Cardiovascular Disease Clinical Trial
— SPIRE-1Official title:
Phase 3 Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615) In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects.
| Verified date | June 2018 |
| Source | Pfizer |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization, in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 70 mg/dL (1.8 mmol/L) or non-HDL-C >/= 100 mg /dL (2.6 mmol/L).
| Status | Terminated |
| Enrollment | 16784 |
| Est. completion date | March 22, 2017 |
| Est. primary completion date | March 22, 2017 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Must be on background lipid lowering treatment. - Must be at high risk of a CV event. - Must have an LDL C >/=70 mg/dL (1.8 mmol/L) or non-HDL-C >/= 100 mg/dL (2.6 mmol/L). Exclusion Criteria: - Planned coronary (PCI or CABG) or other arterial revascularization. - New York Heart Association Class IV congestive heart failure or left ventricular ejection fraction < 25% by cardiac imaging. - Chronic renal insufficiency with creatinine clearance of <30 ml/min/1.73m^2 by MDRD formula or with end state renal disease on dialysis. - History of hemorrhagic stroke. - Prior exposure to bococizumab or other investigational PCSK9 inhibitor. |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Hospital Interzonal Gral. de Agudos Dr. Jose Penna | Bahia Blanca | PCIA DE Buenos Aires |
| Argentina | Hospital Italiano Regional del Sur | Bahia Blanca | Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca | Buenos Aires |
| Argentina | Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada | C.a.b.a | C.a.b.a. |
| Argentina | STAT Research S.A. | C.a.b.a | Caba |
| Argentina | CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A. | C.a.b.a. | |
| Argentina | Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L. | Ciudad Autonoma De B. Aires | |
| Argentina | Hospital Britanico De Buenos Aires | Ciudad Autonoma de B. Aires | Buenos Aires |
| Argentina | Instituto Cardiovascular De Buenos Aires | Ciudad Autonoma de B. Aires | |
| Argentina | Instituto de Cardiologia y Cirugia Cardiovascular - Fundacion Favaloro | Ciudad Autonoma de B. Aires | |
| Argentina | CEDIC - Consultorios Medicos | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Centro de Investigacion: AXISMED S.R.L. | Ciudad Autonoma de Buenos Aires | |
| Argentina | Investigaciones Medicas IMOBA S.R.L. | Ciudad Autonoma de Buenos Aires | |
| Argentina | Universidad Maimonides | Ciudad Autonoma De Buenos Aires | |
| Argentina | IMEP Instituto Medico Elsa Perez | Ciudadela | PCIA DE Buenos Aires |
| Argentina | Centro de Investigaciones Clinicas "Instituto del Corazon" | Cordoba | |
| Argentina | Centro Medico Luquez | Cordoba | |
| Argentina | Clinica Privada Colombo | Cordoba | |
| Argentina | Clinico Chutro SRL | Cordoba | |
| Argentina | ILAIM Instituto Latinoamericano de Investigaciones Medicas | Cordoba | |
| Argentina | Instituto Medico DAMIC S.R.L. | Cordoba | |
| Argentina | IPAC Caraffa | Cordoba | |
| Argentina | Clinica Coronel Suarez S.A. | Coronel Suarez | Provincia DE Buenos Aires |
| Argentina | Instituto de Cardiologia de Corrientes "Juana Fca. Cabral" | Corrientes | |
| Argentina | Hospital de Alta Complejidad "Pte. Juan Domingo Peron" | Formosa | PCIA DE Formosa |
| Argentina | CIPADI Centro Integral de Prevencion y Atencion en Diabetes | Godoy Cruz | Mendoza |
| Argentina | Framingham Centro Medico | La Plata | Buenos Aires |
| Argentina | CIMeL CHAHIN CHAHIN S.A. | Lanus Este | Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas Mar del Plata | Mar del Plata | Buenos Aires |
| Argentina | Hospital Central de Mendoza | Mendoza | |
| Argentina | Instituto Medico Aguero | Moron | PCIA DE Buenos Aires |
| Argentina | Instituto de Investigaciones Clinicas Quilmes | Quilmes | Buenos Aires |
| Argentina | DIM Clinica Privada | Ramos Mejia | Buenos Aires |
| Argentina | Cordis - Instituto del Corazon | Resistencia | PCIA DE Chaco |
| Argentina | Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli" | Rosario | Pcia. DE Santa FE |
| Argentina | Instituto de Investigaciones Clinicas Rosario | Rosario | Santa FE |
| Argentina | Instituto Medico CENICLAR - Central de Investigaciones Clinicas Argentina -Sanatorio de la Mujer | Rosario | Provincia DE Santa FE |
| Argentina | Centro Cardiovascular Salta | Salta | |
| Argentina | Cordis S.A. | Salta | |
| Argentina | Instituto Cardiovascular San Luis A.E. | San Luis | |
| Argentina | Corporacion Medica de San Martin | San Martin | PCIA DE Buenos Aires |
| Argentina | Centro Medico CCBR Tucuman | San Miguel de Tucuman | Tucuman |
| Argentina | Centro Modelo de Cardiologia | San Miguel De Tucuman | PCIA DE Tucuman |
| Argentina | Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A. | Santa Fe | PCIA DE Santa FE |
| Argentina | Centro De Investigaciones Clinicas Del Litoral S.R.L. | Santa Fe | PCIA DE Santa FE |
| Argentina | Hospital Provincial Dr. Jose Maria Cullen | Santa Fe | PCIA DE Santa FE |
| Argentina | Clinica Privada de Especialidades Medicas | Villa Maria | Cordoba |
| Argentina | Instituto de Investigaciones Clinicas Zarate | Zarate | Buenos Aires |
| Australia | Adelaide Medical Research | Ashford | South Australia |
| Australia | SA Heart | Ashford | South Australia |
| Australia | Eastern Health - Box Hill Hospital | Box Hill | Victoria |
| Australia | Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders | Camperdown | New South Wales |
| Australia | Royal Prince Alfred Hospital | Camperdown | New South Wales |
| Australia | Holy Spirit Northside Private Hospital Limited | Chermside | Queensland |
| Australia | Southern Adelaide Diabetes and Endocrine Service | Daws Park | South Australia |
| Australia | Department of Cardiology, Lyell McEwin Hospital | Elizabeth Vale | South Australia |
| Australia | The Northern Hospital | Epping | Victoria |
| Australia | Central Coast Neurosciences Research | Erina | New South Wales |
| Australia | Fremantle Hospital | Fremantle | Western Australia |
| Australia | Heart and Vascular Research | Fullarton | South Australia |
| Australia | Canberra Hospital | Garran | Australian Capital Territory |
| Australia | Barwon Health-The Geelong Hospital | Geelong | Victoria |
| Australia | Gosford Hospital | Gosford | New South Wales |
| Australia | Austin Health - Heidelberg Repatriation Hospital | Heidelberg West | Victoria |
| Australia | Royal Brisbane and Women's Hospital | Herston | Queensland |
| Australia | HPS Pharmacies | Joondalup | Western Australia |
| Australia | Joondalup Cardiovascular Trials Foundation Inc. | Joondalup | Western Australia |
| Australia | Launceston General Hospital | Launceston | Tasmania |
| Australia | Australian Clinical Research Network | Maroubra | New South Wales |
| Australia | Alfred Hospital | Melbourne | Victoria |
| Australia | Core Research Group Pty Ltd | Milton | Queensland |
| Australia | Sir Charles Gairdner Hospital, Heart Research Institute | Nedlands | Western Australia |
| Australia | Royal Melbourne Hospital | Parkville | Victoria |
| Australia | Redcliffe Hospital | Redcliffe | Queensland |
| Australia | Austrials Pty Ltd | Sherwood | Queensland |
| Australia | Gold Coast University Hospital | Southport | Queensland |
| Australia | Royal North Shore Hospital | St Leonards | New South Wales |
| Belgium | Algemeen Stedelijk Ziekenhuis | Aalst | Oost-vlaanderen |
| Belgium | Hopital Erasme-Universite Libre de Bruxelles (ULB) | Anderlecht | Brabant Flamand |
| Belgium | ZNA Campus Middelheim | Antwerpen | |
| Belgium | Imeldaziekenhuis Bonheiden | Bonheiden | |
| Belgium | VZW Algemeen Ziekenhuis KLINA | Brasschaat | Antwerpen |
| Belgium | A.Z. St.Jan AV Brugge | Brugge | |
| Belgium | University Hospital Brussels - Centrum voor hart- en vaatziekten | Brussels | |
| Belgium | University Hospital Brussels- Diabeteskliniek | Brussels | |
| Belgium | Private Practice 'Cardiovascular Detection Center' | De Pinte | |
| Belgium | Az Sint Blasius | Dendermonde | Oost-vlaanderen |
| Belgium | ZOL Campus Sint-Jan | Genk | |
| Belgium | AZ Maria Middelares | Gent | |
| Belgium | AZ Sint Lucas Gent-Campus Sint Lucas | Gent | Oost-vlaanderen |
| Belgium | Grand Hopital de Charleroi, Site St-Joseph | Gilly | |
| Belgium | Hygeia | Hasselt | |
| Belgium | Jessa Ziekenhuis | Hasselt | |
| Belgium | Sint-Franciskusziekenhuis | Heusden-Zolder | |
| Belgium | Centre Hospitalier Regional de Huy | Huy | |
| Belgium | Jan Yperman Ziekenhuis, Cardiology | Ieper | |
| Belgium | AZ Groeninge-Campus Loofstraat | Kortrijk | West-vlaanderen |
| Belgium | Centre hospitalier de Jolimont-Lobbes - Centre de Recherche Medicale de Jolimont | La Louviere | Haine Saint PAUL |
| Belgium | Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven | |
| Belgium | University hospitals Leuven - Cardiology department | Leuven | |
| Belgium | Centre Hospitalier Chretien | Liege | |
| Belgium | Centre Hospitalier Universitaire de Liege | Liege | |
| Belgium | Huisartsenpraktijk Medilink | Linkebeek | |
| Belgium | Huisartsenpraktijk Luc Capiau | Massemen | |
| Belgium | AZ Sint-Maarten | Mechelen | |
| Belgium | C.H.U. Ambroise Pare | Mons | |
| Belgium | Az Damiaan | Oostende | West-vlaanderen |
| Belgium | Mariaziekenhuis vzw | Overpelt | |
| Belgium | Az Glorieux | Ronse | Oost-vlaanderen |
| Belgium | AZ Nikolaas | Sint-Niklaas | |
| Belgium | Dr. Luc De Wolf - Private Practice | Tienen | |
| Belgium | AZ Turnhout - campus St. Elisabeth | Turnhout | Antwerpen |
| Belgium | A.Z. Sint-Augustinus Veurne | Veurne | West-vlaanderen |
| Brazil | Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto | Belem | PA |
| Brazil | CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA | Belo Horizonte | Minas Gerais |
| Brazil | Hospital Felicio Rocho | Belo Horizonte | MG |
| Brazil | Hospital Lifecenter / Lifecenter Sistema de Saude S.A | Belo Horizonte | MG |
