| Hungary | Medifarma-98 Kft. | Nyiregyhaza | |
| Hungary | Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika | Pecs | |
| Hungary | Pecsi Tudomanyegyetem AOK, II. | Pecs | Baranya |
| Hungary | Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika | Szeged | Csongrad |
| Hungary | Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Szekesfehervar | Fejer |
| Hungary | Mentahaz Maganorvosi Kozpont | Szekesfehervar | |
| Hungary | Hetenyi Geza Korhaz | Szolnok | |
| Hungary | Markusovszky Egyetemi Oktatokarhaz | Szombathely | |
| Hungary | Dr. Sydo es Tsa Kft. | Veszprem | |
| Hungary | Zala Megyei Korhaz | Zalaegerszeg | |
| Hungary | Zala Megyei Korhaz, Diabetológiai Szakrendelés | Zalaegerszeg | |
| India | Apex Heart Institute (A Unit of TCVS Pvt. Ltd) | Ahmedabad | Gujarat |
| India | Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre | Ahmedabad | Gujarat |
| India | SAL Hospital | Ahmedabad | Gujarat |
| India | M.V. Hospital And Research Centre | Lucknow | Uttar Pradesh |
| India | Jehangir Clinical Development Centre Pvt. Ltd. | Pune | Maharashtra |
| India | Apple Hospital | Surat | Gujarat |
| India | BAPS - Pramukh Swami Hospital | Surat | Gujarat |
| India | Unicare Heart Institute & Research Center | Surat | Gujarat |
| India | Rhythm Heart Institute | Vadodara | Gujarat |
| Ireland | Beaumont Hospital | Dublin | Leinster |
| Ireland | St James's Hospital | Dublin | |
| Israel | Barzilai Medical Center | Ashkelon | |
| Israel | Ben Yair Community Clinic - Clalit Health Services | Beer Sheva | |
| Israel | Heart Institute, Hillel Yaffe Medical Center | Hadera | |
| Israel | Cardiovascular Clinical Research Institute | Haifa | |
| Israel | Rambam Medical Center | Haifa | |
| Israel | Edith Wolfson Medical Center | Holon | |
| Israel | Hadassah Ein Kerem Medical Center | Jerusalem | |
| Israel | Meir Medical Center | Kfar Sava | |
| Israel | Meir Medical Center | Kfar-Saba | |
| Israel | Galilee Medical Center, Cardiology Department | Nahariya | |
| Israel | E.M.M.S Nazareth Hospital | Nazareth | |
| Israel | Sha'aria Clinic, Clalit Health Services | Petach Tikva | |
| Israel | Rabin Medical Center | Petah Tikva | |
| Israel | Rabin Medical Center, Beilinson Hospital | Petah Tikva | |
| Israel | Rabin Medical Center-Beilinson Hospital | Petah Tikva | |
| Israel | Shuali Community Clinic, Clalit Health Services | Raanana | |
| Israel | Department of Neurology & Sagol Neuroscience Center | Ramat Gan | |
| Israel | Heart Institute, Kaplan Medical Center | Rehovot | |
| Israel | Kaplan Medical Center Metabolism and Diabetes Clinic, Kaplan Medical Center | Rehovot | |
| Israel | Internal Medicine A, Ziv Medical Center | Safed | |
| Israel | Ziv Medical Center | Safed | |
| Israel | Assuta Medical Center | Tel Aviv | |
| Israel | Tel Aviv Sourasky Medical Center | Tel Aviv | Tel-aviv |
| Israel | The Chaim Sheba Medical Center | Tel Hashomer | |
| Israel | Tel Aviv Sourasky Medical Center | Tel-Aviv | |
| Italy | S. C. Cardiologia INRCA | Ancona | |
| Italy | Ospedale Civile Regionale San Martino, Belluno | Belluno | |
| Italy | Azienda Ospedaliera G. Brotzu | Cagliari | |
| Italy | AOU Policlinico "Mater Domini" UOC di Medicina Interna | Catanzaro | CZ |
| Italy | Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni | Lecco | Province OF Lecco |
| Italy | Ospedale S. L. Mandic di Merate | Merate | Lecco |
| Italy | Covance Central Laboratory Services | Meyrin/Geneve | Geneve |
| Italy | Unità Operativa Solventi e Unità Poliambulatorio | Milan | |
| Italy | Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli | Napoli | |
| Italy | Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli | Napoli | |
| Italy | Dipartimento delle Patologie Emergenti, Unita di Medicina Interna e Dislipidemie Genetiche | Palermo | PA |
| Italy | Ospedale S. Maria della Misericordia -Dipartimento di Medicina, Medicina Interna, | Perugia | PG |
| Italy | A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS | Reggio Emilia | |
| Italy | AUSL Della Romagna-Ospedale Infermi | Rimini | |
| Italy | Dip Medicina Interna e Specialita Mediche, Policlinico Umberto I | Roma | RM |
| Italy | Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia | Rome | RM |
| Italy | Policlinico Umberto I di Roma | Rome | RM |
| Italy | Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo | Rovigo | |
| Italy | Ospedale G. Fracastoro | San Bonifacio | Verona |
| Italy | A.O. Treviglio e Caravaggio | Treviglio (BG) | Bergamo |
| Italy | Azienda Ospedaliera Universitaria Santa Maria della Misericordia | Udine | |
| Italy | AOUI di Verona - Ospedale Civile Maggiore Borgo Trento | Verona | VR |
| Korea, Republic of | Dong-A University Hospital | Busan | |
| Korea, Republic of | Inje University Busan Paik Hospital | Busan | |
| Korea, Republic of | Chungbuk National University Hospital | Cheongju-si | Chungcheonbuk-do |
| Korea, Republic of | Kangwon National University Hospital | Chuncheon-si | Gangwon-do |
| Korea, Republic of | Daegu Catholic University Medical Center | Daegu | |
| Korea, Republic of | Dongguk University Ilsan Hospital | Goyang-si | Gyeonggi-do |
| Korea, Republic of | Inje University Ilsan Paik Hospital | Goyang-Si | Gyeonggi-do |
| Korea, Republic of | Myongji Hospital | Goyang-si | Gyeonggi-do |
| Korea, Republic of | Donguk University Gyeongju Hospital | Gyeongju-si | Gyeongbuk |
| Korea, Republic of | Gachon University Gil Medical Center | Incheon | |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do |
| Korea, Republic of | Asan Medical Center | Seoul | |
| Korea, Republic of | Gangnam Severance Hospital, Yonsei University Health System | Seoul | |
| Korea, Republic of | Hallym University Kangdong Sacred Heart Hospital | Seoul | |
| Korea, Republic of | Seoul Medical Center | Seoul | |
| Korea, Republic of | Seoul Metropolitan Government - Seoul National University Boramae Medical Center | Seoul | |