| Brazil | Hospital Universitario Ciencias Medicas / Fundacao Educacional Lucas Machado | Belo Horizonte | Minas Gerais |
| Brazil | Hospital Universitário Sao José / FELUMA - MG | Belo Horizonte | MG |
| Brazil | Hospital Vera Cruz | Belo Horizonte | Minas Gerais |
| Brazil | Liga Mineira de Ressucitacao cardiopulmonar | Belo Horizonte | Minas Gerais |
| Brazil | Liga Mineira de Ressuscitacao Cardiopulmonar | Belo Horizonte | Minas Gerais |
| Brazil | Hospital Santa Isabel | Blumenau | Santa Catarina |
| Brazil | Instituto De Cardiologia Do Distrito Federal | Brasilia | Distrito Federal |
| Brazil | Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron | Campina Grande do Sul | PR |
| Brazil | CAEP - Centro Avançado de Estudos e Pesquisas Ltda. | Campinas | SP |
| Brazil | Hospital E Maternidade Celso Pierro PUC - Campinas - Sociedade Campineira de Educacao e Instrucao | Campinas | SAO Paulo |
| Brazil | Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda | Campinas | SAO Paulo |
| Brazil | Scentryphar Pesquisa Clinica | Campinas | SAO Paulo |
| Brazil | Hospital Universitario - Associacao Educadora Sao Carlos - AESC | Canoas | RIO Grande DO SUL |
| Brazil | Hospital Santa Casa De Curitiba | Curitiba | Parana |
| Brazil | Irmandade da Santa Casa de Misericordia de Curitiba - Hospital Santa Casa de Misericordia | Curitiba | PR |
| Brazil | Nucleo de Pesquisa Clínica | Curitiba | Parana |
| Brazil | Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV | Curitiba | PR |
| Brazil | Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda | Fortaleza | CE |
| Brazil | Hospital de Messejana Dr Carlos Alberto Studart Gomes | Fortaleza | Ceara |
| Brazil | Hospital Universitario Walter Cantidio | Fortaleza | Ceara |
| Brazil | INGOH - Instituto Goiano de Oncologia e Hematologia | Goiania | Goias |
| Brazil | Via Medica - Clinica Medica Integrada Ltda - Barroso e Sebba Ltda | Goiania | GO |
| Brazil | ICM - Instituto do Coracao de Marilia | Marilia | SAO Paulo |
| Brazil | Hospital Parana - Parana Medical Research Center - MARIMED SERVICOS MEDICOS S.A. | Maringa | Parana |
| Brazil | Hemocardio S/S Ltda | Natal | RN |
| Brazil | Instituto Conceive | Paraiso | SAO Paulo |
| Brazil | Associacao Hospitalar Beneficente Sao Vicente de Paulo - Hospital Sao Vicente de Paulo | Passo Fundo | RS |
| Brazil | Santa Casa De Misericordia De Pelotas | Pelotas | RIO Grande DO SUL |
| Brazil | Hospital de Clinicas de Porto Alegre | Porto Alegre | RIO Grande DO SUL |
| Brazil | Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC/IMV - Instituto de Medicina Vascular | Porto Alegre | RIO Grande DO SUL |
| Brazil | Irmandade Da Santa Casa De Misericordia De Porto Alegre - ISCMPA | Porto Alegre | RS |
| Brazil | Uniao Brasileira de Educacao e Assistencia (UBEA) - Hospital Sao Lucas da PUCRS | Porto Alegre | RS |
| Brazil | Centro de Pesquisas Medicas Basica e Clinica LTDA | Recife | PE |
| Brazil | Hospital Agamenon Magalhaes | Recife | Pernambuco |
| Brazil | CCBR - Centro de Pesquisas e Analises Clinicas LTDA | Rio De Janeiro | RJ |
| Brazil | CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA | Rio de Janeiro | RJ |
| Brazil | Fundacao Bahiana De Cardiologia | Salvador | BA |
| Brazil | HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia | Salvador | BA |
| Brazil | Instituto Cardiopulmonar da Bahia | Salvador | Bahia |
| Brazil | Hospital Estadual Mario Covas | Santo Andre | SAO Paulo |
| Brazil | Insituto de Cardiologia de Santa Catarina | Sao Jose | Santa Catarina |
| Brazil | Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto | Sao Jose do Rio Preto | SAO Paulo |
| Brazil | IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda | Sao Jose do Rio Preto | SAO Paulo |
| Brazil | Instituto Domingo Braile _ Braile Hospital Dia LTDA | Sao Jose Do Rio Preto | SAO Paulo |
| Brazil | CCBR Sao Paulo | Sao Paulo | SP |
| Brazil | CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda. | Sao Paulo | SP |
| Brazil | Comed Care Empresa de Atendimento Clinico Geral - LTDA - Hospital Total Care | Sao Paulo | SP |
| Brazil | CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz | Sao Paulo | |
| Brazil | CPQuali Pesquisa Clinica LTDA | Sao Paulo | SP |
| Brazil | FGM-Clinica Paulista de Doencas Cardiovasculares | Sao Paulo | |
| Brazil | Hospital Samaritano | Sao Paulo | SP |
| Brazil | Instituto de Conhecimento, Ensino e Pesquisa (Administrative local) | Sao Paulo | SP |
| Brazil | Instituto Jaqueline Scholz Issa e Mario Issa de Cardiologia LTDA | Sao Paulo | |
| Brazil | SPDM Associacao Paulista para o Desenvolvimento da Medicina | Sao Paulo | |
| Brazil | UNIFESP - Hospital Sao Paulo - Setor de Lipides, Aterosclerose e Biologia Vascular | Sao Paulo | |
| Brazil | Eurolatino Pesquisas Medicas LTDA | Uberlandia | Minas Gerais |
| Brazil | Universidade Federal de Uberlandia | Uberlandia | Minas Gerais |
| Brazil | CEDOES - Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo | Vitoria | Espirito Santo |
| Brazil | Santa Casa de Misericordia de Votuporanga | Votuporanga | SAO Paulo |
| Canada | LMC Diabetes & Endocrinology (Brampton) | Brampton | Ontario |
| Canada | Aviva Clinical Trial Group Inc. | Burlington | Ontario |
| Canada | JBN Medical Diagnostic Services Inc. | Burlington | Ontario |
| Canada | Philippe R. Beaudry Medicine Professional Corporation | Burlington | Ontario |
| Canada | Foothills Hospital/University of Calgary | Calgary | Alberta |
| Canada | LMC Diabetes & Endocrinology (Calgary) | Calgary | Alberta |
| Canada | Nanji Professional Corporation | Calgary | Alberta |
| Canada | Cambridge Cardiac Care Centre | Cambridge | Ontario |
| Canada | Vizel Cardiac Research, Saul Vizel Professional Medicine Corporation | Cambridge | Ontario |
| Canada | Ecogene-21 | Chicoutimi | Quebec |
| Canada | Q & T Research Chicoutimi | Chicoutimi | Quebec |
| Canada | Moran Medical Centre | Collingwood | Ontario |
| Canada | C & L Research | Fort Erie | Ontario |
| Canada | Q&T Recherche Outaouais Inc. | Gatineau | Quebec |
| Canada | Parkdale Medical Centre | Hamilton | Ontario |
| Canada | The Medical Arts Health Research Group | Kelowna | British Columbia |
| Canada | Centre de Recherche Clinique de Laval | Laval | Quebec |
| Canada | Stroke Prevention & Atherosclerosis Research Centre (SPARC)-Siebens-Drake Research Institute | London | Ontario |
| Canada | Western University - WCPHFM | London | Ontario |
| Canada | LMC Diabetes & Endocrinology (Markham) | Markham | Ontario |
| Canada | Omnispec clinical research inc | Mirabel | Quebec |
| Canada | G.A. Research Associates Ltd. | Moncton | New Brunswick |
| Canada | Diex Research Montreal, Inc. | Montreal | Quebec |
| Canada | Montreal Heart Institute | Montreal | Quebec |
| Canada | Newmarket Cardiology Research Group | Newmarket | Ontario |
| Canada | LMC Clinical Research Inc. (Oakville) | Oakville | Ontario |
| Canada | LMC Oakville | Oakville | Ontario |
| Canada | The Office of Dr. James Cha | Oshawa | Ontario |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Clinique des maladies lipidiques de Quebec | Quebec | |
| Canada | Recherche Clinique Sigma Inc | Quebec | |
| Canada | Cardiology Research Associates of New Brunswick | Saint John | New Brunswick |
| Canada | London Road Diagnostic Clinic and Medical Centre | Sarnia | Ontario |
| Canada | Sarnia Institute of Clinical Research | Sarnia | Ontario |
| Canada | Scarborough Cardiology Research Associates Inc. | Scarborough | Ontario |
| Canada | Centre Hospitalier Universitaire de Sherbrooke- Hotel-Dieu | Sherbrooke | Quebec |
| Canada | Canadian Centre for Research on Diabetes | Smiths Falls | Ontario |
| Canada | Centre integre de sante et de services sociaux de Lanaudiere (CISSSL) | St Charles-Borromee | Quebec |
| Canada | Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSS-CA) | St-Georges, Beauce | Quebec |
| Canada | CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche | St-Jerome | Quebec |
| Canada | St-Jerome Medical Research Inc. | St-Jerome | Quebec |
| Canada | Health Sciences Centre | St. John's | Newfoundland and Labrador |
| Canada | Brian Y.L. Wong Medicine Professional Corporation | Sudbury | Ontario |
| Canada | Dr Peter K.H. Tan Inc | Surrey | British Columbia |
| Canada | Dr Stephen Pearce Inc | Surrey | British Columbia |
| Canada | Dr. Adam Yeung Inc. | Surrey | British Columbia |
| Canada | Dr. Dante E. Manyari Inc. | Surrey | British Columbia |
| Canada | Dr. Kapil M. Bhagirath Medical Services Corporation | Surrey | British Columbia |
| Canada | Dr. Micheal Kanakos Inc | Surrey | British Columbia |
| Canada | Dr. Raymond Dong Inc. | Surrey | British Columbia |
| Canada | Dr. Richard Bon Inc. | Surrey | British Columbia |
| Canada | Dr. Stephanie Au, Inc. | Surrey | British Columbia |
| Canada | Dr. Stephen S. Cheung Inc. | Surrey | British Columbia |
| Canada | SMH Cardiology Clinical Trials | Surrey | British Columbia |
| Canada | SMH Cardiology Clinical Trials Inc. | Surrey | British Columbia |
| Canada | LMC Diabetes & Endocrinology (Thornhill) | Thornhill | Ontario |
| Canada | Canadian Phase Onward, Inc. | Toronto | Ontario |
| Canada | Dr. Anil K. Gupta Medicine Professional Corporation | Toronto | Ontario |
| Canada | JJ Dig Research LTD | Toronto | Ontario |
| Canada | LMC Diabetes & Endocrinology (Bayview) | Toronto | Ontario |
| Canada | Discovery Clinical Services Ltd. | Victoria | British Columbia |
| Canada | Victoria Heart Institute Foundation | Victoria | British Columbia |
| Canada | LMC Diabetes & Endocrinology (Montreal) | Ville Saint-Laurent | Quebec |
| Canada | Dr. Mohan Babapulle Medicine Professional Corporation | Waterloo | Ontario |
| Canada | Dr. Louis Yao | Weston | Ontario |
| Canada | Rivergrove Medical Clinic | Winnipeg | Manitoba |
| Canada | St. Boniface Hospital | Winnipeg | Manitoba |
| Canada | Unicity Laboratory Services | Winnipeg | Manitoba |
| Chile | Corporacion de Beneficencia Osorno | Osorno | Region DE LOS Lagos |
| Chile | Biomedica Research Group | Providencia Santiago | Metropolitana |
| Chile | Quantum Research | Puerto Varas | |
| Chile | Hospital Clinico Magallanes | Punta Arenas | Region DE Magallanes |
| Chile | CICAB | Santiago | Metropolitana |
| Chile | Complejo Asitencial Dr. Sotero del Rio | Santiago | Metropolitana |
| Chile | Hopsital y CRS El Pino | Santiago | Metropolitana |
| Chile | Servicios Medicos Godoy | Santiago | Region Metropolitana |
| Chile | SMOLAM | Santiago | Metropolitana |
| Chile | Centro de Investigacion Clínica del Sur | Temuco | Region DE LA Araucania |
| China | Inner Mongolia Baogang Hospital | Baotou | Inner Mongolia |
| China | Beijing Chao-yang Hospital | Beijing | |
| China | FuWai Hospital, CAMS & PUMC | Beijing | |
| China | China-Japan Union Hospital of Jilin University | Changchun | Jilin |
| China | Jilin Province People`s Hospital | Changchun | Jilin |
| China | The First Hospital of Jilin University | Changchun | Jilin |
| China | Changde First People's Hospital | Changde | Hunan |
| China | Changsha Central Hospital | Changsha | Hunan |
| China | Hunan Provincial People's Hospital | Changsha | Hunan |
| China | Guangdong General Hospital | Guangzhou | Guangdong |
| China | Haikou People's Hospital | Haikou | Hainan |
| China | The 2nd Affiliated Hospital Of Harbin Medical University | Harbin | Heilongjiang |
| China | The First Affiliated Hospital of Habrin Medical University | Harbin | Heilongjiang |
| China | The First Affiliated Hospital Of Harbin Medical University | Harbin | Heilongjiang |
| China | Inner Mongolia Autonomous Region People's Hospital | Hohhot | Inner Mongolia |
| China | Wuxi People's Hospital | Jiangsu | Jiangsu |
| China | Ningbo First hospital | Ningbo | Zhejiang |
| China | The Affiliated Hospital of Qingdao University | Qingdao | Shandong |
| China | Shanghai General Hospital | Shanghai | |
| China | Suzhou Kowloon Hospital Shanghai Jiaotong University School of Medicine | Suzhou | Jiangsu |
| China | Tianjin Union Medical Center | Tianjin | |
| China | The First Affiliated Hospital Of Xinjiang Medical University | Urumqi | Xinjiang |
| China | Pu Ai Hospital of Wuhan City | Wuhan | Hubei |
| China | The Central Hospital Of Wuhan | Wuhan | Hubei |
| China | Xiangtan City Central Hospital | Xiangtan | Hunan |
| China | The affiliated Hospital of Xuzhou Medical College | Xuzhou | Jiangsu |
| China | General Hospital Of Ningxia Medical University | Yinchuan | Ningxia |
| China | Taizhou Hospital of Zhejiang Province | Zhejiang | |
| China | The First Affiliated Hospital Of Zhengzhou University | Zhengzhou | Henan |
| China | Zhuzhou Central Hospital | Zhuzhou | Hunan |
| Colombia | Centro Cientifico Asistencial Jose Luis Accini S.A.S. | Barranquilla | Atlantico |
| Colombia | Clinica De La Costa Ltda | Barranquilla | Atlantico |
| Colombia | Corazon Ips Sas. | Barranquilla | Atlantico |
| Colombia | Fundacion del Caribe Para La Investigacion Biomedica - Fundacion BIOS | Barranquilla | Atlantico |
| Colombia | Hospital Universitario San Ignacio | Bogota D C | Cundinamarca |
| Colombia | Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA | Bogota D.C | Cundinamarca |
| Colombia | Dexadiab Servicios Medicos LTDA | Bogota D.C | Cundinamarca |
| Colombia | Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA. | Bogota D.C. | Cundinamarca |
| Colombia | MedPlus Medicina Prepagada S.A. | Bogota D.C. | Cundinamarca |
| Colombia | Simedics Ips Sas | Bogota D.C. | Cundinamarca |
| Colombia | Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO | Bogota D.C. | Cundinamarca |
| Colombia | Instituto del Corazon de Bucaramanga S.A. | Bucaramanga | Santander |
| Colombia | Fundacion Reina Isabel | Cali | Valle DEL Cauca |
| Colombia | Centro de Diagnostico Cardiologico LTDA. | Cartagena | Bolivar |
| Colombia | Fundacion Cardiovascular De Colombia - Instituto del Corazón Floridablanca | Floridablanca | Santander |
| Colombia | Fundacion Cardiovascular De Colombia - Instituto del Corazón Floridablanca | Floridablanca | Santander |
| Colombia | Asociacion IPS Medicos Internistas de Caldas | Manizales | Caldas |
| Colombia | Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM | Medellin | Antioquia |
| Colombia | Centro de Medicina del Ejercicio y Rehabilitacion Cardiac - CEMDE S.A. | Medellin | Antioquia |
| Colombia | Hospital Pablo Tobon Uribe | Medellin | Antioquia |
| Colombia | Rodrigo Botero S.A.S. | Medellin | Antioquia |
| Colombia | Fundacion Centro de Obesidad y Metabolismo COMETA | Pasto | Narino |
| Colombia | Healthy Medical Center S.A.S | Zipaquira | Cundinamarca |
| Czechia | CCBR Czech Brno, s.r.o. | Brno | |
| Czechia | Kardiologicka Ambulance | Brno | Jihomoravsky KRAJ |
| Czechia | Edumed S.R.O. | Broumov | Kralovehradecky KRAJ |
| Czechia | DIKa centrum s.r.o., Kardiologicka a interni ambulance | Havirov | |
| Czechia | Fakultni Nemocnice Hradec Kralove | Hradec Kralove | |
| Czechia | Fakultni nemocnice Hradec Kralove | Hradec Kralove | |
| Czechia | EDUMED s.r.o. | Jaromer | Kralovehradecky KRAJ |
| Czechia | Fremlova Apotheca s.r.o. | Litovel | |
| Czechia | Kardio interna s.r.o. | Litovel | |
| Czechia | Fakultni Nemocnice Olomouc | Olomouc | |
| Czechia | Mudr. Jan Vrkoc S.R.O. | Ostrava | Moravskoslezsky KRAJ |
| Czechia | CCBR Czech a.s. | Pardubice | |
| Czechia | Pv-Kardiologie S.R.O. | Pardubice | Pardubicky KRAJ |
| Czechia | Kardiologie Plzen s.r.o. | Plzen | |
| Czechia | Centrum kardiovaskularni prevence 1. LF UK a TN | Praha | |
| Czechia | Fakultni Nemocnice Kralovske Vinohrady | Praha 10 | |
| Czechia | Fakultni poliklinika Vseobecne fakultni nemocnice v Praze | Praha 2 | |
| Czechia | CCBR Czech Prague, s.r.o | Praha 3 | |
| Czechia | Kardiologie a interni lekarstvi | Praha 5 | |
| Czechia | NEFROMED, s.r.o. | Praha 6 | |
| Czechia | Interna a kardiologie s.r.o. | Roznov pod Radhostem | |
| Czechia | Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice | Svitavy | |
| Czechia | Ordinace V Tabacce s.r.o. | Tabor | |
| Czechia | Kardiologicka ambulance | Trutnov | Kralovehradecky KRAJ |
| Czechia | Lekarna na Poliklinice | Trutnov | Kralovehradecky KRAJ |
| Czechia | MUDr. Antonin Dufka, kardiologicka ambulance | Uherske Hradiste 1 | |
| Czechia | MUDr. Nina Zemkova s.r.o. | Uherske Hradiste 1 | |
| Czechia | KIGE s.r.o. | Znojmo | |
| Denmark | Aabenraa Hospital Hjertemedicinsk klinik Kredslobscentret, SHS | Aabenraa | |
| Denmark | Sygehus Sonderjylland Aabenraa | Aabenraa | |
| Denmark | Aalborg Universitetshospital, Lipidklinikken | Aalborg | |
| Denmark | CCBR Aalborg | Aalborg | |
| Denmark | Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning | Aarhus | |
| Denmark | CCBR Ballerup | Ballerup | |
| Denmark | Bispebjerg og Frederiksberg Hospital | Copenhagen NV | |
| Denmark | Sydvestjysk Sygehus, Hjertemedicinsk Projektgruppe | Esbjerg | |
| Denmark | Frederiksberg Hospital | Frederiksberg | |
| Denmark | Glostrup Hospital | Glostrup | |
| Denmark | Herlev Universitetshospital | Herlev | |
| Denmark | Regionshospitalet Herning | Herning | |
| Denmark | Hillerod Hospital | Hillerod | |
| Denmark | Hvidovre Universitetshospital | Hvidovre | |
| Denmark | Karkirurgisk Klinisk | Kobenhavn O | |
| Denmark | Amager Hospital | Kobenhavn S. | |
| Denmark | Region Sjaelland Sygehus Nord, Koge Sygehus | Koege | |
| Denmark | Kolding Sygehus | Kolding | |
| Denmark | Region Sjaelland Naestved Sygehus | Naestved | |
| Denmark | Nykobing F. Sygehus-Medicinsk afdeling | Nykobing F. | |
| Denmark | Regionshospitalet Randers | Randers | |
| Denmark | Regionshospitalet Silkeborg, Hjerte Projektkontor | Silkeborg | |
| Denmark | Slagelse Sygehus | Slagelse | |
| Denmark | Svendborg Sygehus | Svendborg | |
| Denmark | CCBR Vejle | Vejle | |
| Denmark | Hospitalsenheden Midt, Regionshospital Viborg | Viborg | |
| Finland | HYKS Jorvin sairaala | Espoo | |
| Finland | Linnan Klinikka Oy | Hameenlinna | |
| Finland | Geri-Med Oy | Helsinki | |
| Finland | Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U | Helsinki | |
| Finland | Helsinki University Central Hospital | Helsinki | |
| Finland | Ita-Suomen laakarikeskus Oy | Joensuu | |
| Finland | StudyCor Oy | Jyvaskyla | |
| Finland | Laeaekaerikeskus Aava Kerava | Kerava | |
| Finland | Menoa oy | Kinkomaa | |
| Finland | Kokkolan Keskussairaala | Kokkola | |
| Finland | Mewell liikuntaklinikka | Kotka | |
| Finland | Itae-Suomen Laeaekaeritalo | Kuopio | |
| Finland | Terveystalo Kuopio | Kuopio | |
| Finland | Oulu Mentalcare Oy | Oulu | |
| Finland | Oulu University Hospital | Oulu | |
| Finland | Terveystalo Oulu, Diapolis | Oulu | |
| Finland | Porin Laakaritalo Oy | Pori | |
| Finland | Terveystalo Siilinjarvi | Siilinjarvi | |
| Finland | FinnMedi Oy | Tampere | |
| Finland | Terveystalo Pulssi | Turku | |
| Finland | Turku University hospital | Turku | |
| Finland | Vantaan Tutkimuskeskus | Vantaa | |
| Finland | Ylitornion Terveyskeskus | Ylitornio | |
| France | CHU Jean Minjoz Cardiologie | Besancon | |
| France | Groupe Hospitalier de Pellegrin Hopital Pellegrin | Bordeaux | |
| France | Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat | Bourg En Bresse Cedex 10000 | |
| France | centre hospitalier Sub-Francilien | Corbeil-Essonnes | |
| France | Scp Cardiovasculaire De L'Est | Essey-Les-Nancy | |
| France | Centre Hospitalier Louis Pasteur | Le Coudray | |
| France | Hopital La Louviere | Lille | |
| France | Centre Hospitalier Saint Philibert | Lomme | |
| France | Hopital Cardiovasculaire Et Pneumologique Louis Pradel | Lyon Cedex 03 | |
| France | Hopital Arnaud de Villeneuve - CHU Montpellier | Montpellier cedex 5 | |
| France | CHU de Nantes - Hopital Nord Laennec | Nantes | |
| France | Nouvelles Cliniques Nantaises | Nantes | |
| France | Chu De Nice - Hopital Pasteur | Nice Cedex 1 | |
| France | Hopital Cardiologique | Pessac cedex | |
| France | CHU de Poitiers | Poitiers Cedex | |