| Korea, Republic of | The Catholic University Of Korea Seoul St.Marys Hospital | Seoul | |
| Korea, Republic of | Ajou University Hospital | Suwon-si | Gyeonggi-do |
| Korea, Republic of | Uijeongbu St. Mary's Hospital-The Catholic University of Korea | Uijeongbu-si | Gyeonggi-do |
| Korea, Republic of | Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital | Wonju-Si | Gangwon-do |
| Korea, Republic of | Yonsei University Wonju Severance Christian Hospital | Wonju-si | Gangwon-do |
| Mexico | Hospital Del Pacifico,Centro De Investigacion Clinica Del Pacifico Cicpa,Torre Medica Del Pacifico | Acapulco | Guerrero |
| Mexico | Centro de Investigacion Clinica del Pacifico, S.A. de C.V. | Acapulco de Juarez | Guerrero |
| Mexico | Hospital Cardiologica Aguascalientes | Aguascalientes | |
| Mexico | Instituto Biomedico De Investigacion A.C. | Aguascalientes | |
| Mexico | Consultorio Dr. Leocadio Gerardo Munoz Beltran | Cd. Juarez | Chihuahua |
| Mexico | Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia | Chihuahua | |
| Mexico | Investigacion en Salud y Metabolismo S.C | Chihuahua | |
| Mexico | Unidad De Investigacion En Salud De Chihuahua S.C. | Chihuahua | |
| Mexico | Hospital Inovamed Cuernavaca (Emergencies) | Cuernavaca | Morelos |
| Mexico | Instituto de Diabetes Obesidad y Nutricion, S.C. | Cuernavaca | Morelos |
| Mexico | Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. | Culiacan | Sinaloa |
| Mexico | Hospital Angeles Culiacan | Culiacan | Sinaloa |
| Mexico | Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran | Distrito Federal | |
| Mexico | Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C. | Durango | |
| Mexico | Centro de Investigacion Medica Integral S.C. | Guadalajara | Jalisco |
| Mexico | Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez | Guadalajara | Jalisco |
| Mexico | Icle S.C. | Guadalajara | Jalisco |
| Mexico | Unidad de Investigacion Clinica y Atencion Medica Hepa S.C. | Guadalajara | Jalisco |
| Mexico | Centro Especializado en Diabetes Obesidad y Prevencion de Enfermedades Cardiovasculares, SC. | Mexico | DF |
| Mexico | Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiovasculares, S.C. | Mexico | |
| Mexico | Consultorio de Endocrinologia y Nutriologia | Mexico | Distrito Federal |
| Mexico | Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran" | Mexico | Distrito Federal |
| Mexico | Operadora de Hospitales Angeles S.A. de C.V. (Emergencies) | Mexico | Distrito Federal |
| Mexico | Cardiolink Clin Trials, S.C. | Monterrey | Nuevo LEON |
| Mexico | CRI Centro Regiomontano de Investigacion SC | Monterrey | Nuevo LEON |
| Mexico | Global Trial Research Center S.A. de C.V. | Monterrey | Nuevo LEON |
| Mexico | Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey | Nuevo LEON |
| Mexico | Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V. | Pachuca | Hidalgo |
| Mexico | Clinical Trials Mexico, S.A. de C.V. | Pachuca de Soto | Hidalgo |
| Mexico | Pharmacology and Clinical Research S.A. de C.V. | Queretaro | |
| Mexico | Centro Integral Medico SJR S.C | San Juan del Rio | Queretaro |
| Mexico | Cardioarritmias e Investigacion S.C. | San Luis Potosi | |
| Mexico | Hospital Central "Dr. Ignacio Morones Prieto" | San Luis Potosi | |
| Mexico | Hospital Lomas de San Luis lntemacional (Emergencies) | San Luis Potosi | |
| Mexico | Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C. | Tampico | Tamaulipas |
| Mexico | Centro Especializado En Diabetes Y Metabolismo | Veracruz | |
| Mexico | Centro De Especialidades Medicas Del Estado De Veracruz | Xalapa | Veracruz |
| Netherlands | Noordwest Ziekenhuisgroep | Alkmaar | |
| Netherlands | EB Flevoresearch | Almere | |
| Netherlands | Meander Medical Center | Amersfoort | |
| Netherlands | Meander Medisch Centrum | Amersfoort | |
| Netherlands | Amstelland Hospital | Amstelveen | |
| Netherlands | Academic Medical Center | Amsterdam | |
| Netherlands | Bovenij Ziekenhuis | Amsterdam | |
| Netherlands | OLVG, locatie West | Amsterdam | |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | |
| Netherlands | VU University Medical Center | Amsterdam | |
| Netherlands | Gelre Hospitals | Apeldoorn | |
| Netherlands | Rode Kruis Ziekenhuis | Beverwijk | |
| Netherlands | Tergooi Ziekenhuis | Blaricum | |
| Netherlands | Amphia Ziekenhuis | Breda | |
| Netherlands | Andro Medical Research B.V. | Breda | |
| Netherlands | Reinier de Graaf Ziekenhuis | Delft | |
| Netherlands | Bronovo Ziekenhuis | Den Haag | |
| Netherlands | Hagaziekenhuis | Den Haag | |
| Netherlands | Hedramed | Den Haag | |
| Netherlands | Deventer Ziekenhuis | Deventer | |
| Netherlands | Van Weel Bethesda Hospital | Dirksland | |
| Netherlands | Slingeland Ziekenhuis | Doetinchem | |
| Netherlands | Albert Schweitzer Ziekenhuis-Albert Schweitzer Hospital | Dordrecht | |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | |
| Netherlands | Andromed Eindhoven | Eindhoven | |
| Netherlands | Heartcentre Catharina Hospital | Eindhoven | |
| Netherlands | Medisch Spectrum Twente | Enschede | |
| Netherlands | Beatrix Hospital | Gorinchem | |
| Netherlands | Beatrix Ziekenhuis | Gorinchem | |
| Netherlands | Groene Hart Ziekenhuis | Gouda | |
| Netherlands | Martini Ziekenhuis | Groningen | |
| Netherlands | University Medical Center Groningen | Groningen | |
| Netherlands | Spaarne Gasthuis | Haarlem | |
| Netherlands | Ropcke Zweers Hospital | Hardenberg | |
| Netherlands | St. Jansdal Ziekenhuis | Harderwijk | |
| Netherlands | Tjongerschans Ziekenhuis | Heerenveen | Friesland |
| Netherlands | Zuyderland | Heerlen | |
| Netherlands | Zuyderland Medisch Centrum | Heerlen | |
| Netherlands | Treant Zorggroep, location Bethesda | Hoogeveen | |
| Netherlands | Vascular Research Centre | Hoorn | |
| Netherlands | Quality Care Research | Kloosterhaar | |
| Netherlands | Medisch Centrum Leeuwarden | Leeuwarden | |