| France | CHU de Renes Hopital de Pontchaillou | Rennes Cedex 9 | |
| France | CHU de Toulouse | Toulouse cedex 9 | |
| France | Hospital Cuy Chatilliez | Tourcoing | |
| France | Hopital Trousseau | Tours Cedex 9 | |
| France | Centre Hospitalier (GH) de Valenciennes | Valenciennes | |
| France | Polyclinique Vauban | Valenciennes | |
| Germany | Klinikum Altenburger Land Gmbh | Altenburg | |
| Germany | Forschungszentrum Dr. med Irma Schoell | Bad Homburg | |
| Germany | Universitaets Herzzentrum Freiburg Bad Krozingen | Bad Krozingen | Baden-wuerttemberg |
| Germany | Deutsches Herzzentrum Berlin | Berlin | |
| Germany | DRK Kliniken Berlin Kopenick, Zentrum Klinische Forschung | Berlin | |
| Germany | Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH | Berlin | |
| Germany | Klinische Forschung Berlin- Mittte GmbH | Berlin | |
| Germany | Medizinisches Versorgungszentrum am Bahnhof Spandau | Berlin | |
| Germany | POLIKUM Institut GmbH, Polikum Berlin Friedenau | Berlin | |
| Germany | Synexus Clinical Research GmbH | Berlin | |
| Germany | Staedtische Kliniken Bielefeld Gem. GmbH - Klinikum Mitte | Bielefeld | |
| Germany | Bochum Research Centre-Synexus Clinical Research GmbH | Bochum | |
| Germany | Synexus Clinical Research GmbH | Bochum | |
| Germany | MediClin Reha-Zentrum Spreewald | Burg-Spreewald | |
| Germany | Klinikum Coburg | Coburg | |
| Germany | Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel | Dortmund | |
| Germany | Kardiologische Praxisgemeinschaft | Dortmund | |
| Germany | St. Johannes-Hospital | Dortmund | |
| Germany | GWT-TUD GmbH, Studienzentrum Professor Hanefeld | Dresden | |
| Germany | Klinsche Forschung Dresden GmbH | Dresden | |
| Germany | Praxis Dr. med. Christoph Axthelm | Dresden | |
| Germany | Gemeinschaftspraxis Dr. Hagemann/Breiderhoff/Durfeld | Essen | |
| Germany | Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg | Essen | |
| Germany | Medizentrum Essen Borbeck | Essen | |
| Germany | Studienzentrum | Essen | |
| Germany | Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin | Falkensee | |
| Germany | Clinphenomics Gmbh & Co Kg, Studienzentrum | Frankfurt | |
| Germany | Synexus Clinical Research GmbH | Frankfurt | |
| Germany | IKF Institut fuer klinische Forschung Frankfurt | Frankfurt am Main | |
| Germany | Gemeinschaftspraxis im Altstadt Carree | Fulda | Hessen |
| Germany | Klinik und Poliklinik fuer Innere Medizin B - Kardiologie, Angiologie, Pulmologie | Greifswald | |
| Germany | Cardiologicum Hamburg | Hamburg | |
| Germany | Praxis Dr. med Cornelia Brauer | Hamburg | |
| Germany | Klinische Forschung Hannover-Mitte GmbH | Hannover | |
| Germany | Medizinische Universitaetsklinik Heidelberg | Heidelberg | Baden-wurttemberg |
| Germany | Universitaetsklinikum des Saarlandes Klinik fuer Innere Medizin III | Homburg | |
| Germany | Praxis Dr. Heister | Kamp-Lintfort | |
| Germany | Studienzentrum Dr. Appel | Kassel | |
| Germany | Zentrum fuer klinische Forschung | Koeln | |
| Germany | Gemeinschaftspraxis Dr. Klein / Minnich | Kuenzing | |
| Germany | Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden. | Lahr | |
| Germany | Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut | Leipzig | |
| Germany | SIBAmed Studienzentrum GmbH & Co. KGKG | Leipzig | |
| Germany | Synexus Leipzig Clinical Research Centre | Leipzig | |
| Germany | Klinikum Leverkusen GgmbH | Leverkusen | |
| Germany | Klinikum der Stadt Ludwigshafen am Rhein gGmbH | Ludwigshafen | |
| Germany | Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III | Luedenscheid | |
| Germany | Klinikum Lunen, St. Marienhospital | Lunen | |
| Germany | SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit | Magdeburg | |
| Germany | Pfuetzner Science & Health Institute-Gmbh | Mainz | |
| Germany | Ze:ro Arztpraxen Dr. med. Salbach | Mannheim | |
| Germany | Klinikum fuer Herz- & Kreislauferkrankungen | Muenchen | |
| Germany | Klinikum Der Universitat Munchen | Munchen | |
| Germany | Klinikum Fur Herz- & Kreislauferkrankungen | Munich | |
| Germany | Staedtisches Klinikum Muenchen GmbH, Klinikum Neuperlach | Munich | |
| Germany | Zentrum Klinische Studien Neuwied (ZKSN) | Neuwied | Rheinland Pfalz |
| Germany | Kardiologische Praxis Northeim | Northeim | |
| Germany | Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin | Nurnberg | |
| Germany | Allgemeinmedizinisch-Internistische Praxisgemeinschaft | Offenbach | |
| Germany | Praxis Dres. Med Naudts und Nowack | Rodgau | |
| Germany | Klinik Am See - Klinik Am See - Rehabilitationszentrum Fur Innere Medizin | Rudersdorf | |
| Germany | Gemeinschaftspraxis Schwabenheim | Schwabenheim | Rhineland-palatinate |
| Germany | Klinische Forschung Schwerin GmbH | Schwerin | |
| Germany | Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Buerger | Soest | |
| Germany | Praxisgemeinschaft Stuhr-Brinkum | Stuhr-Brinkum | |
| Germany | Robert-Bosch-Krankenhaus | Stuttgart | |
| Germany | Universitaetsklinikum Ulm | Ulm | |
| Germany | Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie | Warendorf | |
| Germany | Kardiologische Praxis | Wermsdorf | |
| Germany | ForschungszentrumRuhr KliFoCenter GmbH | Witten | |
| Hungary | DRC Kft. | Balatonfured | |
| Hungary | DRC Kft. | Balatongyorok | |
| Hungary | Kardiologiai Maganrendelo | Bekescsaba | |
| Hungary | Grof Tisza Istvan Korhaz Berettyoujfalu | Berettyoujfalu | |
| Hungary | Bajcsy-Zsilinszky Korhaz es Rendelointezet | Budapest | |
| Hungary | Budapesti Szent Ferenc Korhaz | Budapest | |
| Hungary | Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet | Budapest | |
| Hungary | Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Budapest | |
| Hungary | Semmelweis Egyetem | Budapest | |
| Hungary | Synexus Magyarorszag Kft | Budapest | |
| Hungary | Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly | Budapest | |
| Hungary | Szent Rokus Korhaz | Budapest | |
| Hungary | Debreceni Egyetem, I. sz. Belgyogyaszati Klinika | Debrecen | |
| Hungary | Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft. | Debrecen | |
| Hungary | Synexus Magyarorszag Kft. | Gyula | |
| Hungary | Edes Szivunk Egeszsegkozpont Kft. | Hajduszoboszlo | |
| Hungary | BKS Research Kft., Albert Schweitzer Korhaz | Hatvan | |
| Hungary | Somogy Megyei Kaposi Mór Oktató Kórház | Kaposvar | |
| Hungary | Bacs-Kiskun Megyei Korhaz | Kecskemet | Bacs-kiskun |
| Hungary | Jutrix Egeszsegugyi Kft | Kecskemet | |
| Hungary | Pest Megyei Flor ferenc Korhaz | Kistarcsa | |
| Hungary | Josa Andras Oktatokorhaz | Nyiregyhaza | |
| Hungary | Medifarma-98 Kft. | Nyiregyhaza | |
| Hungary | Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika | Pecs | |
| Hungary | Pecsi Tudomanyegyetem AOK, II. | Pecs | Baranya |
| Hungary | Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika | Szeged | Csongrad |
| Hungary | Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Szekesfehervar | Fejer |
| Hungary | Mentahaz Maganorvosi Kozpont | Szekesfehervar | |
| Hungary | Hetenyi Geza Korhaz | Szolnok | |
| Hungary | Markusovszky Egyetemi Oktatokarhaz | Szombathely | |
| Hungary | Dr. Sydo es Tsa Kft | Veszprem | |
| Hungary | Zala Megyei Korhaz | Zalaegerszeg | |
| India | Apex Heart Institute (A Unit of TCVS Pvt. Ltd) | Ahmedabad | Gujarat |
| India | Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre | Ahmedabad | Gujarat |
| India | SAL Hospital | Ahmedabad | Gujarat |
| India | Mediciti Hospitals | Hyderabad | Telangana |
| India | Aster Aadhar Hospital (Prerana Hospital Ltd.) | Kolhapur | Maharashtra |
| India | M.V. Hospital And Research Centre | Lucknow | Uttar Pradesh |
| India | Shri Krishna Hrudayalaya and Critical Care Centre | Nagpur | Maharashtra |
| India | Jehangir Clinical Development Centre Pvt. Ltd. | Pune | Maharashtra |
| India | Apple Hospital | Surat | Gujarat |
| India | BAPS - Pramukh Swami Hospital | Surat | Gujarat |
| India | Unicare Heart Institute & Research Center | Surat | Gujarat |
| India | Rhythm Heart Institute | Vadodara | Gujarat |
| Ireland | Beaumont Hospital | Dublin | Leinster |
| Ireland | Mater Misericordiae University Hospital | Dublin | |
| Ireland | St. James's Hospital | Dublin | |
| Ireland | The Adelaide & Meath Hospital-Dublin Incorporating The National Children's Hospital | Dublin | |
| Ireland | Health Research Board | Galway | |
| Ireland | Portiuncula Hospital | Galway | |
| Israel | Barzilai Medical Center | Ashkelon | |
| Israel | Gefen Institute for Research and Cardiac Health | Bat Yam | |
| Israel | The Soroka University Medical Center | Beer Sheva | |
| Israel | Ben Yair Community Clinic - Clalit Health Services | Beer-Sheva | |
| Israel | Heart Institute, Hillel Yaffe Medical Center | Hadera | |
| Israel | Cardiovascular Clinical Research Institute | Haifa | |
| Israel | Rambam Medical Center | Haifa | |
| Israel | Edith Wolfson Medical Center | Holon | |
| Israel | Hadassah Ein Kerem Medical Center | Jerusalem | |
| Israel | Heart Institute, Bikur Cholim Campus, Shaare Zedek Medical Center | Jerusalem | |
| Israel | Meir Medical Center | Kfar Saba | |
| Israel | Meir Medical Center | Kfar-Saba | |
| Israel | Galilee Medical Center, Cardiology Department | Nahariya | |
| Israel | E.M.M.S Nazareth Hospital | Nazareth | |
| Israel | Sha'aria Clinic, Clalit Health Services | Petach Tikva | |
| Israel | Rabin Medical Center | Petah Tikva | |
| Israel | Rabin Medical Center, Beilinson Hospital | Petah Tikva | |
| Israel | Rabin Medical Center-Beilinson Hospital | Petah Tikva | |
| Israel | Shuali Community Clinic, Clalit Health Services | Raanana | |
| Israel | Department of Neurology & Sagol Neuroscience Center | Ramat Gan | |
| Israel | Heart Institute, Kaplan Medical Center | Rehovot | |
| Israel | Kaplan Medical Center | Rehovot | |
| Israel | Internal Medicine A, Ziv Medical Center | Safed | |
| Israel | Assuta Medical Center | Tel Aviv | |
| Israel | The Chaim Sheba Medical Center | Tel HaShomer | |
| Israel | Tel Aviv Sourasky Medical Center | Tel-Aviv | |
| Italy | I.N.R.C.A. di Ancona Ospedale Geriatrico | Ancona | |
| Italy | Ospedale Civile Regionale San Martino, Belluno | Belluno | |
| Italy | Azienda Ospedaliera G. Brotzu | Cagliari | |
| Italy | AOU Policlinico "Mater Domini" UOC di Medicina interna | Catanzaro | CZ |
| Italy | Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni | Lecco | Province OF Lecco |
| Italy | Ospedale S. L. Mandic di Merate | Merate | Lecco |
| Italy | IRCCS Centro Cardiologico Fondazione Monzino | Milano | MI |
| Italy | Divisione di Cardiologia con UTIC ed Emodinamica | Naples | |
| Italy | Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli | Napoli | |
| Italy | Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli | Napoli | |
| Italy | AOU Policlinico "P. Giaccone" Dipartimento delle Patologie Emergenti, Unita di Medicina Interna | Palermo | PA |
| Italy | Ospedale S. Maria della Misericordia Dipartimento di Medicina, Medicina Interna, | Perugia | PG |
| Italy | Ospedale Civile Di Piove Di Sacco | Piove Di Sacco | Padova |
| Italy | A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS | Reggio Emilia | |
| Italy | AUSL Della Romagna-Ospedale Infermi | Rimini | |
| Italy | Dept."Medicina lnterna e Specialita Mediche" dell' Universita degli | Roma | RM |
| Italy | Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia | Rome | RM |
| Italy | Policlinico Umberto I di Roma | Rome | RM |
| Italy | Policlinico Umberto I di Roma - DAI Malattie Cardiovascolari e Respiratorie | Rome | |
| Italy | Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo | Rovigo | |
| Italy | A.O.U. San Giovanni di Dio e Ruggi d'Aragona U.O.C. UTIC | Salerno | |
| Italy | Ospedale G. Fracastoro | San Bonifacio | Verona |
| Italy | Presidioospedaliero di san dona 'di PIAVE | San Dona Di Paive | Venezia |
| Italy | A.O. Treviglio e Caravaggio | Treviglio (BG) | Bergamo |
| Italy | Azienda Ospedaliera Universitaria Santa Maria Della Misericordia | Udine | |
| Italy | AOUI di Verona - Ospedale Civile Maggiore Borgo Trento | Verona | VR |
| Korea, Republic of | Dong-A University Hospital | Busan | |
| Korea, Republic of | Inje University Busan Paik Hospital | Busan | |
| Korea, Republic of | Chungbuk National University Hospital | Cheongju-si | Chungcheonbuk-do |
| Korea, Republic of | Kangwon National University Hospital | Chuncheon-si | Gangwon-do |
| Korea, Republic of | Daegu Catholic University Medical Center | Daegu | |
| Korea, Republic of | Daejeon St. Mary's Hospital-The Catholic University of Korea | Daejeon | |
| Korea, Republic of | Konyang University Hospital | Daejeon | |
| Korea, Republic of | Dongguk University Ilsan Hospital | Goyang-si | Gyeonggi-do |
| Korea, Republic of | Inje University Ilsan Paik Hospital | Goyang-Si | Gyeonggi-do |
| Korea, Republic of | MyongJi Hospital | Goyang-si | Gyeonggi-do |
| Korea, Republic of | Chonnam National University Hospital | Gwangju | |
| Korea, Republic of | Gachon University Gil Medical Center | Incheon | |
| Korea, Republic of | Inha University Hospital | Jung-gu | Incheon |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do |
| Korea, Republic of | Asan Medical Center | Seoul | |
| Korea, Republic of | Gangnam Severance Hospital, Yonsei University Health System | Seoul | |
| Korea, Republic of | Hallym University Kangdong Sacred Heart Hospital | Seoul | |
| Korea, Republic of | SMG-SNU Boramae Medical Center | Seoul | |
| Korea, Republic of | Ajou University Hospital | Suwon-si | Gyeonggi-do |
| Korea, Republic of | Uijeongbu St. Mary's Hospital-The Catholic University of Korea | Uijeongbu-si | Gyeonggi-do |
| Korea, Republic of | Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital | Wonju-Si | Gangwon-do |
| Mexico | Centro de Investigacion Clinica del Pacifico, S.A. de C.V. | Acapulco de Juarez | Guerrero |
| Mexico | Centro de Investigacion Cardiometabolica de Aguascalientes S.A. de C.V. | Aguascalientes | |
| Mexico | Centro Hospitalario Mac, S.A. de C.V. (Emergencies) | Aguascalientes | |
| Mexico | Hospital Cardiologica Aguescalientes | Aguascalientes | |
| Mexico | Instituto Biomedico De Investigacion A.C. | Aguascalientes | |
| Mexico | Consultorio Dr. Leocadio Gerardo Munoz Beltran | Cd. Juarez | Chihuahua |
| Mexico | Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia | Chihuahua | |
| Mexico | Investigacion en Salud y Metabolismo S.C | Chihuahua | |
| Mexico | Investigacion en Salud y Metabolismo S.C. | Chihuahua | |
| Mexico | Unidad de Investigacion en Salud de Chihuahua S.C. | Chihuahua | |
| Mexico | Hospital Inovamed Cuernavaca (Emergencies) | Cuernavaca | Morelos |
| Mexico | Instituto de Diabetes Obesidad y Nutricion, S.C. | Cuernavaca | Morelos |
| Mexico | Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. | Culiacan | Sinaloa |
| Mexico | Hospital Angeles Culiacan (Emergencies Only) | Culiacan | Sinaloa |
| Mexico | Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran | Distrito Federal | |
| Mexico | Cardioprevent, S.C. | Durango | |
| Mexico | Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C. | Durango | |
| Mexico | Centro de Investigacion Medica Integral S.C. | Guadalajara | Jalisco |
| Mexico | CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco SC | Guadalajara | Jalisco |
| Mexico | Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez | Guadalajara | Jalisco |
| Mexico | Hospital Mexico Americano S.C. (Emergencies) | Guadalajara | Jalisco |
| Mexico | Instituto de Terapeutica Experimental y Clinica (INTEC) Centro Universitario de Ciencias de la Salud | Guadalajara | Jalisco |
| Mexico | Unidad de Investigacion Clinica y Atencion Medica HEPA S.C. | Guadalajara | Jalisco |
| Mexico | Centro de Atencion e Investigacion en Factores de Riesgo Cardiovascular Omega S.C | Mexico | DF |
| Mexico | Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares, S.C. | Mexico | D F |
| Mexico | Consultorio de Endocrinologia y Nutriologia | Mexico | Distrito Federal |
| Mexico | Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran" | Mexico | Distrito Federal |
| Mexico | Operadora de Hospitales Angeles S.A. de C.V.(Emergencies) | Mexico | Distrito Federal |
| Mexico | Accelerium S. de R.L. de C.V. | Monterrey | Nuevo LEON |
| Mexico | Cardiolink Clin Trials, S.C. | Monterrey | Nuevo LEON |
| Mexico | CRI Centro Regiomontano de Investigacion SC | Monterrey | Nuevo LEON |
| Mexico | Global Trial Research Center S.A. de C.V. | Monterrey | Nuevo LEON |
| Mexico | Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey | Nuevo LEON |
| Mexico | Hospital Universitario De Monterrey- "Doctor Jose Eleuterio Gonzalez" | Monterrey | Nuevo LEON |
| Mexico | Hospital y Clinica OCA, S.A. de C.V. | Monterrey | Nuevo LEON |
| Mexico | Monterrey International Research Center | Monterrey | Nuevo LEON |
| Mexico | Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V. | Pachuca | Hidalgo |
| Mexico | Pharmacology and Clinical Research S.A. de C.V. | Queretaro | |
| Mexico | Centro Integral Medico SJR S.C | San Juan del Rio | Queretaro |
| Mexico | "Hospital Central ""Dr. Ignacio Morones Prieto""" | San Luis Potosi | |
| Mexico | Cardioarritmias e Investigacion S.C. | San Luis Potosi | |
| Mexico | Hospital Lomas de San Luis Intemacional (Emergencies) | San Luis Potosi | |
| Mexico | Fundacion Santos y de la Garza Evia I.B.P. (Centro Medico Zambrano Hellion) | San Pedro Garza Garcia | Nuevo LEON |
| Mexico | Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C. | Tampico | Tamaulipas |
| Mexico | Centro Especializado En Diabetes Y Metabolismo | Veracruz | |
| Mexico | Centro de Especialidades Medicas del Estado de Veracruz | Xalapa | Veracruz |
| Mexico | Jardines Hospital de Especialidades S.A de C.V | Zapopan | Jalisco |
| Netherlands | Noordwest Ziekenhuisgroep | Alkmaar | |
| Netherlands | EB Flevoresearch | Almere | |
| Netherlands | Meander Medical Center | Amersfoort | |
| Netherlands | Meander Medisch Centrum | Amersfoort | |
| Netherlands | Amstelland Hospital | Amstelveen | |
| Netherlands | Academic Medical Center | Amsterdam | |
| Netherlands | Bovenij Ziekenhuis | Amsterdam | |
| Netherlands | OLVG, locatie West | Amsterdam | |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | |
| Netherlands | VU University Medical Center | Amsterdam | |
| Netherlands | Gelre Hospitals | Apeldoorn | |
| Netherlands | Rode Kruis Ziekenhuis | Beverwijk | |
| Netherlands | Tergooi Ziekenhuis | Blaricum | |
| Netherlands | Amphia Ziekenhuis | Breda | |
| Netherlands | Andro Medical Research B.V. | Breda | |
| Netherlands | Reinier de Graaf ziekenhuis | Delft | |
| Netherlands | Hagaziekenhuis | Den Haag | |
| Netherlands | Hedramed | Den Haag | |
| Netherlands | Hedramed | Den Haag | |
| Netherlands | HMC (Haaglanden Medisch Centrum) Bronovo | Den Haag | |
| Netherlands | Deventer Ziekenhuis | Deventer | |
| Netherlands | Van Weel Bethesda Hospital | Dirksland | |
| Netherlands | Slingeland Ziekenhuis | Doetinchem | |
| Netherlands | Albert Schweitzer Hospital | Dordrecht | |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | |
| Netherlands | Andromed Eindhoven | Eindhoven | |
| Netherlands | Heartcentre Catharina Hospital | Eindhoven | |
| Netherlands | Medisch Spectrum Twente | Enschede | |
| Netherlands | Beatrix Ziekenhuis | Gorinchem | |
| Netherlands | Groene Hart Ziekenhuis | Gouda | |
| Netherlands | Martini Ziekenhuis | Groningen | |
| Netherlands | University Medical Center Groningen | Groningen | |
| Netherlands | Spaarne Gasthuis | Haarlem | |
| Netherlands | St. Jansdal Ziekenhuis | Harderwijk | |
| Netherlands | Tjongerschans Ziekenhuis | Heerenveen | Friesland |
| Netherlands | Zuyderland | Heerlen | |
| Netherlands | Zuyderland Medisch Centrum | Heerlen | |
| Netherlands | Treant Zorggroep, location Bethesda | Hoogeveen | |
| Netherlands | Vascular Research Centre | Hoorn | |
| Netherlands | Quality Care Research | Kloosterhaar | |