| Netherlands | Alrijne Ziekenhuis | Leiden | |
| Netherlands | Leiden University Medical Center | Leiden | |
| Netherlands | Alrijne Ziekenhuis | Leiderdorp | |
| Netherlands | GCM Maarssenbroek | Maarssen | |
| Netherlands | Maastricht University Medical Center | Maastricht | |
| Netherlands | Isala Diaconessenhuis | Meppel | |
| Netherlands | St Antonius Hospital | Nieuwegein | |
| Netherlands | Canisius Wilhelmina Ziekenhuis | Nijmegen | |
| Netherlands | Radboud University Nijmegen Medical Centre | Nijmegen | |
| Netherlands | Waterland Hospital | Purmerend | |
| Netherlands | Andro Medical Research B.V. | Rotterdam | |
| Netherlands | Hedramed | Rotterdam | |
| Netherlands | Ikazia Ziekenhuis | Rotterdam | |
| Netherlands | Rotterdam Research Institute | Rotterdam | |
| Netherlands | St. Franciscus Gasthuis | Rotterdam | Zuid-holland |
| Netherlands | Zuyderland MC | Sittard-Geleen | Limburg |
| Netherlands | D&A Research and Genetics | Sneek | |
| Netherlands | Ziekenhuis Rivierenland | Tiel | |
| Netherlands | Elisabeth TweeSteden Ziekenhuis (ETZ) | Tilburg | |
| Netherlands | Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis) | Tilburg | |
| Netherlands | St. Elisabeth Ziekenhuis | Tilburg | |
| Netherlands | Bernhoven Ziekenhuis | Uden | |
| Netherlands | EB Utrecht | Utrecht | |
| Netherlands | Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU | Utrecht | |
| Netherlands | University Medical Center Utrecht | Utrecht | |
| Netherlands | Maxima Medisch Centrum | Veldhoven | |
| Netherlands | VieCuri Medisch Centrum | Venlo | |
| Netherlands | Twee Steden Ziekenhuis | Waalwijk | |
| Netherlands | Het Lange Land Ziekenhuis | Zoetermeer | Zuid-holland |
| Netherlands | Klinisch Onderzoek Praktijk Zoetermeer | Zoetermeer | |
| Netherlands | Albert Schweitzer Hospital | Zwijndrecht | |
| Netherlands | Isala | Zwolle | Overijssel |
| New Zealand | Auckland City Hospital | Auckland | |
| New Zealand | Middlemore Clinical Trials | Auckland | |
| New Zealand | North Shore Hospital, Laboratory | Auckland | |
| New Zealand | North Shore Hospital- Inpatient Pharmacy | Auckland | |
| New Zealand | Optimal Clinical Trials | Auckland | |
| New Zealand | Lipid and Diabetes Research Group | Christchurch | |
| New Zealand | Southern Clinical Trials Riccarton | Christchurch | |
| New Zealand | Southern Clinical Trials Shirley Ltd Don Beavan Medical Research Centre | Christchurch | |
| New Zealand | Hawke's Bay Hospital | Frimley | Hastings |
| New Zealand | Henderson Medical Centre | Henderson | Auckland |
| New Zealand | Taranaki Base Hospital | New Plymouth | |
| New Zealand | Papamoa Pines Medical Centre | Papamoa | |
| New Zealand | Rotorua Hospital | Rotorua | |
| New Zealand | North Shore Hospital | Takapuna | Auckland |
| New Zealand | Clinical Horizons NZ Ltd | Tauranga | |
| New Zealand | Clinical Trials Unit,Bay of Plenty(BOP) Clinical School | Tauranga | |
| New Zealand | CCDHB, Wellington Hospital, Clinical Measurement Unit | Wellington | |
| New Zealand | Wellington Hospital | Wellington | |
| New Zealand | Wellington Regional Hospital | Wellington | |
| Poland | """OSTEO-MEDIC"" s.c. Artur Racewicz, Jerzy Supronik" | Bialystok | Podlaskie |
| Poland | "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik | Bialystok | |
| Poland | Podlaski Osrodek Kardiologii Janusz Korecki | Bialystok | Podlaskie |
| Poland | Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial | Brzozow | Podkarpackie |
| Poland | Nzoz Centrum Medyczne Kermed | Bydgoszcz | Kujawsko-pomorskie |
| Poland | NZOZ Vitamed | Bydgoszcz | Kujawsko-pomorskie |
| Poland | NZOZ Vitamed -Ga¿aj I Cichomski sp.j | Bydgoszcz | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu, | Bytom | Slaskie |
| Poland | Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej | Elblag | Warminsko-mazurskie |
| Poland | Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna | Gdansk | Pomorskie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna | Gdansk | Pomorskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Gdansku | Gdansk | Pomorskie |
| Poland | Gabinet Kardiologiczno - lnternistyczny | Gdynia | Pomorskie |
| Poland | Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni | Gdynia | |
| Poland | NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych | Gdynia | Pomorskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Gdyni | Gdynia | Pomorskie |
| Poland | Specjalistyczna Praktyka Lekarska Piotr Kubalski | Grudziadz | Kujawsko-pomorskie |
| Poland | Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna | Jelenia Gora | Dolnoslaskie |
| Poland | Bogna Gabrylewicz Andrzej Ochala Unimed s.c. | Katowice | Slaskie |
| Poland | NZOZ Terapia Optima | Katowice | Slaskie |
| Poland | Pro Familia Altera Poradnia Wielospecjalistyczna | Katowice | Slaskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Katowicach | Katowice | Mazowieckie |
| Poland | Prywatny Gabinet Lekarski Marianna Janion | Kielce | Swietokrzyskie |
| Poland | CENTRUM MEDYCZNE A-Z Clinic | Krakow | Malopolskie |
| Poland | Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna | Krakow | Malopolskie |
| Poland | Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddzial Szybkiej Diagnostyki | Krakow | Malopolskie |
| Poland | Krakowskie Centrum Medyczne Sp. z o.o. | Krakow | Malopolskie |
| Poland | Landa Specjalistyczne Gabinety Lekarskie | Krakow | Malopolskie |
| Poland | NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o. | Krakow | |
| Poland | Nzoz Gall-Med | Krakow | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, | Krakow | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie, | Krakow | Malopolskie |
| Poland | SP ZOZ Szpital Uniwersytecki w Krakowie | Krakow | |
| Poland | Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii | Krakow | Malopolskie |
| Poland | INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie | Krosno | Podkarpackie |
| Poland | "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider | Lodz | Lodzkie |
| Poland | Gabinet Lekarski Malgorzata Saryusz-Wolska | Lodz | Lodzkie |
| Poland | Specjalistyczny Osrodek Medycyny Wieku Dojrzalego | Lodz | |
| Poland | Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. | Lodz | Lodzkie |
| Poland | SPZOZ Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego | Lodz | Iodzkie |
| Poland | "TWOJA PRZYCHODNIA" Sp. Z o.o | Lublin | |
| Poland | Clinical Best Solutions | Lublin | Lubelskie |
| Poland | KO-MED Centra Kliniczne Lublin II | Lublin | Lubelskie |
| Poland | Optimamed Specjalistyczne Gabinety Lekarskie | Lublin | Lubelskie |
| Poland | NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska | Myslenice | Malopolskie |
| Poland | NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska | Myslenice | |
| Poland | INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu | Nowy Targ | Malopolskie |
| Poland | Medicus w Opolu Sp z o. o. | Opole | |
| Poland | Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota | Ostroda | |
| Poland | Medicome Sp. z o.o. | Oswiecim | |
| Poland | Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek | Piotrkow Trybunalski | Lodzkie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD" | Plock | Mazowieckie |
| Poland | Centrum Zdrowia Metabolicznego Pawel Bogdanski | Poznan | |
| Poland | Nzoz "Twoja Przychodnia" | Poznan | Wielkopolskie |
| Poland | Synexus Polska Sp. z o.o Oddzial w Poznaniu | Poznan | Wielkopolskie |
| Poland | KO-MED Centra Kliniczne Pulawy | Pulawy | Lubelskie |
| Poland | NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C. | Ruda Slaska | |
| Poland | Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, Poradnie Specjalistyczne, | Ruda Slaska | Slaskie |
| Poland | EMED Centrum Uslug Medycznych Ewa Smialek | Rzeszow | Podkarpackie |
| Poland | Centrum Medyczne Ogrodowa Sp. z o.o. | Skierniewice | Lodzkie |
| Poland | Centrum Medyczne "SOPMED" Sp. z o.o. | Sopot | Pomorskie |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka | Starogard Gdanski | Pomorskie |
| Poland | KO-MED Centra Kliniczne Staszow | Staszow | |
| Poland | Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka | Tarnow | Malopolskie |
| Poland | Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga | Tarnow | Malopolskie |
| Poland | Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie | Warszawa | Mazowieckie |
| Poland | Centrum Medyczne Piaski Filia Nr 9 | Warszawa | Mazowieckie |
| Poland | CSK MSW w Warszawie, Klinika Kardiologii Zachowawczej i Nadcisnienia Tetniczego | Warszawa | Mazowieckie |
| Poland | Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala | Warszawa | |
| Poland | Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warszawa | |
| Poland | Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warszawa | Mazowieckie |
| Poland | Instytut Kardiologii, Ii Klinika Choroby WieCowej | Warszawa | |
| Poland | Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. | Warszawa | Mazowieckie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Warszawie | Warszawa | |
| Poland | Wojskowy Instytut Medyczny, Klinika Kardiologii i Chorob Wewnetrznych, Centralny Szpital Kliniczny | Warszawa | Mazowieckie |
| Poland | Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski | Wloclawek | Kujawsko-pomorskie |
| Poland | NZOZ "Medyk"Sp. z o. o. | Wola | Slaskie |
| Poland | Dobrostan Michal Bogacki | Wroclaw | |
| Poland | Synexus Polska Sp. z o.o. Oddzial we Wroclawiu | Wroclaw | Dolnoslaskie |
| Poland | Wojewodzki Szpital Specjalistyczny we Wroclawiu, Osrodek Badawczo-Rozwojowy | Wroclaw | Dolnoslaskie |
| Poland | Zdrowie s.c. Agnieszka i Donald Drozdz | Wroclaw | Dolnoslaskie |
| Poland | KO-MED Centra Kliniczne Zamosc | Zamosc | Lubelskie |
| Poland | Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED | Zarow | Dolnoslaskie |
| Puerto Rico | The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC) | Anasco | |
| Puerto Rico | Cardiometabolic Research Center, Inc. | Ponce | |
| Puerto Rico | Endocrine Lipid Diabetes Research Institute | Ponce | |
| Puerto Rico | Altamira Family Medicine And Research Institute | San Juan | |
| Puerto Rico | Centro de Diabetes para Puerto Rico | San Juan | |
| Puerto Rico | Miguel Sosa-Padilla, MD-Private Practice | San Juan | |
| Puerto Rico | Pradnet Inc. | San Juan | |
| Romania | CMI Pop Calin Florin | Baia Mare | JUD Maramures |
| Romania | Dr. Pop Calin Florin - Cabinet Cardiologie | Baia Mare | Maramures |
| Romania | Euromedica Hospital | Baia Mare | |
| Romania | Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital) | Braila | |
| Romania | Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL, Medicina Interna | Brasov | |
| Romania | S.C. Polimed Dacia S.R.L. | Brasov | |
| Romania | "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, | Bucharest | |
| Romania | Clinica Medicala Synexus Ltd. | Bucharest | Sectorul 2 |
| Romania | Data Plus Medical Clinic | Bucharest | |
| Romania | Med Plus Srl | Bucharest | |
| Romania | Med Plus SRL (Med Plus Ltd.) | Bucharest | |
| Romania | S.C. Centrul Medical "Sanatatea Ta" S.R.L. | Bucharest | |
| Romania | SC Centrul Medical Policlinico Di Monza SRL, Cardiologie | Bucuresti | |
| Romania | SC Policlinica CCBR SRL | Bucuresti | |
| Romania | Spitalul Clinic Colentina, Departament Cardiologie | Bucuresti | |
| Romania | Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila | Bucuresti | |
| Romania | Spitalul Clinic Judetean De Urgenta Cluj-Napoca, Diabet Zabarat | Cluj-Napoca | |
| Romania | Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice | Cluj-Napoca | |
| Romania | County Emergency Hospital Deva | Deva | Hunedoara |
| Romania | Dr. Mistodie Cristina Victoria MD, Office of | Galati | |
| Romania | S.C. Diamed Obesity S.R.L. | Galati | |