| Netherlands | Medisch Centrum Leeuwarden | Leeuwarden | |
| Netherlands | Alrijne Ziekenhuis | Leiden | |
| Netherlands | Leiden University Medical Center | Leiden | |
| Netherlands | Alrijne Ziekenhuis | Leiderdorp | |
| Netherlands | GCM Maarssenbroek | Maarssen | |
| Netherlands | Maastricht University Medical Center | Maastricht | |
| Netherlands | Isala Diaconessenhuis | Meppel | |
| Netherlands | St Antonius Hospital | Nieuwegein | |
| Netherlands | Canisius Wilhelmina Ziekenhuis | Nijmegen | |
| Netherlands | Radboud University Nijmegen Medical Centre | Nijmegen | |
| Netherlands | Waterland Hospital | Purmerend | |
| Netherlands | Andro Medical Research B.V | Rotterdam | |
| Netherlands | Ikazia Ziekenhuis | Rotterdam | |
| Netherlands | Rotterdam Research Institute | Rotterdam | |
| Netherlands | St. Franciscus Gasthuis | Rotterdam | Zuid-holland |
| Netherlands | St. Fransiscus Gasthuis | Rotterdam | |
| Netherlands | Zuyderland MC | Sittard-Geleen | Limburg |
| Netherlands | D&A Research and Genetics | Sneek | |
| Netherlands | Ziekenhuis Rivierenland | Tiel | |
| Netherlands | Elisabeth TweeSteden Ziekenhuis (ETZ) | Tilburg | |
| Netherlands | Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis) | Tilburg | |
| Netherlands | St. Elisabeth Ziekenhuis | Tilburg | |
| Netherlands | Bernhoven Ziekenhuis | Uden | |
| Netherlands | EB Utrecht | Utrecht | |
| Netherlands | Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU | Utrecht | |
| Netherlands | University Medical Center Utrecht | Utrecht | |
| Netherlands | Maxima Medisch Centrum | Veldhoven | |
| Netherlands | VieCuri Medisch Centrum | Venlo | |
| Netherlands | Twee Steden Ziekenhuis | Waalwijk | |
| Netherlands | Het Lange Land Ziekenhuis | Zoetermeer | Zuid-holland |
| Netherlands | Albert Schweitzer Hospital | Zwijndrecht | |
| Netherlands | Isala | Zwolle | Overijssel |
| New Zealand | Auckland City Hospital | Auckland | |
| New Zealand | Lipid and Diabetes Research Group | Christchurch | |
| New Zealand | Southern Clinical Trials Riccarton | Christchurch | |
| New Zealand | Southern Clinical Trials Shirley Ltd | Christchurch | |
| New Zealand | RMC Medical Research Ltd. | Dunedin | |
| New Zealand | Hawke's Bay Hospital | Frimley | Hastings |
| New Zealand | Optimal Clinical Trials | Grafton | Auckland |
| New Zealand | Henderson Medical Centre | Henderson | Auckland |
| New Zealand | Taranaki Base Hospital | New Plymouth | |
| New Zealand | Middlemore Hospital | Otahuhu | Auckland |
| New Zealand | Rotorua Hospital | Rotorua | |
| New Zealand | North Shore Hospital | Takapuna | Auckland |
| New Zealand | Clinical Horizons NZ Ltd | Tauranga | |
| New Zealand | Clinical Horizons NZ Ltd. | Tauranga | |
| New Zealand | Clinical Trials Unit,Bay of Plenty(BOP) Clinicla School | Tauranga | |
| New Zealand | Papamoa Pines Medical Centre | Tauranga | |
| New Zealand | Wellington Hospital | Wellington | |
| Poland | "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik | Bialystok | Podlaskie |
| Poland | Podlaski Osrodek Kardiologii Janusz Korecki | Bialystok | Podlaskie |
| Poland | Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial | Brzozow | Podkarpackie |
| Poland | Nzoz Centrum Medyczne Kermed | Bydgoszcz | Kujawsko-pomorskie |
| Poland | NZOZ Vitamed | Bydgoszcz | Kujawsko-pomorskie |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu | Bytom | Slaskie |
| Poland | Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej | Elblag | Warminsko-mazurskie |
| Poland | Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna | Gdansk | Pomorskie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna | Gdansk | Pomorskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Gdansku | Gdansk | Pomorskie |
| Poland | Gabinet Kardiologiczno - lnternistyczny | Gdynia | Pomorskie |
| Poland | Marek Piepiorka Gabinet Kardiologiczno - lnternistyczny | Gdynia | |
| Poland | Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni | Gdynia | Pomorskie |
| Poland | NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych | Gdynia | Pomorskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Gdyni | Gdynia | Pomorskie |
| Poland | Specjalistyczna Praktyka Lekarska Piotr Kubalski | Grudziadz | Kujawsko-pomorskie |
| Poland | Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna | Jelenia Gora | Dolnoslaskie |
| Poland | Bogna Gabrylewicz Andrzej Ochala Unimed s.c. | Katowice | Slaskie |
| Poland | NZOZ Terapia Optima | Katowice | Slaskie |
| Poland | Pro Familia Altera Poradnia Wielospecjalistyczna | Katowice | Slaskie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Katowicach | Katowice | Mazowieckie |
| Poland | Prywatny Gabinet Lekarski Marianna Janion | Kielce | Swietokrzyskie |
| Poland | CENTRUM MEDYCZNE A-Z Clinic | Krakow | Malopolskie |
| Poland | Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka jawna | Krakow | Malopolskie |
| Poland | Krakowski Szpital Specjalistyczny im. Jana Pawla II | Krakow | Malopolskie |
| Poland | Krakowskie Centrum Medyczne Sp. z o.o. | Krakow | Malopolskie |
| Poland | Landa Specjalistyczne Gabinety Lekarskie | Krakow | Malopolskie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o., sp.k. | Krakow | Malopolskie |
| Poland | NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o. | Krakow | Malopolskie |
| Poland | NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o. | Krakow | |
| Poland | Nzoz Gall-Med | Krakow | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, | Krakow | Malopolskie |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie, Ambulatoria | Krakow | Malopolskie |
| Poland | Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii | Krakow | Malopolskie |
| Poland | INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie | Krosno | Podkarpackie |
| Poland | "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider | Lodz | Lodzkie |
| Poland | Gabinet Lekarski Malgorzata Saryusz-Wolska | Lodz | Lodzkie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej CEREO-MED Sp. z o.o. | Lodz | Lodzkie |
| Poland | Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. Jednostka 02 | Lodz | Lodzkie |
| Poland | SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi 251 Pomorska | Lodz | Wojewodztwo Lodzkie |
| Poland | "TWOJA PRZYCHODNIA" Sp. Z o.o | Lublin | |
| Poland | Clinical Best Solutions | Lublin | Lubelskie |
| Poland | KO-MED Centra Kliniczne Lublin II | Lublin | Lubelskie |
| Poland | Optimamed Specjalistyczne Gabinety Lekarskie | Lublin | Lubelskie |
| Poland | NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska | Myslenice | Malopolskie |
| Poland | INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu | Nowy Targ | Malopolskie |
| Poland | Medicus w Opolu Sp z o. o. | Opole | |
| Poland | Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota | Ostroda | Warminsko-mazurskie |
| Poland | Medicome Sp. z o.o. | Oswiecim | Malopolskie |
| Poland | Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek | Piotrkow Trybunalski | Lodzkie |
| Poland | Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD" | Plock | Mazowieckie |
| Poland | Centrum Zdrowia Metabolicznego Pawel Bogdanski | Poznan | |
| Poland | Nzoz "Twoja Przychodnia" | Poznan | Wielkopolskie |
| Poland | Synexus Polska Sp. z o.o Oddzial w Poznaniu | Poznan | Wielkopolskie |
| Poland | KO-MED Centra Kliniczne Pulawy | Pulawy | Lubelskie |
| Poland | NZOZ PRZYCHODNIA SPECJALISTYCZNA Andrzej Wittek Henryk Rudzki s.c. | Ruda Slaska | |
| Poland | Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, | Ruda Slaska | Slaskie |
| Poland | EMED Centrum Uslug Medycznych Ewa Smialek | Rzeszow | Podkarpackie |
| Poland | Centrum Medyczne Ogrodowa Sp. z o.o. | Skierniewice | Lodzkie |
| Poland | Centrum Medyczne "SOPMED" Sp. z o.o. | Sopot | Pomorskie |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka | Starogard Gdanski | Pomorskie |
| Poland | KO-MED Centra Kliniczne Staszow | Staszow | |
| Poland | Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka | Tarnow | Malopolskie |
| Poland | Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga | Tarnow | Malopolskie |
| Poland | Centrum Medyczne AMED | Warszawa | WOJ Mazowieckie |
| Poland | Centrum Medyczne Piaski Filia nr 9 | Warszawa | Mazowieckie |
| Poland | Centrum Medyczne Warszawskiego Uniwersytetu Medycznego Sp. z o.o | Warszawa | |
| Poland | Instytut Kardiologii im | Warszawa | Mazowieckie |
| Poland | Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warszawa | Mazowieckie |
| Poland | Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego Klinika Kardiologii | Warszawa | |
| Poland | Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. | Warszawa | Mazowieckie |
| Poland | Synexus Polska Sp. z o.o. Oddzial w Warszawie | Warszawa | |
| Poland | Wojskowy Instytut Medyczny,Centralny Szpital Kliniczny Ministerstwa Obronty Narodowej | Warszawa | Mazowieckie |
| Poland | Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski | Wloclawek | Kujawsko-pomorskie |
| Poland | NZOZ "Medyk"Sp. z o. o. | Wola | Slaskie |
| Poland | Centrum Opieki Diabetologiczno-Endokrynologicznej i Ginekologiczno-Polozniczej | Wroclaw | |
| Poland | Dobrostan Michal Bogacki | Wroclaw | |
| Poland | Synexus Polska Sp. z o.o. Oddzial we Wroclawiu | Wroclaw | |
| Poland | Zdrowie s.c. Agnieszka i Donald Drozdz | Wroclaw | Dolnoslaskie |
| Poland | KO-MED Centra Kliniczne Zamosc | Zamosc | Lubelskie |
| Poland | Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED | Zarow | Dolnoslaskie |
| Puerto Rico | The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC) | Anasco | |
| Puerto Rico | Cardiometabolic Research Center, Inc. | Ponce | |
| Puerto Rico | Endocrine Lipid Diabetes Research Institute | Ponce | |
| Puerto Rico | Altamira Family Medicine And Research Institute | San Juan | |
| Puerto Rico | Centro de Diabetes para Puerto Rico | San Juan | |
| Puerto Rico | Consultorio Medico Figueroa | San Juan | |