| Romania | County Clinical Emergency Hospital Oradea | Oradea | Bihor |
| Romania | Medical Practice SRL | Oradea | Bihor |
| Romania | Pitesti-Arges County Emergency Hospital | Pitesti | Arges |
| Romania | Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice | Ploiesti | Prahova |
| Romania | Dr. Busegeanu Mihaela Private Practice | Ploiesti | Prahova |
| Romania | County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department | Satu Mare | |
| Romania | County Clinical Emergency Hospital Sibiu | Sibiu | |
| Romania | Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice | Targu Mures | Mures |
| Romania | Cardio Med SRL, Cardiologie | Tg. Mures | |
| Romania | Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat Nutritie si Boli Metabolice | Timisoara | Judet Timis |
| Romania | Centrul Medical Sf. Stefan | Timisoara | |
| Romania | Institute of Cardiovascular Diseases Timisoara | Timisoara | Timis |
| Romania | Institution Centrul Medical Sf. Stefan SRL, Diabet Nutritie si Boli Metabolice | Timisoara | |
| Russian Federation | Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6" | Chelyabinsk | |
| Russian Federation | Non-State Institution of Healthcare | Chelyabinsk | |
| Russian Federation | State Budgetary Healthcare Institution ¿Region Clinical Hospital #3¿ | Chelyabinsk | |
| Russian Federation | Municipal Autonomous Institution "City Clinical Hospital #14" | Ekaterinburg | |
| Russian Federation | Regional Budgetary Healthcare Institution "Cardiology Dispensary" | Ivanovo | |
| Russian Federation | State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital" | Kaluga | |
| Russian Federation | Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University" | Kazan | |
| Russian Federation | FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2 | Kazan | Tatarstan Republic |
| Russian Federation | State Autonomous Healthcare Institution "Republic Clinical Hospital" | Kazan | |
| Russian Federation | "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """ | Kemerovo | |
| Russian Federation | FSBI "Research institute of complex problems of cardio-vascular diseases" of | Kemerovo | |
| Russian Federation | FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across | Kemerovo | |
| Russian Federation | Municipal Budgetary Institution of Healthcare Municipal Clinical Hospital #3 n.a. M.A. Podgorbunsky | Kemerovo | |
| Russian Federation | Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1" | Kirov | |
| Russian Federation | State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1 | Krasnodar | Krasnodar Region |
| Russian Federation | Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital" | Kursk | |
| Russian Federation | State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2" | Lubertsy | Moscow Region |
| Russian Federation | "Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of | Moscow | |
| Russian Federation | Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, President's | Moscow | |
| Russian Federation | Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic" | Moscow | |
| Russian Federation | Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin" | Moscow | |
| Russian Federation | Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD" | Moscow | |
| Russian Federation | SBHI Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" of Moscow Healthcare Department | Moscow | |
| Russian Federation | State Budget Institution of Healthcare (SBIH) of Moscow "City Clinical Hospital #81 | Moscow | |
| Russian Federation | State Regional Budgetary Healthcare Institution | Murmansk | |
| Russian Federation | State Budgetary Healthcare Institution of Nizhegorodskaya Region | Nizhniy Novgorod | |
| Russian Federation | "Reafan" LLC | Novosibirsk | |
| Russian Federation | Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine" | Novosibirsk | |
| Russian Federation | Municipal Budgetary Institution of Healthcare of Novosibirsk | Novosibirsk | |
| Russian Federation | State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency | Novosibirsk | |
| Russian Federation | State Budgetary Healthcare Institution (SBHI) N.N. Burdenko Regional Clinical Hospital of Penza | Penza | |
| Russian Federation | SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko" | Pushkin | |
| Russian Federation | State Budgetary Educational Institution Of Higher Professional Education | Rostov-on-Don | |
| Russian Federation | State Budgetary Educational Institution of Higher Professional Education | Rostov-on-Don | |
| Russian Federation | State Budgetary Institution "Ryazan Regional Clinical Hospital" | Ryazan | |
| Russian Federation | Federal State Budgetary Institution "Federal Almazov Medical Research Centre" of | Saint Petersburg | |
| Russian Federation | Limited Liability Company "Reavita" | Saint Petersburg | |
| Russian Federation | LLC "Institution of medical studies" | Saint Petersburg | |
| Russian Federation | Limited Liability Company International Medical Centre SOGAZ | Saint-Petersberg | |
| Russian Federation | Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #26" | Saint-Petersburg | |
| Russian Federation | SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF | Saint-Petersburg | |
| Russian Federation | State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary" | Samara | |
| Russian Federation | MHI "City Clinical Hospital 12"of the Healthcare Committee of | Saratov | |
| Russian Federation | State Institution of Healthcare "Regional Clinical Hospital" | Saratov | |
| Russian Federation | 1st Pavlov State Medical University of St. Petersburg | St. Petersburg | Sankt-peterburg |
| Russian Federation | Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First | St. Petersburg | |
| Russian Federation | Saint Petersburg State Budgetary Institution of Healthcare | St. Petersburg | Sestroretsk |
| Russian Federation | State Budgetary Educational Institution of Highest Professional Education | Tomsk | |