| Puerto Rico | Miguel Sosa-Padilla, MD-Private Practice | San Juan | |
| Puerto Rico | Pradnet Inc. | San Juan | |
| Romania | Dr. Pop Calin Florin - Cabinet Cardiologie | Baia Mare | Maramures |
| Romania | Euromedica Hospital | Baia Mare | |
| Romania | Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital) | Braila | |
| Romania | Centrul Medical de Diagnostic si Tratament Ambulator Neomed | Brasov | |
| Romania | S.C. Polimed Dacia S.R.L. | Brasov | |
| Romania | "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, | Bucharest | |
| Romania | Data Plus Medical Clinic | Bucharest | |
| Romania | Med Plus SRL (Med Plus Ltd.) | Bucharest | |
| Romania | S.C. Centrul Medical "Sanatatea Ta" S.R.L. | Bucharest | |
| Romania | SC Centrul Medical Policlinico Di Monza SRL, Cardiologie | Bucuresti | |
| Romania | SC Clinica Medicala Synexus SRL, Medicina Interna | Bucuresti | |
| Romania | SC Policlinica CCBR SRL | Bucuresti | |
| Romania | Spitalul Clinic Colentina, Departament Cardiologie | Bucuresti | |
| Romania | Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila | Bucuresti | |
| Romania | Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice | Cluj | |
| Romania | County Emergency Hospital Deva | Deva | Hunedoara |
| Romania | Dr. Mistodie Cristina Victoria MD, Office of | Galati | |
| Romania | S.C. Diamed Obesity S.R.L. | Galati | |
| Romania | County Clinical Emergency Hospital Oradea | Oradea | Bihor |
| Romania | Medical Practice SRL | Oradea | Bihor |
| Romania | Pitesti-Arges County Emergency Hospital | Pitesti | Arges |
| Romania | Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice | Ploiesti | Prahova |
| Romania | Dr. Busegeanu Mihaela Private Practice | Ploiesti | Prahova |
| Romania | County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department | Satu Mare | |
| Romania | County Clinical Emergency Hospital Sibiu | Sibiu | |
| Romania | Cardio Med SRL | Targu Mures | |
| Romania | Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice | Targu Mures | Mures |
| Romania | Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat, Nutritie si Boli Metabolice | Timisoara | |
| Romania | Centrul Medical Sf. Stefan | Timisoara | JUD. Timis |
| Romania | Institute of Cardiovascular Diseases Timisoara | Timisoara | Timis |
| Russian Federation | Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6" | Chelyabinsk | |
| Russian Federation | Non-State Institution of Healthcare "Railway Clinical Hospital at station Chelyabinsk of open | Chelyabinsk | |
| Russian Federation | State Budgetary Healthcare Institution "Region Clinical Hospital #3" | Chelyabinsk | |
| Russian Federation | Municipal Autonomous Institution "City Clinical Hospital #14" | Ekaterinburg | |
| Russian Federation | Regional Budgetary Healthcare Institution "Cardiology Dispensary" | Ivanovo | |
| Russian Federation | State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital" | Kaluga | |
| Russian Federation | Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University" | Kazan | |
| Russian Federation | FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2 | Kazan | Tatarstan Republic |
| Russian Federation | SBEI of HPE Kazan State Medical University on the base of SBHI Clinical Hospital No.2 | Kazan | Tatarstan Republic |
| Russian Federation | State Autonomous Healthcare Institution | Kazan | |
| Russian Federation | "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """ | Kemerovo | |
| Russian Federation | Federal state budgetary institution Research institute of complex problems | Kemerovo | |
| Russian Federation | FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across Kemerovo region | Kemerovo | |
| Russian Federation | Municipal Budgetary Institution of Healthcare | Kemerovo | |
| Russian Federation | Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1" | Kirov | |
| Russian Federation | State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1 | Krasnodar | Krasnodar Region |
| Russian Federation | Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital" | Kursk | |
| Russian Federation | State Budgetary Healthcare Institution Of Moscow Region "Lubertsy Regional Hospital #2" | Lubertsy | Moscow Region |
| Russian Federation | Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, | Moscow | |
| Russian Federation | Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic" | Moscow | |
| Russian Federation | Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of Ministry | Moscow | |
| Russian Federation | Federal State Budgetary Institution "State Research Center for Preventive Medicine" of the Ministry | Moscow | |
| Russian Federation | Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin" | Moscow | |
| Russian Federation | Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD" | Moscow | |
| Russian Federation | Russian Cardiology Research And Production Complex of Ministry of Health of Russian Federation | Moscow | |
| Russian Federation | SBEI of HPE I. M. Sechenov First Moscow State Medical University, UKB #2 | Moscow | |
| Russian Federation | SBHI of Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" | Moscow | |
| Russian Federation | SBIH "City Clinical Hospital #81 Departments of Healthcare of Moscow" | Moscow | |
| Russian Federation | State Healthcare Institution "City Clinical Hospital #51 of Healthcare Department of Moscow City" | Moscow | |
| Russian Federation | State Regional Budgetary Healthcare Institution | Murmansk | |
| Russian Federation | State Budgetary Healthcare Institution of Nizhegorodskaya Region | Nizhniy Novgorod | |
| Russian Federation | "Reafan" LLC | Novosibirsk | |
| Russian Federation | "SBHI of Novosibirsk ""City Clinical Hospital of Emergency Medical Care # 2""" | Novosibirsk | |
| Russian Federation | Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine" of | Novosibirsk | |
| Russian Federation | Municipal Budgetary Institution of Healthcare of Novosibirsk | Novosibirsk | |
| Russian Federation | SBRIHPE "Novosibirsk State Medical University" of MHSD of RF | Novosibirsk | |
| Russian Federation | State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency | Novosibirsk | |
| Russian Federation | State Budgetary Institution of Healthcare"Penzenskaya Regional clinical hospital n.a N.N Burdenko" | Penza | |
| Russian Federation | SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko" | Pushkin | |
| Russian Federation | Federal State Budgetary Educational Institution of Higher Education | Rostov-on-Don | |
| Russian Federation | State Budgetary Educational Institution Of Higher Professional Education | Rostov-on-Don | |
| Russian Federation | State Budgetary Educational Institution of Higher Professional Education | Rostov-on-Don | |
| Russian Federation | State Budgetary Institution "Ryazan Regional Clinical Hospital" | Ryazan | Ryazan Region |
| Russian Federation | Federal State Budgetary Institution | Saint Petersburg | |
| Russian Federation | "Limited Liability Company ""Institute of Medical Research""" | Saint-Petersburg | |
| Russian Federation | City Hospital # 38 n.a. Semashko | Saint-Petersburg | |
| Russian Federation | Federal state budget institution of healthcare Saint-Petersburg clinical hospital of Russian Academy | Saint-Petersburg | |
| Russian Federation | Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic" | Saint-Petersburg | |
| Russian Federation | Limited Liability Company "Institute of Medical research" | Saint-Petersburg | |
| Russian Federation | Limited Liability Company "Reavita" | Saint-Petersburg | |
| Russian Federation | Limited Liability Company International Medical Centre SOGAZ | Saint-Petersburg | |
| Russian Federation | LLC "Institution of medical studies" | Saint-Petersburg | |
| Russian Federation | Saint Petersburg State Budgetary Institution of Healthcare Municipal hospital | Saint-Petersburg | Sestroretsk |
| Russian Federation | Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15" | Saint-Petersburg | |
| Russian Federation | Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23" | Saint-Petersburg | |
| Russian Federation | SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MOH of the RF | Saint-Petersburg | |
| Russian Federation | State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary" | Samara | |
| Russian Federation | MHI "City Clinical Hospital #12" of the Healthcare Committee | Saratov | |
| Russian Federation | State Institution of Healthcare "Regional Clinical Hospital" | Saratov | |
| Russian Federation | State Budget Educational Institution of Higher Professional Education | Smolensk | |
| Russian Federation | Federal State Budgetary Educational Institution of Higher Education | St. Petersburg | |
| Russian Federation | GBOU VPO Siberian State Medical University Ministry of Healthcare of the Russian Federation | Tomsk | |
| Russian Federation | State Budgetary Educational Institution of Highest Professional Education "Siberian State Medical | Tomsk | |
| Russian Federation | Tyumen Cardiology Research Center-branch of the Tomsk NRMC | Tomsk | |
| Russian Federation | Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences | Troitsk | Moscow Region |
| Russian Federation | Affiliate of the Federal State Budgetary Institution Scientific Research Institute of Cardiology | Tyumen | |
| Russian Federation | State Autonomous Institution of Healthcare of the Tyumen region Tyumen Institute of Therapy | Tyumen | |
| Russian Federation | FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation | Yaroslavl | |
| Russian Federation | State Autonomous Healthcare Institution of Yaroslavl region | Yaroslavl | |
| Russian Federation | State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10" | Yaroslavl | |
| Russian Federation | State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8" | Yaroslavl | |
| Slovakia | Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica | Banska Bystrica | |