| Russian Federation | Tyumen Cardiology Research Center-branch of the Tomsk NRMC | Tomsk | |
| Russian Federation | Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences | Troitsk | Moscow Region |
| Russian Federation | "Tyumen Cardiology Center" Affiliate of the FSBSI "Scientific and Research Institution of Cardiology | Tyumen | |
| Russian Federation | State Autonomous Healthcare Institution of Tyumen region "Scientific-Practical Medical Center" | Tyumen | |
| Russian Federation | FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation based on Clinical | Yaroslavl | |
| Russian Federation | State Autonomous Healthcare Institution of Yaroslavl Region | Yaroslavl | |
| Russian Federation | State Autonomous Healthcare Institution of Yaroslavl region Clinical Emergency Hospital n.a..N.V.So | Yaroslavl | |
| Russian Federation | State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10" | Yaroslavl | |
| Russian Federation | State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8" | Yaroslavl | |
| Slovakia | Fakultna nemocnica F. D. Roosevelta | Banska Bystrica | |
| Slovakia | Stredoslovensky ustav srdcovych a cievnych chorob a.s. | Banska Bystrica | |
| Slovakia | Alian s.r.o., kardiologicka ambulancia | Bardejov | |
| Slovakia | KARDIO-SANUS spol. s.r.o. | Bratislava | |
| Slovakia | KARDIO-SANUS spol.,s.r.o.,Kardiologicka, interna a sonograficka ambulancia | Bratislava | |
| Slovakia | Kardiovaskularne Centrum S.R.O. | Bratislava | |
| Slovakia | Metabol KLINIK s.r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy | Bratislava | |
| Slovakia | Metabolicke Centrum MUDr. Katariny Raslovej, S.R.O. | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | |
| Slovakia | Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB) | Bratislava | Bratislavsky |
| Slovakia | UN Bratislava Nemocnica Sv.Cyrila a Metoda, kardiologicka ambulancia 1 | Bratislava | |
| Slovakia | UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava | Bratislava | |
| Slovakia | Univerzitna nemocnica Bmtislava, Nemocnica Stare Mesto | Bratislava | |
| Slovakia | Univerzitna Nemocnica Bratislava | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika | Bratislava | |
| Slovakia | VERIA, s.r.o. -Kardiologicka ambulancia | Bratislava | |
| Slovakia | Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia | Dolny Kubin | |
| Slovakia | JM-Interna s.r.o., interna ambulancia | Dolny Kubin | |
| Slovakia | AGTO., spol. s r. o. | Kosice | |
| Slovakia | CARDIO D&R s.r.o., Kardiologicka ambulancia | Kosice | |
| Slovakia | Cardio D&R spol.s.r.o., kardiologicka ambulancia | Kosice | |
| Slovakia | Medicentrum Heart, Spol. S.R.O | Kralovsky Chlmec | |
| Slovakia | CELL-B s.r.o. interna ambulancia | Levice | |
| Slovakia | Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas | Liptovsky Mikulas | |
| Slovakia | Narodny Endokrinologicky A Diabetologicky Ustav N.O. | Lubochna | |
| Slovakia | KARDIO 1 s.r.o. | Lucenec | |
| Slovakia | Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin | Martin | |
| Slovakia | MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva | Moldava nad Bodvou | |
| Slovakia | MUDr. Kanderkova s.r.o., Diabetologicka ambulancia | Namestovo | |
| Slovakia | Kardiocentrum Nitra s.r.o., kardiologicka ambulancia | Nitra | |
| Slovakia | Fakultna nemocnica s poliklinikou Nove Zamky, I. interna klinika | Nove Zamky | |
| Slovakia | Mediab s.r.o. Diabetologicka ambulancia | Pezinok | |
| Slovakia | BENIMED s.r.o. | Piestany | |
| Slovakia | Medispol S.R.O. | Presov | |
| Slovakia | Kardioamb S.R.O. | Rimavska Sobota | |
| Slovakia | Medilex s.r.o. Interna ambulancia | Rimavska Sobota | |
| Slovakia | DIAMEL, s.r.o., Diabetologicka ambulancia | Trencin | |
| Slovakia | BV Medical, s.r.o. Diabetologicka ambulancia, | Trnava | |
| Slovakia | Kardiologicka ambulancia | Trnava | |
| Slovakia | Medivasa S.R.O., Diabetologicka Ambulancia | Zilina | |
| South Africa | IATROS International | Bloemfontein | FREE State |
| South Africa | JOSHA Research | Bloemfontein | FREE State |
| South Africa | Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic | Cape Town | Western CAPE |
| South Africa | Synopsis Research cc | Cape Town | Western CAPE |
| South Africa | Tiervlei Trial Centre | Cape Town | Western CAPE |
| South Africa | Unitas Hospital. | Centurion | |
| South Africa | Dr Ganesh c/o Dr NB Maharaj | Durban | Kwazulu-natal |
| South Africa | Suite 502 | Durban | Kwazulu-natal |
| South Africa | Clinresco Centres (Pty) Ltd-Central Professional Suits | Gauteng | |
| South Africa | Midrand Medical Centre | Halfway House | Gauteng |
| South Africa | Centre for Diabetes and Endocrinology | Houghton | Gauteng |
| South Africa | Sunninghill Hospital | Johannesburg | Gauteng |
| South Africa | I Engelbrecht Research (Pty) Ltd | Lyttelton | Gauteng |
| South Africa | Nash Ranjith Research Centre | Merebank, Durban | KWA ZULU Natal |
| South Africa | Zinakekele Medical Centre | Moloto | Mpumalanga |
| South Africa | Paarl Research Centre | Paarl | |
| South Africa | Charlotte Maxeke Johannesburg Academic Hospital | Parktown | Gauteng |
| South Africa | TREAD Research cc | Parow | |
| South Africa | Medipark Centre for Clinical Research | Pretoria | Gauteng |
| South Africa | Synexus Watermeyer Clinical Research Centre | Pretoria | Gauteng |
| South Africa | Jongaie Research | Pretoria West | Gauteng |
| South Africa | Roodepoort Medicross Clinical Research Centre | Roodepoort | Gauteng |
| South Africa | Helderberg Research Institute | Somerset West | Western CAPE |
| South Africa | Synexus Helderberg Clinical Research Centre | Somerset West | Western CAPE |
| South Africa | Vergelegen Mediclinic-Helderberg Research Institute | Somerset West | Western CAPE |
| South Africa | Wits Clinical Research-Chris Hani Baragwanath Hospital | Soweto | Gauteng |
| South Africa | Medi-Clinic Heart Hospital | Sunnyside | Gauteng |
| South Africa | Limpopo Clinical Research Initiative | Thabazimbi | Limpopo |
| South Africa | Welkom Clinical Trial Centre | Welkom | FREE State |
| South Africa | Drs Joynt Venter & Associates | Witbank (eMalahleni) | Mpumalanga |
| South Africa | Clinical Projects Research SA (Pty) Ltd | Worcester | |
| Spain | Gerencia de Gestion integrada de A Coruna | A Coruna | |
| Spain | Complejo Hospitalario Universitario de Albacete | Albacete | |
| Spain | Hospital Virgen De Los Lirios | Alcoy | Alicante |
| Spain | Hospital General Universitario de Alicante; Servicio Cardiologia | Alicante | |
| Spain | Hospital Universitario San Juan de Alicante | Alicante | Comunidad Valenciana |
| Spain | Hospital Virgen del Mar | Almeria | |
| Spain | Hospital Universitario de Cruces | Barakaldo | PAIS Vasco |
| Spain | CAP Amadeu Torner | Barcelona | |
| Spain | CAP Centelles | Barcelona | |
| Spain | Centre Teknon | Barcelona | |
| Spain | EAP Sardenya | Barcelona | |
| Spain | Fundacio Hospital de I'Esperit Sant | Barcelona | |
| Spain | Hospital de la Santa Creu i Sant Pau | Barcelona | |
| Spain | Hospital Universitari Vall d'Hebron | Barcelona | |
| Spain | Hospital Universitario de Bellvitge | Barcelona | |
| Spain | Parc de Salut mar ¿ Hospital del Mar | Barcelona | |
| Spain | Parc de Salut Mar- Hospital del Mar | Barcelona | |
| Spain | Hospital Universitario Reina Sofia | Cordoba | |
| Spain | Hospital Arquitecto Marcide | El Ferrol | LA Coruna |
| Spain | CAP Disset De Setembre (Sant Cosme I Sant Damia) | El Prat De Llobregat | Barcelona/cataluna |
| Spain | Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol | Ferrol | |
| Spain | Hospital De Figueres | Figueres | Girona-catalonia |
| Spain | Hospital Universitario San Cecilio | Granada | |
| Spain | Hospital Universitario Virgen de las Nieves (HUVN) | Granada | |
| Spain | Hospital Comarcal d'Inca | Inca | Illes Balears |
| Spain | Cap Florida | L'Hospitalet De Llobregat | Barcelona-cataluna |
| Spain | Hospital Universitari de Bellvitge | L'Hospitalet de Llobregat | Barcelona |
| Spain | Hospital Universitari Arnau de Vilanova | Lleida | |
| Spain | Hospital Universitari Arnau de Vilanova (HUAV) | Lleida | |
| Spain | Pharmacy - Hospital Universitari Arnau de Vilanova (HUAV) | Lleida | |
| Spain | Hospital Universitario Lucus Augusti | Lugo | |
| Spain | Carretera Alcala-Meco s/n | Madrid | |
| Spain | Fundacion Jimenez Diaz | Madrid | |
| Spain | H. U. Principe de Asturias | Madrid | |
| Spain | Hospital Carlos III | Madrid | |
| Spain | Hospital General Universitario Gregorio Maranon | Madrid | |
| Spain | Hospital Universitario de La Princesa | Madrid | |
| Spain | Hospital Universitario Fundacion Jimenez Diaz | Madrid | |
| Spain | Hospital Universitario Infanta Sofía | Madrid | |
| Spain | Hospital Universitario La Paz; Unidad Metabolico-Vascular | Madrid | |
| Spain | Hospital Universitario Ramon y Cajal | Madrid | |
| Spain | Hospital Hospital Universitario Puerta de Hierro - Majadahonda | Majadahonda | Madrid |
| Spain | Hospital Regional Universitario de Malaga | Malaga | Andalucia |
| Spain | Hospital Regional Universitario de Malaga | Malaga | |
| Spain | Hospital Universitario Virgen De La Victoria | Malaga | |
| Spain | Hospital Universitario Virgen de la Victoria. CE San Jose Obrero | Malaga | |
| Spain | Hospital General Universitario Morales Meseguer | Murcia | |
| Spain | Centro de Salud El Cristo | Oviedo | Asturias |
| Spain | Centro Salud Paulino Prieto | Oviedo | Asturias |
| Spain | Albera Salut | Peralada | Gerona |
| Spain | Hospital Universitario Quiron Madrid | Pozuelo de Alarcon | Madrid |
| Spain | Hospital General De Requena | Requena | Valencia |
| Spain | Hospital Universitario Sant Joan de Reus | Reus | Tarragona |
| Spain | Hospital Universitario Sant Joan de Reus | Reus (Tarragona) | |
| Spain | Hospital Santa Caterina | Salt, Girona | Girona |
| Spain | CAP La Mina | Sant Adria De Besos | Barcelona |
| Spain | Hospital Universitario Marques De Valdecilla | Santander | Cantabria |
| Spain | Hospital Clinico Universitario de Santiago de Compostela | Santiago de Compostela | A Coruna |
| Spain | Clinica Nuevas Tecnologias En Diabetes Y Endocrinologia | Sevilla | |
| Spain | Hospital Universitario Virgen de Valme | Sevilla | |
| Spain | Hospital Universitario Virgen del Rocio | Sevilla | Andalucia |
| Spain | Hospital Universitario Virgen Macarena | Sevilla | |
| Spain | CAP Muralles | Tarragona | |
| Spain | Hospital Universitari de Tarragona Joan XXIII | Tarragona | Catalonia |
| Spain | Hospital General Universitario de Valencia | Valencia | |
| Spain | EAP Vic | Vic | Barcelona |
| Spain | Hospital Clinico Universitario Miguel Servet; Medicina Interna | Zaragoza | |
| Sweden | Kasernens Läkarservice AB | Eksjö | |
| Sweden | Sahlgrenska Universitetssjukhuset | Goteborg | |
| Sweden | Pharmasite AB | Helsingborg | |
| Sweden | Medicinklinikens forskningsenhet | Kristianstad | |
| Sweden | Hjartmottagningen, Capio Citykliniken | Lund | |
| Sweden | Probar E Lund AB | Lund | |
| Sweden | Karlkliniken, Skanes Universitetssjukhus i Malmo | Malmo | |
| Sweden | Pharmasite AB | Malmo | |
| Sweden | Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J | Molndal | |
| Sweden | Ostersunds Sjukhus | Ostersund | |
| Sweden | Dalecarlia Clinical Research Center | Rattvik | |
| Sweden | Skelleftea Lasarett | Skelleftea | |
| Sweden | A+Science City site | Stockholm | |
| Sweden | Hjartkliniken | Stockholm | |
| Sweden | Karolinska Universitetssjukhuset | Stockholm | |
| Sweden | Karolinska universitetssjukhuset Huddinge | Stockholm | Huddinge |
| Sweden | Akademiska Sjukhuset | Uppsala | |
| Sweden | Vastmanlands Sjukhus Vasteras | Vasteras | |
| Switzerland | Universitatsspital | Basel | Basel Stadt |
| Switzerland | Hospitaux Universitaires de Geneve (HUG) | Geneve | Geneva |