| Slovakia | Stredoslovensky Ustav Srdcovych A Cievnych Chorob A.S. | Banska Bystrica | |
| Slovakia | Alian s.r.o., kardiologicka ambulancia | Bardejov | |
| Slovakia | KARDIO-SANUS spol., s.r.o. | Bratislava | |
| Slovakia | Kardiovaskularne centrum s.r.o. | Bratislava | |
| Slovakia | METABOL KLINIK s. r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy | Bratislava | |
| Slovakia | Metabolicke centrum MUDr. Katariny Raslovej, s.r.o. | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | |
| Slovakia | Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB) | Bratislava | Bratislavsky |
| Slovakia | UN Bratislava Nemocnica Sv. Cyrila a Metoda, kardiologicka ambulancia 1 | Bratislava | |
| Slovakia | UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava | Bratislava | |
| Slovakia | Univerzitna Nemocnica Bratislava | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.intema klinika | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika | Bratislava | |
| Slovakia | VERIA, s.r.o. -Kardiologicka ambulancia | Bratislava | |
| Slovakia | Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia | Dolny Kubin | |
| Slovakia | JM-Interna s.r.o., interna ambulancia | Dolny Kubin | |
| Slovakia | AGTO., spol. s r. o. | Kosice | |
| Slovakia | CARDIO D&R s.r.o. , Kardiologicka ambulancia | Kosice | |
| Slovakia | Cardio D&R spol.s.r.o., Kardiologicka ambulancia | Kosice | |
| Slovakia | Medicentrum Heart, Spol. S.R.O | Kralovsky Chlmec | |
| Slovakia | CELL-B s.r.o. interna ambulancia | Levice | |
| Slovakia | Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas | Liptovsky Mikulas | |
| Slovakia | KARDIO 1 s.r.o. | Lucenec | |
| Slovakia | Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin | Martin | |
| Slovakia | MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva | Moldava nad Bodvou | |
| Slovakia | MUDr. Kanderkova s.r.o., Diabetologicka ambulancia | Namestovo | |
| Slovakia | Kardiocentrum Nitra s.r.o., kardiologicka ambulancia | Nitra | |
| Slovakia | Fakultna Nemocnica s poliklinikou Nove Zamky | Nove Zamky | |
| Slovakia | Mediab s.r.o. Diabetologicka ambulancia | Pezinok | |
| Slovakia | BENIMED s.r.o. | Piestany | |
| Slovakia | Medispol S.R.O. | Presov | |
| Slovakia | Kardioamb s.r.o. | Rimavska Sobota | |
| Slovakia | Medilex s.r.o. Interna ambulancia | Rimavska Sobota | |
| Slovakia | DIAMEL, s.r.o., Diabetologicka ambulancia | Trencin | |
| Slovakia | BV Medical, s.r.o. Diabetologicka ambulancia, | Trnava | |
| Slovakia | Kardiologicka ambulancia | Trnava | |
| Slovakia | Medivasa, s.r.o. | Zilina | |
| South Africa | Global Clinical Trials (Pty) Ltd. | Arcadia, Pretoria | |
| South Africa | IATROS International | Bloemfontein | FREE State |
| South Africa | JOSHA Research | Bloemfontein | FREE State |
| South Africa | Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic | Cape Town | Western CAPE |
| South Africa | Synopsis Research cc | Cape Town | Western CAPE |
| South Africa | Tiervlei Trial Centre | Cape Town | Western CAPE |
| South Africa | Unitas Hospital | Centurion | |
| South Africa | Dr Ganesh c/o Dr NB Maharaj | Durban | Kwazulu-natal |
| South Africa | Glastonbury Medical Research Centre | Durban | Kwazulu-natal |
| South Africa | Suite 502 | Durban | Kwazulu-natal |
| South Africa | Clinresco Centres (Pty) Ltd-Central Professional Suits | Gauteng | |
| South Africa | Midrand Medical Centre | Halfway House | Gauteng |
| South Africa | Centre For Diabetes And Endocrinology | Johannesburg | |
| South Africa | Sunninghill Hospital | Johannesburg | Gauteng |
| South Africa | Sunward Park Hospital | Johannesburg | Gauteng |
| South Africa | I Engelbrecht Research (Pty) Ltd | Lyttelton | Gauteng |
| South Africa | Nash Ranjith Research Centre | Merebank | Durban |
| South Africa | Zinakekele Medical centre | Moloto | Mpumalanga |
| South Africa | Paarl Research Centre | Paarl | |
| South Africa | Charlotte Maxeke Johannesburg Academic Hospital | Parktown | Gauteng |
| South Africa | TREAD Research cc | Parow | |
| South Africa | Medipark Centre for Clinical Research | Pretoria | Gauteng |
| South Africa | Synexus Watermeyer Clinical Research Centre | Pretoria | Gauteng |
| South Africa | Jongaie Research | Pretoria West | Gauteng |
| South Africa | Roodepoort Medicross Clinical Research Centre | Roodepoort | Gauteng |
| South Africa | Helderberg Research Institute | Somerset West | Western CAPE |
| South Africa | Synexus Helderberg Clinical Research Centre | Somerset West | Western CAPE |
| South Africa | Wits Clinical Research | Soweto | Gauteng |
| South Africa | Sunninghill Hospital | Sunninghill | Johannesburg |
| South Africa | Medi-Clinic Heart Hospital | Sunnyside | Gauteng |
| South Africa | Limpopo Clinical Research Initiative | Thabazimbi | Limpopo |
| South Africa | Welkom Clinical trial Centre | Welkom | FREE State |
| South Africa | Drs Joynt Venter & Associates | Witbank (eMalahleni) | Mpumalanga |
| South Africa | Clinical Projects Research SA (Pty) Ltd | Worcester | |
| Spain | Complejo Hospitalario Universitario A Coruna | A Coruna | |
| * Note: There are 1746 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| Pfizer |
United States, Argentina, Australia, Belgium, Brazil, Canada, Chile, China, Colombia, Czechia, Denmark, Finland, France, Germany, Hungary, India, Ireland, Israel, Italy, Korea, Republic of, Mexico, Netherlands, New Zealand, Poland, Puerto Rico, Romania, Russian Federation, Slovakia, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, Turkey, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Event Rate Per 100 Participant-Years For First Occurrence of Major Cardiovascular (CV) Event | Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death (defined as sudden cardiac death, fatal myocardial infarction [MI], death due to heart failure, death due to stroke [fatal ischemic stroke or fatal stroke of undetermined etiology], or death due to other cardiovascular causes) non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infraction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of CV death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of the CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infraction, Non-Fatal Stroke, or Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infarction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, or non-fatal stroke (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of the all-cause death, non-fatal MI, or non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina needing urgent revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infarction, Non-Fatal Stroke and Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of composite endpoint of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For Cardiovascular Death | Event rate per 100 participant-years for cardiovascular death (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of cardiovascular death (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Myocardial Infarction (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any MI (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any MI (fatal or non-fatal) (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For Fatal Myocardial Infarction | Event rate per 100 participant-years for fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Myocardial Infarction | Event rate per 100 participant-years for first occurrence of non-fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal), of Any Etiology | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal), of any etiology (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal), of any etiology (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For Fatal Stroke | Event rate per 100 participant-years for fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of non-fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Congestive Heart Failure (CHF) | Event rate per 100 participant-years for first occurrence of hospitalization for CHF (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for congestive heart failure (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Coronary Revascularization | Event rate per 100 participant-years for first occurrence of coronary revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Coronary Artery Bypass Graft Surgery (CABG) | Event rate per 100 participant-years for first occurrence of CABG (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Percutaneous Coronary Intervention (PCI) | Event rate per 100 participant-years for first occurrence of PCI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Arterial Revascularizations | Event rate per 100 participant-years for first occurrence of any arterial revascularizations (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years) | |
| Secondary | Event Rate Per 100 Participant-Years For All-Cause Death | Event rate per 100 participant-years for all-cause death (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years) | |
| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Baseline, Week 14 | ||
| Secondary | Nominal Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Baseline, Week 14 | ||
| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Last Post-Baseline Measurement | Baseline, last post-baseline measurement (any time up to Week 140) | ||
| Secondary | Percent Change From Baseline in Lipid Levels at Week 14 | Lipids included non-high density lipoprotein cholesterol (non-HDL-C), total cholesterol, very low density lipoprotein cholesterol (VLDL-C), remnant lipoprotein cholesterol (RLP-C), apolipoprotein B (Apo B), HDL-C and apolipoprotein A-I (Apo A-I). | Baseline, Week 14 | |
| Secondary | Percent Change From Baseline in Log-Transformed Lipoprotein (a) (Lp[a]) and Triglycerides at Week 14 | Baseline, Week 14 | ||
| Secondary | Percent Change From Baseline in Log-Transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14 | Baseline, Week 14 |
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