| Switzerland | Centre Hospitalier Universitaire Vaudois | Lausanne | |
| Switzerland | Policlinique Medicale Universitaire | Lausanne | Vaud |
| Switzerland | Cardiocentro Ticino | Lugano | |
| Switzerland | Fondazione Diabete Lugano | Lugano | |
| Switzerland | Luzerner Kantonsspital Luzern | Luzern 16 | |
| Switzerland | Diagene Laboratories Inc. | Reinach | Basel |
| Switzerland | Kantonsspital St. Gallen | St. Gallen | |
| Switzerland | Kantonsspital Winterthur | Winterthur | Zurich |
| Taiwan | Kaohsiung Medical University Chung-Ho Memorial Hospital - New | Kaohsiung | |
| Taiwan | Cardinal Tien Hospital | New Taipei City | |
| Taiwan | China Medical University Hospital | Taichung | Taiwan R O C |
| Taiwan | Chung Shan Medical University Hospital | Taichung | |
| Taiwan | National Cheng Kung University (NCKU) Hospital | Tainan | |
| * Note: There are 1596 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| Pfizer |
United States, Argentina, Australia, Belgium, Brazil, Canada, Chile, Colombia, Czechia, Denmark, Finland, France, Germany, Hungary, India, Ireland, Israel, Italy, Korea, Republic of, Mexico, Netherlands, New Zealand, Poland, Puerto Rico, Romania, Russian Federation, Slovakia, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, Turkey, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Event Rate Per 100 Participant-years for First Occurrence of Major Cardiovascular (CV) Event | Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death [defined as sudden cardiac death, fatal myocardial infarction (MI), death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes] non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infraction (MI) or Non-fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of CV Death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infraction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of All-cause Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke or Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of composite endpoint of CV death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of CV death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for Cardiovascular (CV) Death | Event rate per 100 participant-years for occurrence of CV death (adjudicated by Adjudication Committee) was reported. CV death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other CV causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of CV death (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Any Myocardial Infarction (Fatal or Non-fatal) | Event rate per 100 participant-years for first occurrence of any myocardial infarction (fatal or non-fatal) (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any myocardial infarction (fatal or non-fatal) (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for Fatal Myocardial Infarction (MI) | Event rate per 100 participant-years for occurrence of fatal MI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Myocardial Infarction (MI) | Event rate per 100 participant-years for first occurrence of non-fatal MI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal) | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Any Stroke (Fatal or Non-fatal), of Any Etiology | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) of any etiology (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) of any etiology (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for Fatal Stroke | Event rate per 100 participant-years for occurrence of fatal stroke (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Non-fatal Stroke | Event rate per 100 participant-years for first occurrence of non-fatal stroke (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Hospitalization for Congestive Heart Failure (CHF) | Event rate per 100 participant-years for first occurrence of hospitalization for CHF (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for CHF (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Coronary Revascularization | Event rate per 100 participant-years for first occurrence of coronary revascularization (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Coronary Artery Bypass Graft Surgery (CABG) | Event rate per 100 participant-years for first occurrence of CABG (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Percutaneous Coronary Intervention (PCI) | Event rate per 100 participant-years for first occurrence of PCI (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for First Occurrence of Any Arterial Revascularizations | Event rate per 100 participant-years for first occurrence of any arterial revascularizations (adjudicated by Adjudication Committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-years for All-cause Death | Event rate per 100 participant-years for occurrence of all-cause death (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years) | |
| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14 | Baseline, Week 14 | ||
| Secondary | Nominal Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 14 | Baseline, Week 14 | ||
| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Last Post-baseline Measurement | Baseline, last post-baseline measurement (any time up to Week 140) | ||
| Secondary | Percent Change From Baseline in Lipid Levels at Week 14 | Lipids included non-high density lipoprotein cholesterol (non-HDL-C), very low density lipoprotein cholesterol (VLDL-C), remnant lipoprotein cholesterol (RLP-C), apolipoprotein B (Apo B), HDL-C, apolipoprotein A-I (Apo A-I) and total cholesterol. | Baseline, Week 14 | |
| Secondary | Percent Change From Baseline in Log-transformed Triglycerides and Lipoprotein (a) (Lp[a]) at Week 14 | Baseline, Week 14 | ||
| Secondary | Percent Change From Baseline in Log-transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14 | Baseline, Week 14 |
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